Chinese herbal medicine (Rupi Sanjie capsule) for the treatment of breast pain: A systematic review and meta-analysis of randomized clinical trials

Bao-yong Lai,Li-yan Jia,Bo-Wen Yu,Shi-Bing Liang,Ai-Jing Chu,Hui-juan Cao,Jian-ping Liu,Xiao-Hua Pei 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.2

Background: Breast pain is one of the most common breast disorders, affecting 41%–69% women in the clinical populations. Chinese herbal medicine (Rupi Sanjie, RPSJ) capsule has been recommended to be commonly used for breast pain in China. This review aimed to systematically collect latest evidence and critically evaluate the eff ;ectiveness and safety of RPSJ capsule for breast pain. Methods: We searched 6 databases from their inception to June 1, 2020 for randomized clinical trials (RCTs) comparing RPSJ capsule with conventional drug therapies, placebo or no treatment. Primary outcomes were breast pain relief, reduction of breast mass and clinical cure rate. Results: Seventeen RCTs were included in total, involving 2899 participants with breast pain. RPSJ capsule showed a significant effects in shortening duration of the breast pain (MD-6.51 days, 95%CI [-8.57, -4.45], n = 82, 1 trial), shortening the duration of breast mass (MD-5.17 days, 95%CI [-7.56, -2.78], n = 82, 1 trial), improving clinical cure rate (RR 1.55, 95% CI [1.21, 2.00], I² = 64%, n = 1398, 10 trials) and total effective rate (RR 1.08, 95% CI [1.03, 1.14], I² = 71%, n = 2170, 14 trials) compared to Tamoxifen (TAM). The meta-analysis showed that the incidence of total adverse events was higher in TAM group than the RPSJ capsule group (RR 0.30, 95%CI [0.21, 0.42], I² = 49%, n = 2122, 13 trials). Conclusions: RPSJ capsule appears to be a potentially effective in treating breast pain and seems generally safe for clinical application. However, this potential benefit is inconclusive due to generally weak evidence, and the findings should be further confirmed in large and rigorous trials.

Epithelial-Mesenchymal Transition and Migration of Prostate Cancer Stem Cells Is Driven by Cancer-Associated Fibroblasts in an HIF-1alpha/beta-Catenin-Dependent Pathway

Yong Luo,Ling Lan,Yong-Guang Jiang,Jia-Hui Zhao,Ming-Chuan Li,Neng-Bao Wei,Yun-Hua Lin 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.2

Although cancer stem cells (CSCs) play a crucial role in seeding the initiation of tumor progression, they do not always possess the same potent ability as tumor metastasis. Thus, precisely how migrating CSCs occur, still remains unclear. In the present study, we first comparatively analyzed a series of prostate CSCs, which exhibited a dynamically increasing and disseminating ability in nude mice. We observed that the transcriptional activity of HIF-1 and -catenin became gradually elevated in these stem cells and their epithelial-mesenchymal transition (EMT) characteristic altered from an epithelial type to a mesenchymal type. Next, we further used cancer-associated fibroblasts (CAFs), which were cultured from surgically re-sected tissues of prostate cancer (PCa) to stimulate prostate CSCs. Similar results were reconfirmed and showed that the protein levels of both HIF-1 and -catenin were markedly improved. In addition, the EMT phenotype displayed a homogenous mesenchymal type, accompanied with increased aggressive potency in vitro. Most importantly, the aforementioned promoting effect of CAFs on prostate CSCs was completely repressed after “silencing” the activity of -catenin by transfection of stem cells with ShRNA. Taken together, our observations suggest that prostate migrating CSCs, with a mesenchymal phenotype, could be triggered by CAFs in a HIF-1alpha/beta-catenin-depen-dent signaling pathway.

