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고혈압(高血壓) 뇌졸중(腦卒中) 환자(患者)에 대한 사혈(瀉血)의 강압효과(降壓效果)
문장혁,안호진,정동화,윤형선,장재원,김경선,문익렬,백종엽,이상무,Mon, Jang-hyuk,Ahn, Ho-jin,Jeong, Dong-hwa,Yoon, Hyung-sun,Jang, Jae-won,Kim, Kyung-sun,Moon, Ik-ryoul,Baek, Jong-yeob,Lee, Sang-moo 대한침구의학회 2003 대한침구의학회지 Vol.20 No.2
Objective : The aim of this research was to investigate the depressive effect of depletion of B15(心兪), B23(腎兪), L5(尺澤), B40(委中) in hypertentive stroke patients. Methods : Depletion on B15(心兪), B23(腎兪), L5(尺澤), B40(委中) in hypertentive stroke patient who were admitted in Dong-Seo Oriental Medical Hospital every other day form 4 weeks, without western antihypertensive drug. Results : After treatment in 2nd week, depletion on B15(心兪), B23(腎兪), L5(尺澤), B40(委中) without western antihypertensive drug increased the systolic and diastolic blood pressure. After treatment in 4th week, depletion on B15(心兪), B23(腎兪), L5(尺澤), B40(委中) without western antihypertensive drug decreased the systolic and diastolic blood pressure. After treatment in 4th week, values of RBC and hemoglobine were not significantly changed. Conclusions : Continous depletion on B15(心兪), B23(腎兪), L5(尺澤), B40(委中) in hypertentive stroke patient without western antihypertensive drug implies decreasement of blood pressure, without change of values of RBC and hemoglobine.
Baek, Dong Won,Kang, Byung Woog,Kim, Jong Gwang Chonnam National University Medical School 2018 CMJ Vol.54 No.3
<P>The present study evaluated the survival impact of standard adjuvant chemotherapy and prognostic differences between Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC) and EBV-negative gastric cancer (EBVnGC). A total of 276 patients were enrolled according to the following criteria: 1) pathologically diagnosed with primary gastric adenocarcinoma, 2) test results from EBV-encoded RNA in situ hybridization, 3) stage II/III according to the 7th edition of UICC/AJCC staging system for gastric cancer, and 4) postoperative adjuvant chemotherapy. Fifty-nine (21.4%) and 217 (78.6%) patients exhibited EBVaGC and EBVnGC, respectively, while 129 (46.7%) patients were classified as stage II and 147 (53.3%) as stage III. As for adjuvant chemotherapy, 87 (31.5%) patients received capecitabine and oxaliplatin, while 189 (68.5%) received S-1 monotherapy. With a median follow-up duration of 21.3 (6.4-89.0) months, the estimated 3-year disease-free survival (DFS) and overall survival (OS) rates were 74.8% and 83.0%, respectively. In univariate analysis and multivariate analysis using a Cox proportional hazard model including age, gender, stage, Lauren classification, and the type of chemotherapy, EBV-positivity was not significantly associated with DFS (p-value= 0.630) regardless of the type of chemotherapy. Therefore, no association was found between EBV positivity and the survival outcomes in patients with curatively resected gastric cancer who received standard adjuvant chemotherapy.</P>
Robust capacitive touch sensor using liquid metal droplets with large dynamic range
Won, Dong-Joon,Baek, Seungbum,Huh, Myoung,Kim, Hojin,Lee, Sanghyun,Kim, Joonwon Elsevier 2017 Sensors and actuators. A, Physical Vol.259 No.-
<P><B>Abstract</B></P> <P>In this paper, we introduce an interesting design for a capacitive touch sensing mechanism using liquid metal (LM) droplets to maintain the advantage of the floating electrode (robustness) and simultaneously improve the dynamic range of the device. LM has electric conductivity, thus it can be used as a floating electrode, and it simultaneously has the deformability of liquid, which does not suffer from fatigue. Therefore, the robustness of the device can be improved. The sensor uses changes in capacitance caused by the overlap area between the LM droplet and a pair of flat-bottom electrodes to improve its dynamic range. To verify the performance of the sensor, a total of 36 sensing elements with a spatial resolution of 2mm and arranged in a 6×6 array were successfully fabricated using micromachining techniques. The performance of the fabricated device was analysed by one-cell and multi-touch tests. The device has a large dynamic range (∼40pF). In addition, using the merits of the device, we applied our concept to an end-effector.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We introduce an interesting capacitive touch sensing mechanism using liquid metal to improve robustness and dynamic range of the device. </LI> <LI> Capacitance is measured by using variations of the overlap between liquid metal and two flat-bottom electrodes. </LI> <LI> We confirmed multi-touch capability and that our measurement system can measure numerous cells (6×6) in real time. </LI> <LI> Finally, to verify the superiority, the concept of the device was applied to an end-effector. </LI> </UL> </P>
Baek, Ji Hyun,Kim, Byeong Jo,Han, Gill Sang,Hwang, Sung Won,Kim, Dong Rip,Cho, In Sun,Jung, Hyun Suk American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.2
