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Pain Fiber Anesthetic Reduces Brainstem Fos after Tooth Extraction
Badral, B.,Davies, A.J.,Kim, Y.H.,Ahn, J.S.,Hong, S.D.,Chung, G.,Kim, J.S.,Oh, S.B. SAGE Publications 2013 Journal of dental research Vol.92 No.11
<P>We recently demonstrated that pain-sensing neurons in the trigeminal system can be selectively anesthetized by co-application of QX-314 with the TRPV1 receptor agonist, capsaicin (QX cocktail). Here we examined whether this new anesthetic strategy can block the neuronal changes in the brainstem following molar tooth extraction in the rat. Adult male Sprague-Dawley rats received infiltration injection of anesthetic 10 min prior to lower molar tooth extraction. Neuronal activation was determined by immunohistochemistry for the proto-oncogene protein c-Fos in transverse sections of the trigeminal subnucleus caudalis (Sp5C). After tooth extraction, c-Fos-like immunoreactivity (Fos-LI) detected in the dorsomedial region of bilateral Sp5C was highest at 2 hrs (<I>p</I> < .01 <I>vs</I>. naïve ipsilateral) and declined to pre-injury levels by 8 hrs. Pre-administration of the QX cocktail significantly reduced to sham levels Fos-LI examined 2 hrs after tooth extraction; reduced Fos-LI was also observed with the conventional local anesthetic lidocaine. Pulpal anesthesia by infiltration injection was confirmed by inhibition of the jaw-opening reflex in response to electrical tooth pulp stimulation. Our results suggest that the QX cocktail anesthetic is effective in reducing neuronal activation following tooth extraction. Thus, a selective pain fiber ‘nociceptive anesthetic’ strategy may provide an effective local anesthetic option for dental patients in the clinic.</P>
백일현(I. H. Baek),바드랄철몽(T. M. Badral),조인성(I. S. Cho),정재연(J. Y. Jung),오석형(S. H. Oh) 유공압건설기계학회 2009 유공압건설기계학회 학술대회논문집 Vol.2009 No.11
On the power steering system of the automobile, the balanced type fixed displacement vane pump is principally applied to the main pump. In this pump, it is important to the pressure compensated type flow control valve. For the flow control valve controls the flow rate which needed to operate the actuatro, it has the pressure compensator that kept the pressure difference between the foward and rear position of the orifice constantly. When the inlet flow is proportionally increased by rotational velocity, the controlled flow is passed to the orifice but the overflow is bypassed to the inlet prot of cartridge by return spool. Therefore, in this paper, th theoretical simulation to parameters affected to the flow control had performed. The results show that the impact factors such as the orifice area, the spring stiffness, and the initial force exert a influence on the flow control valve characteristic of the balanced type fixed displacement vane pump.
Choi, Nak Hwan(최낙환),NARAN BADRAL(버드랄나랑),ZHUOQI TENG(등탁기) 한국산업경제학회 2020 산업경제연구 Vol.33 No.1
이 연구는 사회적 아이덴티티 독특성을 느낀 소비자가 친밀집단과의 동석욕구에 의해 내집단의 영역을 확장하여 확장된 내집단이 선호하는 제품에 대한 긍정적인 태도를 형성하는 과정을 연구하였다. 한국에 유학을 온 151명의 중국학생을 대상으로 설문조사를 하여 자료를 수집하고 Amos22.0의 구조방정식모형으로 분석하여 결과를 도출하였다. 첫째, 사회적 아이덴티티의 독특성은 친밀집단과 동석하려는 욕구를 증가시켰다. 둘째, 친밀집단과 동석욕구는 내집단의 영역을 확장시켰다. 셋째, 내집단 영역의 확장은 확장된 내집단이 선호하는 제품에 대한 태도에 긍정적인 영향을 주었다. 종합적으로, 확장된 내집단이 선호하는 제품에 대한 태도에 사회적 아이덴티티의 영향과정에 친밀집단과 동석욕구와 내집단의 영역을 확장이 매개역할을 하는 것으로 분석되었다. 따라서 마케터는, 사회적 아이덴티티의 독특성을 느끼는 소비자에게, 그 소비자와 유사한 특성을 갖고 있는 집단을 파악하고 그 집단이 선호하는 자신의 제품을 식별하여, 접근해야 한다. Current study aimed at investigating whether consumers who feel social identity distinctiveness will feel the desire of being together with intimacy group and expand their in-group boundary to change their attitude towards the products preferred by their in-group expanded. 151 Chinese students in South Korea participated in the questionnaire survey, and structural equation model of AMOS 22.0 was used to test hypotheses, which showed the following results. First, the social identity distinctiveness increased the desire to be together with intimacy group. Second, the desire expanded their social in-group boundary. Third, the expansion of in-group boundary induced the positive attitude towards the product preferred by the in-group expanded. Managerially, marketers should try to make their efforts to find the group who have characteristics similar to the consumers who feel the social identity distinctiveness, and should approach them by their products preferred by the members of the in-group expanded.