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Polyanizidine and Polycaprolactone Nanofibers for Designing the Conductive Scaffolds
Bakhshali Massoumi,Raana Sarvari,Amir Zareh,Younes Beygi-Khosrowshahi,Samira Agbolaghi 한국섬유공학회 2018 Fibers and polymers Vol.19 No.10
The main objective of this work was chemically bioactivation of the conducting polyanizidine (PANIZ) by incorporating a polyester such as polycaprolactone (PCL). Modified PANIZ nanocomposites were synthesized through ring opening and chemical oxidation polymerizations. A four-point probe was applied to measure the conductivity of newly synthesized star-like block copolymer (S-PCL-PANIZ) nanocomposite, which was about 0.44 S cm-1. Conductive biodegradable nanofibers were prepared by electrospinning with 25 and 75 % (wt/wt) S-PCL-PANIZ to PCL. The contact angle of each prepared nanofiber was 87±3 o, supporting their usefulness for cell culture. The cultured mouse osteoblast MG63 cells demonstrated normal morphology and significantly higher adhesion and spreading on the nanofiber. The bioactivated PANIZ based nanocomposite may be fruitful in tissue engineering to fabricate conducting biodegradable scaffolds with improved cell adhesion properties for various cell cultures.
Bakhshali Massoumi,Mojtaba Abbasian,Balal Khalilzadeh,Rana Jahanban-Esfahlan,Hadi Samadian,Hossein Derakhshankhah,Mehdi Jaymand 한국섬유공학회 2021 Fibers and polymers Vol.22 No.1
Two novel electrically conductive nanofibrous scaffolds based on chitosan-grafted polythiophene (CS-g-PTh),and chitosan-grafted polythiophene/poly(ε-caprolactone) (CS-g-PTh/PCL) have been fabricated through electrospinningtechnique, and their performances in tissue engineering (TE) application were preliminary investigated in terms of biological(biocompatibility, biodegradability, and enhancing the cells adhesion and proliferation) as well as physicochemical (composition,electroactivity, conductivity, hydrophilicity, and morphology) features. The conductivities of the CS-g-PTh and CS-g-PTh/PCL nanofibrous scaffolds were determined as 0.09 and 8×10-3 Scm-1, respectively. The developed CS-g-PTh/PCL scaffoldexhibited slightly higher cells proliferation (8.24±0.49) than those of the CS-g-PTh scaffold (7.1±0.38) in time period of 7days. The biodegradability tests using gravimetric approach revealed that the mass loss of CS-g-PTh and CS-g-PTh/PCLelectrospun nanofibers were about 28.1 and 37.3 wt.%, respectively, at the end of experiments (sixth weeks). It was foundthat the electrospinning of CS-g-PTh with PCL improves the nanofibers uniformity as well as the biological features (e.g.,biocompatibility and cell proliferation) of the resultant scaffold.