Acupuncture for Treatment of Erectile Dysfunction: A Systematic Review and Meta-Analysis

Bao-yong Lai,Hui-juan Cao,Guo-yan Yang,Li-yan Jia,Suzanne Grant,Yu-tong Fei,Emma Wong,Xin-lin Li,Xiao-ying Yang,Jian-ping Liu 대한남성과학회 2019 The World Journal of Men's Health Vol.37 No.3

ChinaPurpose: To assess the effectiveness and safety of acupuncture for erectile dysfunction (ED).Materials and Methods: We searched six major English and Chinese databases included randomized controlled trials (RCTs) testing acupuncture alone or in combination for ED. Dichotomous data were presented as risk ratio (RR) and continuous data were presented as mean difference (MD) both with 95% confidence interval (CI). The Revman (v.5.3) was used for data analyses. Quality of evidence across studies was assessed by the online GRADEpro tool.Results: We identified 22 RCTs, fourteen of them involving psychogenic ED. Most of the included RCTs had high or unclear risk of bias. There was no difference between electro-acupuncture and sham acupuncture with electrical stimulation on the rate of satisfaction and self-assessment (RR, 1.50; 95% CI, 0.71–3.16; 1 trial). Acupuncture combined with tadalafil appeared to have better effect on increasing cure rate (RR, 1.31; 95% CI, 1.00–1.71; 2 trials), and International Index of Erectile Function-5 scores (MD, 5.38; 95% CI, 4.46–6.29; 2 trials). When acupuncture plus herbal medicine compared with herbal medicine alone, the combination therapy showed significant better improvement in erectile function (RR, 1.68; 95% CI, 1.31–2.15; 7 trials). Only two trials reported facial red and dizziness cases, and needle sticking and pruritus cases in acupuncture group. Conclusions: Low quality evidence shows beneficial effect of acupuncture as adjunctive treatment for people mainly with psychogenic ED. Safety of acupuncture was insufficiently reported. The findings should be confirmed in large, rigorously designed and well-reported trials.

Optimal design of hydraulic support landing platform for a four-rotor dish-shaped UUV using particle swarm optimization

Zhang, Bao-Shou,Song, Bao-Wei,Jiang, Jun,Mao, Zhao-Yong The Society of Naval Architects of Korea 2016 International Journal of Naval Architecture and Oc Vol.8 No.5

Four-rotor dish-shaped unmanned underwater vehicles (FRDS UUVs) are new type underwater vehicles. The main goal of this paper is to develop a quick method to optimize the design of hydraulic support landing platform for the new UUV. In this paper, the geometry configuration and instability type of the platform are defined. Computational investigations are carried out to study the hydrodynamic performance of the landing platform using the Computational Fluid Dynamics (CFD) method. Then, the response surface model of the optimization objective is established. The intelligent particle swarm optimization (PSO) is applied to finding the optimal solution. The result demonstrates that the stability of landing platform is significantly improved with the global objective index increasing from 1.045 to 1.158 (10.86% higher) after the optimization process.

