Expression and Prognostic Implications of FOXO3a and Ki67 in Lung Adenocarcinomas

Liu, Hong-Bin,Gao, Xiang-Xiang,Zhang, Qing,Liu, Jian,Cui, Yuan,Zhu, Yan,Liu, Yi-Fei Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4

To investigate the significance of FOXO3a and Ki67 in human lung adenocarcinomas. Envision immunohistochemical staining and Western blotting were used to examine the protein expression of FOXO3a in 127 cases of human lung adenocarcinoma specimens. The positive rate in lung adenocarcinoma (55.9%) was lower than that in normal tissues (80%). We found that the expression of FOXO3a was closely related with the degree of differentiation, TNM staging, lymph node metastasis and survival. In addition, significant differences in the different pathological types of lung adenocarcinoma cases (P<0.01). The FOXO3a positive rate of the acini as the main type (APA) (86.7%) and the lepidic as the main type (LPA) (82.4%) was higher than the solid as the main type (SPA) (50.0%), the papilla as the main type (PPA) (42.9%) and the micropapilla as the main type (MPA) (9.4%). Moreover, the expression of FOXO3a was negatively related with Ki67 expression. Our results suggested that the expression of FOXO3a is closely correlated with the aggressiveness of lung adenocarcinoma. It was indicated that disregulation of FOXO3a might play key roles in the occurrence and development of lung a denocarcinoma and joint detection of the two markers might play an important role in diagnosing tumors.

On the forced vibration of high-order functionally graded nanotubes under the rotation via intelligent modeling

Liu, Yang,Wang, Xiaofeng,Liu Li,Wu, Bin,Yang, Qin Techno-Press 2022 Advances in nano research Vol.13 No.1

The present research investigates the dynamic behavior of a rotating functionally graded (FG) nonlocal cylindrical beam. The cylindrical beam is mathematically modeled via third-order beam theory linked with nonlocal strain gradient theory. The tube structure is made of functionally graded materials composed of Aluminum oxide coated on the Nickel, which the mechanical properties vary in the tube radius direction according to the power law. The bending harmonic force is applied in the tube length middle. The nonlocal spinning equations of the tube are derived via the energy method of the Hamilton principle, and they are solved via a robust numerical procedure for different boundary conditions. The main application of the rotating nanostructures is for the production of small-scale motors and devices and the drug-delivery application, the presented results can help the researcher have a better view regarding the different conditions.

Stabilization of Li Metal Anode in DMSO-Based Electrolytes via Optimization of Salt-Solvent Coordination for Li-O₂ Batteries

Liu, Bin,Xu, Wu,Yan, Pengfei,Kim, Sun Tai,Engelhard, Mark H.,Sun, Xiuliang,Mei, Donghai,Cho, Jaephil,Wang, Chong-Min,Zhang, Ji-Guang Wiley (John WileySons) 2017 ADVANCED ENERGY MATERIALS Vol.7 No.14

haracterization of a Recombinant Thermostable Xylanase from Hot Spring Thermophilic Geobacillus sp. TC-W7

( Liu Bin ),( Ning Ning Zhang ),( Chao Zhao ),( Bai Xue Lin ),( Lian Hui Xie ),( Yi Fan Huang ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.10

A xylanase-producing thermophilic strain, Geobacillus sp. TC-W7, was isolated from a hot spring in Yongtai (Fuzhou, China). Subsequently, the xylanase gene that encoded 407 amino acids was cloned and expressed. The recombinant xylanase was purified by GST affinity chromatography and exhibited maximum activity at 75℃ and a pH of 8.2. The enzyme was active up to 95℃ and showed activity over a wide pH range of 5.2 to 10.2. Additionally, the recombinant xylanase showed high thermostability and pH stability. More than 85% of the enzyme`s activity was retained after incubation at 70℃ for 90 min at a pH of 8.2. The activity of the recombinant xylanase was enhanced by treatment with 10 mM enzyme inhibitors (DDT, Tween-20, 2-Me, or TritonX-100) and was inhibited by EDTA or PMSF. Its functionality was stable in the presence of Li+, Na+, and K+, but inhibited by Hg2+, Ni2+, Co2+, Cu2+, Zn2+, Pb2+, Fe3+, and Al3+. The functionality of the crude xylanase had similar properties to the recombinant xylanase except for when it was treated with Al2+ or Fe2+. The enzyme might be a promising candidate for various industrial applications such as the biofuel, food, and paper and pulp industries.

