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Basile Kerleroux,Kevin Janot,Jean François Hak,Johannes Kaesmacher,Wagih Ben Hassen,Joseph Benzakoun,Catherine Oppenheim,Denis Herbreteau,Heloise Ifergan,Nicolas Bricout,Hilde Henon,Takeshi Yoshimoto 대한뇌졸중학회 2021 Journal of stroke Vol.23 No.3
The benefits of mechanical thrombectomy (MT) for patients with acute ischemic stroke (AIS) and a large ischemic core (LIC) at presentation are uncertain. We aimed to obtain up-to-date aggregate estimates of the outcomes following MT in patients with volumetrically assessed LIC. We conducted a Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA)-conformed, PROSPERO-registered, systematic review and meta-analysis of studies that included patients with AIS and a baseline LIC treated with MT, reported ischemic core volume quantitatively, and included patients with a LIC defined as a core volume ≥50 mL. The search was restricted to studies published between January 2015 and June 2020. Random-effects-meta-analysis was used to assess the effect of MT on 90-day unfavorable outcome (i.e., modified Rankin Scale [mRS] 3–6), mortality, and symptomatic intracranial hemorrhage (sICH) occurrence. Sensitivity analyses were performed for imaging-modality (computed tomography-perfusion or magnetic resonance-diffusion weighted imaging) and LIC-definition (≥50 or ≥70 mL). We analyzed 10 studies (954 patients), including six (682 patients) with a control group, allowing to compare 332 patients with MT to 350 who received best-medical-management alone. Overall, after MT the rate of patients with mRS 3–6 at 90 days was 74% (99% confidence interval [CI], 67 to 84; Z-value=7.04; I2=92.3%) and the rate of 90- day mortality was 36% (99% CI, 33 to 40; Z-value=–7.07; I2=74.5). Receiving MT was associated with a significant decrease in mRS 3–6 odds ratio (OR) 0.19 (99% CI, 0.11 to 0.33; P<0.01; Z-value=–5.92; I2=62.56) and in mortality OR 0.60 (99% CI, 0.34 to 1.06; P=0.02; Z-value=–2.30; I2=58.72). Treatment group did not influence the proportion of patients experiencing sICH, OR 0.96 (99% CI, 0.2 to 1.49; P=0.54; Z-value=–0.63; I2=64.74). Neither imaging modality for core assessment, nor LIC definition influenced the aggregated outcomes. Using aggregate estimates, MT appeared to decrease the risk of unfavorable functional outcome in patients with a LIC assessed volumetrically at baseline.
Vegetative response to Verticillium dahliae of italian varieties of olive (Olea europaea L.)
Basile Boris,Sigillo Loredana,Mataffo Alessandro,Corrado Giandomenico 한국원예학회 2023 Horticulture, Environment, and Biotechnology Vol.64 No.6
Verticillium dahliae, the causal agent of vascular wilt, is a cosmopolitan pathogen of olive (Olea europaea L.). Italy is a traditional oil-producing country and its olive growing system is characterized by hundreds of regional varieties. They are widely employed for yielding oils protected by geographical indication systems of the European Union. The aim of this study was to evaluate the influence of V. dahliae on the vegetative growth of young, own-rooted olive plants under natural environmental conditions. Specifically, we analyzed differences in stem elongation, number of leaves and stem diameters in eight local varieties of the Campania region of Italy, plus a reference national cultivar, following artificially infection with a non-defoliating pathotype. Multivariate analysis indicated that a distinction in vulnerability among cultivar can be made considering the inhibitory effect of the fungus on stem extension growth, while the other parameters are less influential. Our work also illustrated the variability in some vegetative parameters among the Campanian germplasm and its influence on the inhibitory effect of the pathogen. Further studies will have to analyze the mechanisms connecting the morpho-physiological alterations with the pathogen invasion of the host tissue.