樂浪 木槨墓의 棺槨制度 연구

包永超(Bao, Yong-chao) 중부고고학회 2018 고고학 Vol.17 No.3

서기전 2세기 말기부터 낙랑지역에서 새로운 묘제인 목곽묘가 등장하여 서기전 1세기에 낙랑군 각지에서 대량 보급이 시작되었다. 낙랑군 군현제도의 공고화, 관리 체계의 완성, 변 군과 중원 내지 관계의 강화에 따라 한식 관곽제도가 낙랑군에 도입되었다. 낙랑 목곽묘의 관곽제도는 4단계로 나누어 볼 수 있다. 낙랑 목곽묘 관곽제도의 변천 과정은 제1기 수용기 → 제2기 발전기 → 제3기 僭越기 → 제4기 혼란기로 구분할 수 있다. 낙랑 전실묘가 제4기 혼란기에 등장하였던 점은 이러한 변천이 동북아시아의 정치 상황의 변동과 그에 따르는 한문화의 수입 및 그 요건 등과 큰 관련이 있었던 때문이라 판단된다. 다만 낙랑 목곽묘와 관련 지역인 요서ㆍ요동군과 廣陵國의 관곽제도와 비교해 보면 낙랑지역의 관곽제도는 요서ㆍ요동군과 광릉국의 관곽제도처럼 전국 말기의 관곽제도 전통을 계승하는 현상이 보이지 않는다. 이는 자료의 한정성 때문일 수 있다. 그리고 낙랑 목곽묘 3기부터 관곽제도를 참월했을 뿐 아니라 관곽 중첩수도 중원지역과 차이가 있었다. 중원지역의 관곽 양식에서 곽의 중첩수가 보통 2중을 넘지 않지만, 낙랑 목곽묘의 곽은 4중 곽까지 나타났으며, 이는 중원지역에서는 보이지 않는다. 관의 사용에서도 낙랑지역은 중원지역과 달리 1중 관이 대부분이고 예외적으로 2중 관이 사용되는 것에 비해 중원지역의 높은 등급인 목곽묘는 2중 관을 채용하는 것이 보편적이다. 이러한 형식은 낙랑지역의 특성으로 이해할 수 있다. Wooden-chambered tombs existed in nangnang in the 2nd century BC and later Han system of inner and outer coffins passed into this region. This study mainly discusses the establishment and development process of the system in Nangnang period in the northwestern part of the Korean peninsula. Nangnang wooden-chambered tombs are divided into four phases according to typical artifacts in them. Examine layer patterns of the coffins in each period, and verify whether burial objects that can manifest the difference in identity reflect the difference in ranks. Wooden-chambered tombs of phase I present a layer pattern of one inner coffin and one outer coffin and chiefs of indigenous peoples may be their owners. Wooden-chambered tombs of phase II include a three-layer pattern of one inner coffin and two outer coffins or two inner coffins and one outer coffin, and a two-layer pattern of one inner coffin and one outer coffin. Through investigating the identity of the tomb owner and the funeral objects capable of manifesting differences in identity, we speculate that dependent officials of nangnang and other senior Aboriginal Chinese groups might use a three-layer pattern of one inner coffin and two outer coffins and a county magistrate or an officer in charge of affairs of indigenous peoples as well as dependant officers might use a two-layer pattern of one inner coffin and one outer coffin. The use of layer patterns of coffins is in accordance with hierarchy of Han Empire. Wooden-chambered tombs of phase III have a four-layer pattern of one inner coffin and three outer coffins, a three-layer pattern of one inner coffin and two outer coffins and a two-layer pattern of one inner coffin and one outer coffin. Through investigating the identity of the tomb owner and the funeral objects capable of manifesting differences in identity, we speculate that level-1 senior officers of a county used a four-layer pattern of one inner coffin and three outer coffins. Tomb owners of one inner coffin and two outer coffins and one outer coffin and one outer coffin are unknown. However, through investigating funeral objects capable of manifesting differences in identity, we argue that their owners had less distinguished identities than those of one inner coffin and three outer coffins, and the owners of one inner coffin and two outer coffins were nobler than those of one inner coffin and one outer coffin. The above show that the system of inner and outer coffins was established. However, the system of nangnang had broken away from the criterion of Han Empire and created a system of its own. Wooden-chambered tombs of phase IV present a five-layer pattern of one inner coffin and four outer coffins, a four-layer pattern of one inner coffin and three outer coffins, a three-layer pattern of one inner coffin and two outer coffins, and a two-layer pattern of one inner coffin and one outer coffin. Through investigating the identity of the tomb owner and the funeral objects capable of manifesting differences in identity, we know that the use of coffins had been out of rule to the extent that not only feudatory kings used five-layer patterns of coffins, but just feudatory kings of the Western Han Dynasty used Ticou(题凑). The grade of coffins and the rank of burial objects do not agree.

A Research of Engineering Construction Based on Credit Risk

Lu Shi-bao,Huang Qiang,ZHANG Yong-yong,SUN Dong-yong 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10

Engineering construction companies often default on the contract expird, which makes the enterprise"s own quality and credibility be affected. Therefore, the construction enterprises should be aware that the value of their own credit, financial sector should also be on the borrowers to assess credit risk, so as not to appear in the portfolio risk. This article utilizes the modern credit grading method toevaluate the construction enterprise"s Credit rating. The study found: Change index credit transpose matrix has a great impact. It will affect the credit rating chages. Credit Change this index ranged from zero when the critical state has a different default status, when the credit quality index greater than zero, the rise in the value of its credit; if the credit quality index is less than zero, the credit quality of the index on the lower Level; If zero, credit rating is tomaintain the normal status, and obtained the illustration through the example.