REDUCING SUBSPACES OF A CLASS OF MULTIPLICATION OPERATORS

Liu, Bin,Shi, Yanyue Korean Mathematical Society 2017 대한수학회보 Vol.54 No.4

Let $M_{z^N}(N{\in}{\mathbb{Z}}^d_+)$ be a bounded multiplication operator on a class of Hilbert spaces with orthogonal basis $\{z^n:n{\in}{\mathbb{Z}}^d_+\}$. In this paper, we prove that each reducing subspace of $M_{z^N}$ is the direct sum of some minimal reducing subspaces. For the case that d = 2, we find all the minimal reducing subspaces of $M_{z^N}$ ($N=(N_1,N_2)$, $N_1{\neq}N_2$) on weighted Bergman space $A^2_{\alpha}({\mathbb{B}}_2)$(${\alpha}$ > -1) and Hardy space $H^2({\mathbb{B}}_2)$, and characterize the structure of ${\mathcal{V}}^{\ast}(z^N)$, the commutant algebra of the von Neumann algebra generated by $M_{z^N}$.

The Cauchy problem for an integrable generalized Camassa-Holm equation with cubic nonlinearity

Bin Liu,Lei Zhang 대한수학회 2018 대한수학회보 Vol.55 No.1

This paper studies the Cauchy problem and blow-up phenomena for a new generalized Camassa-Holm equation with cubic nonlinearity in the nonhomogeneous Besov spaces. First, by means of the Littlewood-Paley decomposition theory, we investigate the local well-posedness of the equation in $B_{p,r}^s$ with $s>\max\{\frac{1}{p},\frac{1}{2},1-\frac{1}{p}\}$, $p,r\in [0,\infty]$. Second, we prove that the equation is locally well-posed in $B_{2,r}^s$ with the critical index $s=\frac{1}{2}$ by virtue of the logarithmic interpolation inequality and the Osgood's Lemma, and it is shown that the data-to-solution mapping is H\"{o}lder continuous. Finally, we derive two kinds of blow-up criteria for the strong solution by using induction and the conservative property of $m$ along the characteristics.

Apoptosis of Colorectal Cancer UTC116 Cells Induced by Cantharidinate

Liu, Bin,Gao, Hai-Cheng,Xu, Jing-Wei,Cao, Hong,Fang, Xue-Dong,Gao, Hai-Mei,Qiao, Shi-Xing Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

Effects of Cantharidinate on apoptosis of human colorectal cancer UTC-116 cells were investigated by means of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay, H and E staining, flow cytometry, and Raman Spectra analysis. The results showed Cantharidinate to exert inhibitory action on proliferation of human colorectal cancer UTC-116 cells, inducing apoptosis, arresting cells in G1 phase, with decline of S and G2 phases. In addition, the results of Raman spectrum showed significant changes in the UTC-116 cells chemical structure with stretching after the application of Cantharidinate. Taken together, these results suggest that the treatment of human colorectal cancer with Cantharidinate may be associated with multiple molecular mechanisms for apoptosis. Furthermore, similar to fluorouracil, Cantharidinate should be considered as novel assistant drug for controlling the growth of human colorectal cancer UTC-116 cells.

Fabrication of carbon nanotube-loaded TiO2@AgI and its excellent performance in visible-light photocatalysis

Liu Yang,Yang An,Bin Dai,Xuhong Guo,Zhiyong Liu,Banghua Peng 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.2