Perfusion Imaging to Select Patients with Large Ischemic Core for Mechanical Thrombectomy
Basile Kerleroux,Kevin Janot,Cyril Dargazanli,Dimitri Daly-Eraya,Wagih Ben-Hassen,François Zhu,Benjamin Gory,Jean François Hak,Charline Perot,Lili Detraz,Romain Bourcier,Aymeric Rouchaud,Géraud Forest 대한뇌졸중학회 2020 Journal of stroke Vol.22 No.2
Background and Purpose Patients with acute ischemic stroke, proximal vessel occlusion and a large ischemic core at presentation are commonly not considered for mechanical thrombectomy (MT). We tested the hypothesis that in patients with baseline large infarct cores, identification of remaining penumbral tissue using perfusion imaging would translate to better outcomes after MT. Methods This was a multicenter, retrospective, core lab adjudicated, cohort study of adult patients with proximal vessel occlusion, a large ischemic core volume (diffusion weighted imaging volume ≥70 mL), with pre-treatment magnetic resonance imaging perfusion, treated with MT (2015 to 2018) or medical care alone (controls; before 2015). Primary outcome measure was 3-month favorable outcome (defined as a modified Rankin Scale of 0–3). Core perfusion mismatch ratio (CPMR) was defined as the volume of critically hypo-perfused tissue (Tmax >6 seconds) divided by the core volume. Multivariable logistic regression models were used to determine factors that were independently associated with clinical outcomes. Outputs are displayed as adjusted odds ratio (aOR) and 95% confidence interval (CI). Results A total of 172 patients were included (MT n=130; Control n=42; mean age 69.0±15.4 years; 36% females). Mean core-volume and CPMR were 102.3±36.7 and 1.8±0.7 mL, respectively. As hypothesized, receiving MT was associated with increased probability of favorable outcome and functional independence, as CPMR increased, a difference becoming statistically significant above a mismatch-ratio of 1.72. Similarly, receiving MT was also associated with favorable outcome in the subgroup of 74 patients with CPMR >1.7 (aOR, 8.12;95% CI, 1.24 to 53.11; P=0.028). Overall (prior to stratification by CPMR) 73 (42.4%) patients had a favorable outcome at 3 months, with no difference amongst groups. Conclusions In patients currently deemed ineligible for MT due to large infarct ischemic cores at baseline, CPMR identifies a subgroup strongly benefiting from MT. Prospective studies are warranted.
In vitro requirement for periostin in B lymphopoiesis
Siewe, Basile T.,Kalis, Susan L.,Le, Phong T.,Witte, Pamela L.,Choi, Sangdun,Conway, Simon J.,Druschitz, Laurel,Knight, Katherine L. American Society of Hematology 2011 Blood Vol.117 No.14
<B>Abstract</B><P>B lymphopoiesis arrests in rabbits by 4 months of age. To identify molecules that contribute to this arrest, cDNA-representational difference analysis on BM stromal cells from young and adult rabbits showed that expression of Postn that encodes for the extracellular matrix protein periostin dramatically reduced with age. Postn-small interfering RNA OP9 cells lost their capacity to support B-cell development from rabbit or murine BM cells, and reexpression of periostin restored this potential, indicating an in vitro requirement for periostin in B lymphopoiesis. In our system, we determined that periostin deficiency leads to increased cell death and decreased proliferation of B-lineage progenitors. Further, RGD peptide inhibition of periostin/αvβ3 interaction resulted in a marked decrease in B lymphopoiesis in vitro. Microarray analysis of the Postn-small interfering RNA OP9 cells showed decreased expression of key B-lymphopoietic factors, including IL-7 and CXCL12. In vivo, unidentified molecule(s) probably compensate periostin loss because Postn−/− mice had normal numbers of B-cell progenitors in BM. We conclude that the decline in periostin expression in adult rabbit BM does not solely explain the arrest of B lymphopoiesis. However, the interaction of periostin with αvβ3 on lymphoid progenitors probably provides both proliferative and survival signals for cells in the B-cell development pathway.</P>