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Birendra Kumar Singh,비비크,이향복,김준섭,김은기 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.12
Prunus spp. and locally available plants (used as folkloric medicine) were screened to find a novel and natural anti-melanogenic agent. Based on p-protein promoter reporter assay (PPRA) the candidate plants were screened in the quest for p-protein inhibitor. Expression profiling of key proteins revealed the molecular mechanism of the melanin inhibition as well as TEM analysis revealed melanosome structure. The screened plant extract through PPRA showed significant down regulation of p-protein, which led to melanin inhibition. Another key melanosomal protein like tyrosinase and TRP-1 was also found to be down-regulated. However, TRP-2 was not affected. TEM analysis of treated cells also revealed that the stage IV melanosomes were lowered in number compared to control. The present study shows the plants used in this study possess good anti-melanogenic properties. However, the P. davidiana has the highest anti-melanogenic property among screened plant extracts.
Singh Birendra Kumar,태건식(Gun-Sik Tae),성연문(Yeon-Moon Sung) 적정기술학회 2021 적정기술학회지(Journal of Appropriate Technology) Vol.7 No.2
AIDS 환자는 전 세계에 4,000만 명인 것으로 추산되며, 주로 개발도상국에서 대부분의 환자가 발생하고 있다. AIDS의 원인 바이러스인 HIV는 혈중의 CD4+ T 세포에 감염되어 수개월 내지 10년 간의 잠복기간을 거치면서 CD4+ T 세포를 점점 파괴하여 환자의 면역기능을 저하시킨다. 이렇게 면역력이 약화된 A IDS 환자는 다양한 병증에 의해 사망에 이르게 된다. 현재의 CD4+ T 세포 수를 계측하는 방법은 통상 유세포분석(flow cytometry) 방법에 의해 시행되고 있다. 유세포분석 방법은 정확도가 높다는 장점이 있으나 숙련된 전문 인력이 필요하고 장비가 고가이기때문에 개발 도상국에서는 이용하기 어렵다. 본 연구결과로 마이크로 여과기를 통해 소량인 5 ㎕ 혈액으로부터 백혈구를 포획하고 포획된 세포에서 CD4+ T 세포 및 CD8+ T 세포를 분석하여 AIDS를 검사하는 장비를 개발하였다. 현재의 검사 장비보다 저렴하고 고도의 기술이 필요하지 않으며 휴대가 간편한 획기적인 A IDS 검사 장비임을 시사한다. It is estimated that there are 40 million people with AIDS worldwide, with most cases occurring mainly in developing countries. HIV, the virus that causes AIDS, is infected with CD4+ T cells in the blood and gradually destroys CD4+ T cells for several months to 10 years, thereby lowering the patient s immune function. AIDS patients who have weakened immunity in this way will die from various diseases. The current method for counting the number of CD4+ T cells is usually performed by flow cytometry. The flow cytometry method has the advantage of high accuracy, but it is difficult to use in developing countries because it requires skilled professionals and equipment is expensive. As a result of this study, a device for AIDS screening was developed by capturing leukocytes from a small amount of 5 ㎕ blood through a microfilter and analyzing CD4+ T cells and CD8+ T cells from the captured cells. cheaper and easier to carry and use than current test equipment.
P-Protein: A Novel Target for Skin-whitening Agent
Birendra Kumar Singh,EUN-KI KIM 한국생물공학회 2019 Biotechnology and Bioprocess Engineering Vol.24 No.1
Skin pigmentation is the most visible phenotype character of human beings and is regulated by many factors. Despite recent advances, the whole process of melanogenesis is not well understood. More than 400 genes are involved in human pigmentation and one of them is the pink-eyed dilution gene (p-gene). The p-gene mutation causes oculocutaneous albinism-2 (OCA-2) in humans. OCA type 2 has a highly variable phenotype. The reaction mechanism of the p-gene is still a mystery. In this review, we focused on the role of the p-gene in the process of melanogenesis. Melanogenesis occurs in a specialized cellular organelle termed as melanosome in which the skin pigment (melanin) is produced. This review is to provide the function of p-gene, their product (p-protein) and their potentials in developing new generation cosmetics.