<P>Coupling dissimilar oxides in heterostruetures allows the engineering of interfacial, optical, charge separation/transport and transfer properties of photoanodes for photo electrochemical (PEC) water splitting. Here, we demonstrate a double-heterojunction concept based on a BiVO4/WO3/SnO2 triple-layer planar heterojunction (TPH) photoanode, which shows simultaneous improvements in the charge transport (similar to 93% at 1.23 V vs RHE) and transmittance at-longer wavelengths (>500 nm). The TPH photoanode was prepared by a facile solution method: a porous SnO2 film was, first deposited on a fluorine-doped tin oxide (FTO)/glass-substrate followed by WO3 deposition, leading to the formation of a double layer of dense WO3 and a WO3/SnO2 mixture at the bottom. Subsequently, a BiVO4 nanoparticle film was deposited by spin coating. Importantly, the WO3/(WO3+SnO2) composite bottom layer forms a disordered heterojunction enabling intimate contact, lower interfacial resistance, and efficient charge transport/transfer. In addition, the top BiVO4/WO3 heterojunction layer improves light absorption and charge separation. The resultant TPH photoanode shows greatly improved internal quantum efficiency (similar to 80%) and PEC water oxidation performance, (similar to 3.1 mA/cm(2) at 1.23 V vs RHE) compared to the previously reported BiVO4/WO3 photoanodes. The PEC performance was , further improved by a reactive-ion etching treatment and CoOx electrocatalyst deposition. Finally, we demonstrated a bias-free and stable solar water-splitting by constructing a tandem PEC device with a perovskite solar cell (STH similar to 3.5%).</P>
Radiobiological Characterization of Proton Beam at the National Cancer Center in Korea
BAEK, Hye-Jung,KIM, Tae-Hyun,SHIN, Dongho,KWAK, Jung-Won,CHOO, Dong-Wan,LEE, Se-Byung,FURUSAWA, Yoshiya,ANDO, Koichi,KIM, Sang-Soo,CHO, Kwan-Ho Journal of Radiation Research Editorial Committee 2008 JOURNAL OF RADIATION RESEARCH Vol.49 No.5
<P>Estimation of the relative biological effectiveness (RBE) of the proton beam at the National Cancer Center Proton Therapy Center in Korea (NCCPTC) is required clinically for the treatment of cancer. The proton beam was fixed at 190 MeV with 6 cm a spread out Bragg peaks (SOBP) for which corresponds to most frequent clinical condition. The RBE was estimated from the survival of human salivary gland (HSG) cells using the traditional colonogenic and MTT assays. The HSG cells were also irradiated in a cell-stack chamber and monitored for survival to identify whether the characteristic depth-dependent survival pattern was observed. The RBE of the NCCPTC was estimated to be 1.024 ± 0.007 and 1.049 ± 0.028 at the middle of SOBP using colonogenic and MTT assays, respectively. Further analysis of the biological response of proton exposure revealed no difference compared to conventional X-ray treatment in western blot, and FACS analysis. The proton beam of the NCCPTC also exhibited the characteristic depth-dependent survival pattern. The estimated RBE value of NCCPTC was slightly smaller than generic RBE value of 1.1 for protons of the majority of centers. Due to the recommendation of a generic RBE of 1.1 for protons, a representative RBE value of 1.1 was assigned for clinical application for proton beams at the NCCPTC.</P>
Dong-Mok Lee,Woo-Yeon Kong,Je-Shin Park,Won Baek Kim,손인진 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.4
Nano-powders of Ni and Al2O3 were synthesized from NiO and Al powders by high energy ball milling. The nanocrystalline Al2O3 - reinfored composite was consolidated by a pulsed current activated sintering(PCAS)) method within 2 minutes from mechanically synthesized powders of Al2O3 and 3Ni. The average hardness and fracture toughness values obtained were 690 kg/mm² and 6.1MPa·m½, respectively.
Baek, Dong-won,Nam, Jae-sung,Koo, Yoon-Duck,Kim, Doh-Hoon,Lee, Ji-young,Jeong, Jae-Cheol,Kwak, Sang-Soo,Chung, Woo-Sik,Lim, Chae-Oh,Bahk, Jeong-Dong,Hong, Jong-Chan,Lee, Sang-Yeol,Maki Kawai-Yamada,Hi Plant molecular biology and biotechnology research 2004 Plant molecular biology and biotechnology research Vol.2004 No.-
An Arabidopsis protoplast system was developed for dissecting plant cell death in individual cells. Bax, a mammalian pro-apoptotic member of the Bcl-2 family, induces apoptotic-like cell death in Arabidopsis. Bax accumulation in Arabidopsis mesophyll protoplasts expressing murine Bax cDNA from a glucocorticoid-inducible promoter results in cytological characteristics of apoptosis, namely DNA fragmentation, increased vacuolation, and loss of plasma membrane integrity. In vivo targeting analysis monitored using jellyfish green fluorescent protein (GFP) reporter indicated full-length Bax was localized to the mitochondria, as it does in animal cells. Deletion of the carboxyl-terminal transmembrane domain of Bax completely abolished targeting to mitochondria. Bax expression was followed by reactive oxygen species (ROS) accumulation. Treatment of protoplasts with the antioxidant N-acetyl-L-cysteine (NAC) during induction of Bax expression strongly suppressed Bax-mediated ROS production and the cell death phenotype. However, some population of the ROS depleted cells still induced cell death, indicating that there is a process that Bax-mediated plant cell death is independent of ROS accumulation. Accordingly suppression of Bax-mediated plant cell death also takes place in two different processes. Over-expression of a key redox-regulator, Arabidopsis nucleoside diphosphate kinase 2 (AtNDPK2) down-regulated ROS accumulation and suppressed Bax-mediated cell death and transient expression of Arabidopsis Bax inhibitor-1 (AtBI-1) substantially suppressed Bax-induced cell death without altering cellular ROS level. Taken together. our results collectively suggest that the Bax-mediated cell death and its suppression in plants is mediated by ROS-dependent and -independent processes.