특별강연 및 일반연제 발표 : 항섬유화 제재를 이용한 사구체 경화증 진행방지의 시도

김용진 ( Kim Yong Jin ),박호선 ( Park Ho Seon ),조인호 ( Jo In Ho ),박용훈 ( Park Yong Hun ),이철호 ( Lee Cheol Ho ),현병화 ( Hyeon Byeong Hwa ),( Bao Li Hua ) 대한신장학회 1999 춘계학술대회 초록집 Vol.18 No.2

Analysis of Slot Leakage Reactance of Submersible Motor with Closed Slots during Starting Transient Operation

Bao, Xiaohua,Di, Chong,Fang, Yong The Korean Institute of Electrical Engineers 2016 Journal of Electrical Engineering & Technology Vol.11 No.1

Generally, closed slots are adopted to reduce the water friction loss in both the stator and the rotor of water filling submersible motor due to the special environment of operation. One of the obvious differences between the traditional induction motors and water filling submersible motors is that the submersible motors only need relatively smaller starting torque. This paper aims to analyze the slot leakage reactance of water filling submersible motor during starting transient operation. An improved analytical method which considered the magnetic saturation of the slot bridge and the skin effect of rotor bars is proposed. The slot permeance factor which has a direct impact on the slot leakage reactance is calculated. Then finite element models with different stator slot types are constructed and search coils are introduced to measure the slot flux linkage. Moreover, the starting performances of the models with two typical stator slots are compared and the flux leakage characteristics are obtained. Finally, the results obtained by finite element method are very close to the results obtained by analytical method.

Optimal design of hydraulic support landing platform for a four-rotor dish-shaped UUV using particle swarm optimization

Bao-Shou Zhang,Baowei Song,Jun Jiang,Zhao-Yong Mao 대한조선학회 2016 International Journal of Naval Architecture and Oc Vol.8 No.5

Four-rotor dish-shaped unmanned underwater vehicles (FRDS UUVs) are new type underwater vehicles. The main goal of this paper is to develop a quick method to optimize the design of hydraulic support landing platform for the new UUV. In this paper, the geometry configuration and instability type of the platform are defined. Computational investigations are carried out to study the hydrodynamic performance of the landing platform using the Computational Fluid Dynamics (CFD) method. Then, the response surface model of the optimization objective is established. The intelligent particle swarm optimization (PSO) is applied to finding the optimal solution. The result demonstrates that the stability of landing platform is significantly improved with the global objective index increasing from 1.045 to 1.158 (10.86% higher) after the optimization process.

Autonomous Task Allocation in a Swarm of Foraging Robots: An Approach Based on Response Threshold Sigmoid Model

Bao Pang,Yong Song,Chengjin Zhang,Hongling Wang,Runtao Yang 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.4

This paper proposes a task allocation model to adjust the number of working robots autonomously ina swarm of foraging robots. In swarm foraging, the traffic congestion in foraging area and the physical interferencebetween robots can decrease the swarm performance significantly. We introduce the concept of traffic flowdensity for the first time which can be used to reflect the traffic condition in the foraging area. The amount ofobstacle avoidance denotes the number of times physical interference generated in swarm foraging. The traffic flowdensity and the amount of obstacle avoidance together adjust the value of the threshold. In the proposed responsethreshold sigmoid model (RTSM), the individual robot can determine autonomously whether to forage or not onthe basis of the threshold and the external stimulus and the swarm system can complete the expected foraging task. Simulation experiments are carried out with the aim of evaluating the performance of the proposed method. Severalperformance measures are introduced to analyze the experimental results and compare to adaptive responsethreshold model (ARTM). Experimental results verify that the RTSM improves foraging efficiency and decreasesthe physical interference.