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Bayazid Al Borhan,장영아 한국생물공학회 2021 Biotechnology and Bioprocess Engineering Vol.26 No.5
Andrographolide (AG) is a bioactive natural occurring compound found in a medicinal plant called Andrographis paniculata. AG is highly bioavailable and well-known for anti-cancer, antioxidant, anti-inflammatory, and many other bio-functional activities. Hence, its antiinflammatory effects in keratinocytes have not been studied. The skin inflammations and disruptions on skin permeabilities by cell-mediated inflammatory cytokines lead to chronic inflammatory skin diseases such as allergies, atopic dermatitis, psoriasis, and so on. We have investigated cell viability for evaluating cytotoxicity. Moreover, tumor necrosis factor (TNF)-α, interleukin (IL)-1B, IL-6, and prostaglandin E2 levels have been measured by enzymelinked immunosorbent assay. The effect of AG on nuclear factor kappa B(NF-κB) signaling pathways and inducible nitric oxide synthase and cyclooxygenase-2 expressions have been carried out by western blot analysis. c-Fos presence has been elucidated by confocal microscopy. Furthermore, the skin barrier functions of AG have been investigated in HaCaT cell. AG significantly restored skin barrier functions and reduced inflammation in LPS or TNF-α/IFN-γ stimulated HaCaT cells by preventing NF- κB, c-Fos activation, and modulating filaggrin, involucrin, and loricrin expressions. These results potentially proved that AG could be used as a therapeutic agent against inflammatory skin diseases.
Al Borhan Bayazid,Beong Ou Lim 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The discovery of effective therapeutic agents against neurodegenerative diseases (NDDs) remains challenging. Neurotoxicity, inflammations, and oxidative stress are associating factors of NDDs. NaB is a short-chain fatty acid that reportedly protects cancer, inflammation, obesity and so on. We have investigated the neuroprotective effects of NaB in TNF-α-induced SH-SY5Y cells. The expression of inflammatory mediators, including iNOS, COX-2, MAPK and the apoptotic regulators, including P-53, BAX Protein, and caspase-3 were analyzed by western blot analysis. The apoptotic regulatory gene Bcl-2 and BAX translocation were also investigated. Our results showed that NaB attenuated cell death and inhibited the NO production, iNOS and COX-2 expressions in TNF-α-induced SH-SY5Y cells. NaB notably ameliorated apoptotic regulatory proteins p-53, Caspase cascades, and reversed phosphorylation of MAPKs. NaB ameliorated Glucocorticoid receptor and NLRP3 expressions. NaB also suppressed the BAX activation and modulated Nrf-2, HO-1 and MnSOD expression. Altogether, our results suggest that sodium butyrate has potential therapeutic effects against NDDs.