Kojic Acid Peptide: A New Compound with Anti-Tyrosinase Potential
( Birendra Kumar Singh ),( Seok Hoon Park ),( Hyang Bok Lee ),( Young Aae Goo ),( Hyoung Shik Kim ),( Seung Hee Cho ),( Jeong Hun Lee ),( Ghe Whan Ahn ),( Jin Pyo Kim ),( Su Myoung Kang ),( Eun Ki Kim 대한피부과학회 2016 Annals of Dermatology Vol.28 No.5
Background: Kojic acid was used for decades in the cosmetic industry as an antimelanogenic agent. However, there are two major drawbacks of Kojic acid, one is cytotoxicity and second are instability on storage. These limitations led the scientist to synthesize the active Kojic acid peptides. Objective: In the present study, we synthesize and investigate the effect of five Kojic acid peptides to overcome the limitation of Kojic acid. Methods: The peptide was analyzed and purified by high-performance liquid chromatography and matrix-assisted laser desorption ionization time of flight mass spectroscopy. Further, the tyrosinase activities of the Kojic acid and Kojic acid peptides were compared. The toxicity was measured and the melanin content is recorded in B16F10 mouse melanoma cells. Results: Maximum tyrosinase activity was measured by Kojic acid peptides. Therefore, Kojic acid peptides were subjected to melanin assay and cytotoxicity assay and finally the stability of the Kojic acid peptide was measured. Conclusion: It was observed that this newly synthesized Kojic acid peptide is stable and potent to inhibit the tyrosinase activity and melanin content of B16F10 mouse melanoma cells without exhibiting cell toxicity. Together, these preliminary results suggest that a further exploration is being needed to establish Kojic acid peptide as antimelanogenic agent. (Ann Dermatol 28(5) 555∼561, 2016)
Recent advancements in bioremediation of dye: Current status and challenges
Vikrant, Kumar,Giri, Balendu Shekhar,Raza, Nadeem,Roy, Kangkan,Kim, Ki-Hyun,Rai, Birendra Nath,Singh, Ram Sharan Elsevier 2018 Bioresource technology Vol.253 No.-
<P><B>Abstract</B></P> <P>The rampant industrialization and unchecked growth of modern textile production facilities coupled with the lack of proper treatment facilities have proliferated the discharge of effluents enriched with toxic, baleful, and carcinogenic pollutants including dyes, heavy metals, volatile organic compounds, odorants, and other hazardous materials. Therefore, the development of cost-effective and efficient control measures against such pollution is imperative to safeguard ecosystems and natural resources. In this regard, recent advances in biotechnology and microbiology have propelled bioremediation as a prospective alternative to traditional treatment methods. This review was organized to address bioremediation as a practical option for the treatment of dyes by evaluating its performance and typical attributes. It further highlights the current hurdles and future prospects for the abatement of dyes <I>via</I> biotechnology-based remediation techniques.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Presence of dyes is linked with multitude of problems causing ecological imbalances. </LI> <LI> The effective treatment of dyes is a vital task in environmental pollution control. </LI> <LI> For this, cost-effectiveness, environmental benignity, and ease of operation is important. </LI> <LI> MFCs along with the generation of electricity can be the best alternatives for their abatement. </LI> </UL> </P>
Progress in bioremediation of pesticide residues in the environment
Balendu Shekher Giri,Sachin Geed,Kumar Vikrant,이상수,김기현,Suresh Kumar Kailasa,Meththika Vithanage,Preeti Chaturvedi,Birendra Nath Rai,Ram Sharan Singh 대한환경공학회 2021 Environmental Engineering Research Vol.26 No.6
The increasing use of various pesticides (e.g., organophosphate, organochlorine, carbamates, and pyrethroid) has helped to improve agricultural productivity by minimizing the potential crop losses associated with insect attacks. Owing to their highly recalcitrant nature, most pesticides and their residues often accumulate in the environment to exert deleterious effects on human health and various ecosystems. Among a variety of remediation options, biological approaches have attracted a widespread attention for the treatment of pesticide in soil/water systems due to their environmentally benign nature. In this regard, this review article was organized to highlight the recent advancements in the application of various bioremediation approaches for the degradation/removal of pesticides from soil/water matrixes along with the catabolic capacity of microorganisms. Our discussions were expanded further to emphasize identification of specific bacterial communities/strains, such as Bacillus sp. and Pseudomonas sp. This review is expected to provide an overview of the modern biotechnological methodologies along with the associated merits and hurdles for the effective abatement of pesticides.