Comparison of 90‐day case‐fatality after ischemic stroke between two different stroke outcome registries using propensity score matching analysis

Yu, K‐,H.,Hong, K‐,S.,Lee, B‐,C.,Oh, M‐,S.,Cho, Y‐,J.,Koo, J‐,S.,Park, J‐,M.,Bae, H‐,J.,Han, M‐,K.,Ju, Y‐,S.,Kang, D‐,W.,Appelros, P. Blackwell Publishing Ltd 2011 Acta neurologica Scandinavica Vol.123 No.5

<P>Yu K‐H, Hong K‐S, Lee B‐C, Oh M‐S, Cho Y‐J, Koo J‐S, Park J‐M, Bae H‐J, Han M‐K, Ju Y‐S, Kang D‐W, Appelros P, Norrving B, Terent A. Comparison of 90‐day case‐fatality after ischemic stroke between two different stroke outcome registries using propensity score matching analysis. 
Acta Neurol Scand: 2011: 123: 325–331. 
© 2010 John Wiley & Sons A/S.</P><P><B>Background – </B> It has not been clarified whether the disparity in ischemic stroke outcome between populations is caused by ethnic and geographic differences or by variations in case mix. Propensity score matching (PSM) analysis can overcome some analytical problems but is rarely used in stroke outcome research. This study was to compare the ischemic stroke case‐fatality between two PSM cohorts of Sweden and Korea.</P><P><B>Methods – </B> Prognostic variables related to baseline characteristics and stroke care were included in our PSM model. Then, we selected 7675 Swedish and 1220 Korean patients with ischemic stroke from each stroke registers and performed one‐to‐one matching based on propensity scores of each patient.</P><P><B>Results – </B> After PSM, all measured variables were well balanced in 1163 matched subjects, and the 90‐day case‐fatality was identical 6.2% (HR 0.997, 95%CI 0.905–1.099) in Sweden and Korea.</P><P><B>Conclusions – </B> No difference is found in the 90‐day case‐fatality in propensity score‐matched Swedish and Korean patients with ischemic stroke.</P>

Paenibacillus pueri sp. nov., isolated from Pu'er tea

Kim, B.-C.,Jeong, W.-J.,Kim, D. Y.,Oh, H.-W.,Kim, H.,Park, D.-S.,Park, H.-M.,Bae, K. S. Microbiology Society 2009 International journal of systematic and evolutiona Vol.59 No.5

<P>Pu'er tea is a fermented drink made from the leaves of the tea plant, Camellia sinensis. Two novel bacteria, designated strains b09i-3(T) and b13i-1, were isolated during the process of fermentation of this tea. These isolates were Gram-positive, endospore-forming, motile rods that grew at 25-42 degrees C and pH 5.5-10.4. The DNA G+C content was 56.6-58.4 mol%, the predominant isoprenoid quinone was MK-7 and the predominant cellular fatty acid was anteiso-C(15 : 0) (49.0-50 % of the total). Phylogenetic analysis based on 16S rRNA gene sequences showed that strains b09i-3(T) and b13i-1 shared 99.9 % similarity and were affiliated with a cluster within the family Paenibacillaceae. Strains b09i-3(T) and b13i-1 were related most closely to Paenibacillus ginsengihumi DCY16(T) (97 % 16S rRNA gene sequence similarity). Levels of DNA-DNA relatedness between the two novel isolates and P. ginsengihumi DCY16(T) were below 56 %. The phylogenetic and phenotypic characteristics of these novel isolates allowed them to be distinguished clearly from recognized species of the genus Paenibacillus. Based on these data, strains b09i-3(T) and b13i-1 are considered to represent a novel species of the genus Paenibacillus, for which the name Paenibacillus pueri sp. nov. is proposed. The type species is b09i-3(T) (=KCTC 13223(T)=CECT 7360(T)).</P>

원발성 간암에서 PIVKA-II 및 Lens Culinaris Agglutinin-A 반응성 Alpha-fetoprotein(AFP-L3)의 임상적 유용성

배시현,박두호,양진모,박영민,차상복,최종영,성광용,조세현,정규원,선희식,김부성,최상욱,변병훈,한남익 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.2

