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      • SCOPUSSCIE

        The influence of foreign vs. North American emissions on surface ozone in the US

        Reidmiller, D. R.,Fiore, A. M.,Jaffe, D. A.,Bergmann, D.,Cuvelier, C.,Dentener, F. J.,Duncan, B. N.,Folberth, G.,Gauss, M.,Gong, S.,Hess, P.,Jonson, J. E.,Keating, T.,Lupu, A.,Marmer, E.,Park, R.,Schu Copernicus GmbH 2009 Atmospheric Chemistry and Physics Vol.9 No.14

        <P>Abstract. As part of the Hemispheric Transport of Air Pollution (HTAP; http:// www.htap.org) project, we analyze results from 15 global and 1 hemispheric chemical transport models and compare these to Clean Air Status and Trends Network (CASTNet) observations in the United States (US) for 2001. Using the policy-relevant maximum daily 8-h average ozone (MDA8 O3) statistic, the multi-model ensemble represents the observations well (mean r2=0.57, ensemble bias = +4.1 ppbv for all US regions and all seasons) despite a wide range in the individual model results. Correlations are strongest in the northeastern US during spring and fall (r2=0.68); and weakest in the midwestern US in summer (r2=0.46). However, large positive mean biases exist during summer for all eastern US regions, ranging from 10-20 ppbv, and a smaller negative bias is present in the western US during spring (~3 ppbv). In nearly all other regions and seasons, the biases of the model ensemble simulations are ≤5 ppbv. Sensitivity simulations in which anthropogenic O3-precursor emissions (NOx + NMVOC + CO + aerosols) were decreased by 20% in four source regions: East Asia (EA), South Asia (SA), Europe (EU) and North America (NA) show that the greatest response of MDA8 O3 to the summed foreign emissions reductions occurs during spring in the West (0.9 ppbv reduction due to 20% emissions reductions from EA + SA + EU). East Asia is the largest contributor to MDA8 O3 at all ranges of the O3 distribution for most regions (typically ~0.45 ppbv) followed closely by Europe. The exception is in the northeastern US where emissions reductions in EU had a slightly greater influence than EA emissions, particularly in the middle of the MDA8 O3 distribution (response of ~0.35 ppbv between 35-55 ppbv). EA and EU influences are both far greater (about 4x) than that from SA in all regions and seasons. In all regions and seasons O3-precursor emissions reductions of 20% in the NA source region decrease MDA8 O3 the most - by a factor of 2 to nearly 10 relative to foreign emissions reductions. The O3 response to anthropogenic NA emissions is greatest in the eastern US during summer at the high end of the O3 distribution (5-6 ppbv for 20% reductions). While the impact of foreign emissions on surface O3 in the US is not negligible - and is of increasing concern given the recent growth in Asian emissions - domestic emissions reductions remain a far more effective means of decreasing MDA8 O3 values, particularly those above 75 ppb (the current US standard). </P>

      • SCISCIESCOPUS

        Efficacy of a high quality O<sub>1</sub>/Campos foot-and-mouth disease vaccine upon challenge with a heterologous Korean O Mya98 lineage virus in pigs

        Galdo Novo, S.,Malirat, V.,Maradei, E.D.,Pedemonte, A.R.,Espinoza, A.M.,Smitsaart, E.,Lee, K.N.,Park, J.H.,Bergmann, I.E. Elsevier 2018 Vaccine Vol.36 No.12

        <P><B>Abstract</B></P> <P>In 2010 serotype O foot-and-mouth disease virus of the Mya98 lineage/SEA topotype spread into most East Asian countries. During 2010–2011 it was responsible for major outbreaks in the Republic of Korea where a monovalent O/Manisa vaccine (belonging to the ME-SA topotype) was applied to help control the outbreaks. Subsequently, all susceptible animals were vaccinated every 6 months with a vaccine containing the O/Manisa antigen. Despite vaccination, the disease re-occurred in 2014 and afterwards almost annually. This study focuses on the <I>in vivo</I> efficacy in pigs of a high quality monovalent commercial O<SUB>1</SUB>/Campos vaccine against heterologous challenge with a representative 2015 isolate from the Jincheon Province of the Republic of Korea. Initially, viral characterizations and r<SUB>1</SUB> determinations were performed on six viruses recovered in that region during 2014–2015, centering on their relationship with the well characterized and widely available O<SUB>1</SUB>/Campos vaccine strain. Genetic and antigenic analysis indicated a close similarity among 2014–2015 Korean isolates and with the previous 2010 virus, with distinct differences with the O<SUB>1</SUB>/Campos strain. Virus neutralisation tests using O<SUB>1</SUB>/Campos cattle and pig post vaccination sera and recent Korean outbreak viruses predicted acceptable cross-protection after a single vaccination, as indicated by r<SUB>1</SUB> values, and in pigs, by expectancy of protection. In agreement with the <I>in vitro</I> estimates, <I>in vivo</I> challenge with a selected field isolate indicated that O<SUB>1</SUB>/Campos primo vaccinated pigs were protected, resulting in a PD50 value of nearly 10. The results indicated that good quality oil vaccines containing the O<SUB>1</SUB>/Campos strain can successfully be used against isolates belonging to the O Mya98/SEA topotype.</P>

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