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Adriana Basile,Barbara Conte,Daniela Rigano,Felice Senatore,Sergio Sorbo 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1
Feijoa sellowiana Berg. fruit, widely used for human consumption, is well appreciated for its good nutritional characteristics and for its pleasant flavor and aroma. In a prior study we showed that the acetonic extract of F. sellowiana fruit exerts a potent antibacterial activity against some Gram-positive and Gram-negative bacterial strains. To confirm and deepen the study on antimicrobial activities of the fruit, in this article we analyze the same extract for its effectiveness against different kind of bacteria both as American Type Culture Collection standard strains and clinically isolates, the Gram-negative Helicobacter pylori, and three fungal strains (one human pathogen and two phytopathogens). Our aim was also to isolate and define the active component(s) involved in the antibacterial, antifungal, and anti-H. pylori activity of the extract through activity-guided fractionation procedures. This allowed us to identify flavone as the active compound of F. sellowiana fruit. Flavone showed a high antibacterial activity against the nine standard bacterial strains tested and the matched clinically isolated bacterial strains and was significantly more active against H. pylori than metronidazole. Pseudomonas aeruginosa, Proteus mirabilis, and Proteus vulgaris from both standard and clinical sources showed a very high sensitivity to flavone (minimal inhibitory concentration [MIC]=1.95μg/mL for standard strains and 3.9μg/mL for clinical isolates of the three bacteria), showing also good minimal bactericidal concentration values. Among fungi tested, Rhyzoctonia solani was the most sensitive strain to the action of flavone (MIC=62.5μg/mL).
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Lucia Tortorella,Cintoni Marco,Matteo Loverro,Conte Carmine,Nicolò Bizzarri,Costantini Barbara,Santullo Francesco,Nazario Foschi,Valerio Gallotta,Giacomo Avesani 대한부인종양학회 2024 Journal of Gynecologic Oncology Vol.35 No.1
Objective: To evaluate pre-operative predictors of early (<30 days) severe complications (gradeDindo 3+) in patients with gynecological malignancy submitted to pelvic exenteration (PE). Methods: We retrospectively analyzed 129 patients submitted to surger y at FondazionePoliclinico Gemelli between 2010 and 2019. We included patients affected by primar yor recurrent/persistent cer vical, endometrial, or vulvar/vaginal cancers. Post-operativecomplications were graded according to the Dindo classification. Logistic regression wasused to analyze potential predictors of complications. Results: We performed 63 anterior PE, 10 posterior PE, and 56 total PE. The incidence ofearly severe post-operative complications was 27.9% (n=36), and the early mortality rate was2.3% (n=3). More frequent complications were related to the urinar y diversion and intestinalsurger y. In univariable analysis, hemoglobin ≤10 g/dL (odds ratio [OR]=4.2; 95% confidenceinter val [CI]=1.65–10.7; p=0.003), low albumin levels (OR=3.9; 95% CI=1.27–12.11; p=0.025),diabetes (OR=4.15; 95% CI=1.22–14.1; p=0.022), 2+ comorbidities at presentation (OR=5.18;95% CI=1.49–17.93; p=0.012) were predictors of early severe complications. In multivariableanalysis, only low hemoglobin and comorbidities at presentation were independent predictors of complications. Conclusion: Pelvic exenteration is an aggressive surger y characterized by a high rate of post-operative complications. Pre-operative assessment of comorbidities and patient health statusare crucial to better select the right candidate for this type of surgery.
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