Novel, visible light driven CNTs-TiO2@AgI hybrid materials were synthesized by a simple solvothermaldissolution- precipitation method, during which the acid vapor treated carbon nanotubes (CNTs) as template, AgI as sensitizer and TiO2 as the bridge unified them to form a ternary composite. The morphology and chemical components of as-prepared samples were characterized by high-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). XRD and XPS characterizations indicated that anatase TiO2 and crystal AgI co-existed in the composite. HRTEM demonstrated CNTs were decorated with well-dispersed AgI and TiO2 nanoparticles (NPs), and TiO2 had an intimate connection with both AgI and CNTs. Diffusive reflectance UV-vis spectroscopy of CNTs-TiO2@AgI nanocomposite was extended to the whole UV-visible region due to adding of CNTs and AgI NPs. Degradation of Rhodamine B (RhB) polluted water using CNTs-TiO2@AgI NPs was carried out under visible light irradiation, and it showed higher degradation efficiency than CNTs-TiO2, TiO2@AgI, and CNTs@AgI NPs. The primary reason for the enhanced photocatalytic property was attributed to the synergic effect in CNTs-TiO2@AgI, which included the good adsorption ability and electrical conductivity of CNTs as well as the intimate connection and hetero-junctions among AgI, TiO2, and CNTs. Meanwhile, the as-prepared hybrid materials can be easily separated and reclaimed from the liquid phase, and the recycling tests indicated CNTs-TiO2@AgI had renewable performance.

Time Trends of Esophageal Cancer Mortality in Linzhou City During the Period 1988-2010 and a Bayesian Approach Projection for 2020

Liu, Shu-Zheng,Zhang, Fang,Quan, Pei-Liang,Lu, Jian-Bang,Liu, Zhi-Cai,Sun, Xi-Bin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

In recent decades, decreasing trends in esophageal cancer mortality have been observed across China. We here describe esophageal cancer mortality trends in Linzhou city, a high-incidence region of esophageal cancer in China, during 1988-2010 and make a esophageal cancer mortality projection in the period 2011-2020 using a Bayesian approach. Age standardized mortality rates were estimated by direct standardization to the World population structure in 1985. A Bayesian age-period-cohort (BAPC) analysis was carried out in order to investigate the effect of the age, period and birth cohort on esophageal cancer mortality in Linzhou during 1988-2010 and to estimate future trends for the period 2011-2020. Age-adjusted rates for men and women decreased from 1988 to 2005 and changed little thereafter. Risk increased from 30 years of age until the very elderly. Period effects showed little variation in risk throughout 1988-2010. In contrast, a cohort effect showed risk decreased greatly in later cohorts. Forecasting, based on BAPC modeling, resulted in a increasing burden of mortality and a decreasing age standardized mortality rate of esophageal cancer in Linzhou city. The decrease of esophageal cancer mortality risk since the 1930 cohort could be attributable to the improvements of socialeconomic environment and lifestyle. The standardized mortality rates of esophageal cancer should decrease continually. The effect of aging on the population could explain the increase in esophageal mortality projected for 2020.

Analysis of Geographic and Pairwise Distances among Chinese Cashmere Goat Populations

Liu, Jian-Bin,Wang, Fan,Lang, Xia,Zha, Xi,Sun, Xiao-Ping,Yue, Yao-Jing,Feng, Rui-Lin,Yang, Bo-Hui,Guo, Jian Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.3

This study investigated the geographic and pairwise distances of nine Chinese local Cashmere goat populations through the analysis of 20 microsatellite DNA markers. Fluorescence PCR was used to identify the markers, which were selected based on their significance as identified by the Food and Agriculture Organization of the United Nations (FAO) and the International Society for Animal Genetics (ISAG). In total, 206 alleles were detected; the average allele number was 10.30; the polymorphism information content of loci ranged from 0.5213 to 0.7582; the number of effective alleles ranged from 4.0484 to 4.6178; the observed heterozygosity was from 0.5023 to 0.5602 for the practical sample; the expected heterozygosity ranged from 0.5783 to 0.6464; and Allelic richness ranged from 4.7551 to 8.0693. These results indicated that Chinese Cashmere goat populations exhibited rich genetic diversity. Further, the Wright's F-statistics of subpopulation within total (FST) was 0.1184; the genetic differentiation coefficient (GST) was 0.0940; and the average gene flow (Nm) was 2.0415. All pairwise FST values among the populations were highly significant (p<0.01 or p<0.001), suggesting that the populations studied should all be considered to be separate breeds. Finally, the clustering analysis divided the Chinese Cashmere goat populations into at least four clusters, with the Hexi and Yashan goat populations alone in one cluster. These results have provided useful, practical, and important information for the future of Chinese Cashmere goat breeding.