Background/Aims: Des-γ-carboxy prothrombin(DCP), a protein induced by vitamin K absence or antagonist-II(PIVKA-II), and Lens culinaris agglutinin-A reactive AFP-L3 have been reported to be useful markers for the diagnosis of hepatocellular carcinoma (HCC). In the present study, both the PIVKA-II and AFP-L3 were analyzed and compared with a conventional AFP to determine its usefulness, specificity and sensitivity in the diagnosis of HCC. Methods: Sera were collected from 108 patients consisting of 17 patients with chronic hepatitis, 22 patients with liver cirrhosis and 69 patients with HCC. The AFP-L3 was determined by an lectin affinity electrophoresis coupled with an antibody-affinity blotting. Level of DCP was measured by an enzyme immunoassay with an anti-DCP monoclonal antibody. Results: The sensitivity and specificity of PIVKA-II and AFP L3 were 49.3% and 89.5%, and 32.5% and 85.7%, respectively. No significant correlation was found between the PIVKA-II or AFP L3 and serum AFP. No correlation was found etween the PIVKA-II or AFP L3 and the characteristics of HCC. Conclusion: The determination of plasma DCP and AFP L3 levels combined with AFP levels may be useful especially for the differential diagnosis between HCC and chronic liver diseases without HCC.(Korean J HepatoBackground/Aims: Des-γ-carboxy prothrombin(DCP), a protein induced by vitamin K absence or antagonist-II(PIVKA-II), and Lens culinaris agglutinin-A reactive AFP-L3 have been reported to be useful markers for the diagnosis of hepatocellular carcinoma (HCC). In the present study, both the PIVKA-II and AFP-L3 were analyzed and compared with a conventional AFP to determine its usefulness, specificity and sensitivity in the diagnosis of HCC. Methods: Sera were collected from 108 patients consisting of 17 patients with chronic hepatitis, 22 patients with liver cirrhosis and 69 patients with HCC. The AFP-L3 was determined by an lectin affinity electrophoresis coupled with an antibody-affinity blotting. Level of DCP was measured by an enzyme immunoassay with an anti-DCP monoclonal antibody. Results: The sensitivity and specificity of PIVKA-II and AFP-L3 were 49.3% and 89.5%, and 32.5% and 85.7%, respectively. No significant correlation was found between the PIVKA-II or AFP-L3 and serum AFP. No correlation was found etween the PIVKA-II or AFP L3 and the characteristics of HCC. Conclusion: The determination of plasma DCP and AFP-L3 levels combined with AFP levels may be useful especially for the differential diagnosis between HCC and chronic liver diseases without HCC.(Korean J Hepatol 2000;6:205-214)l 2000;6:205-214)

CK2α/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients

Bae, J.S.,Park, S.H.,Jamiyandorj, U.,Kim, K.M.,Noh, S.J.,Kim, J.R.,Park, H.J.,Kwon, K.S.,Jung, S.H.,Park, H.S.,Park, B.H.,Lee, H.,Moon, W.S.,Sylvester, K.G.,Jang, K.Y. American Association of Pathologists and Bacteriol 2016 The American journal of pathology Vol.186 No.12

<P>Recently, the roles of sirtuins (SIRTs) in tumorigenesis have been of interest to oncologists, and protein kinase CK2 alpha 1 (CSNK2A1) has been shown to be involved in tumorigenesis by phosphorylating various proteins, including SIRT1. Therefore, we evaluated the roles of CSNK2A1, SIRT6, and phosphorylated SIRT6 and their relationships in breast carcinoma. Nuclear expression of CSNK2A1 and SIRT6 predicted shorter overall survival and relapse-free survival by multivariate analysis. Inhibition of CSNK2A1 decreased the proliferative and invasive activity of cancer cells. In addition, CSNK2A1 was bound to SIRT6 and phosphorylated SIRT6; evidence for this is provided from immunofluorescence staining, co-immunoprecipitation of CSNK2A1 and SIRT6, a glutathione S-transferase pull-down assay, an in vitro kinase assay, and transfection of mutant CSNK2A1. Knockdown of SIRT6 decreased the proliferation and invasiveness of cancer cells. Overexpression of SIRT6 increased proliferation, but mutation at the Ser338 phosphorylation site of SIRT6 inhibited the proliferation of MCF7 cells. Moreover, both knockdown of SIRT6 and a mutation at the phosphorylation site of SIRT6 decreased expression of matrix metallopeptidase 9, beta-catenin, cyclin D1, and NF-kappa B. Especially, SIRT6 expression was associated with the nuclear localization of B-catenin. This study demonstrates that CSNK2A1 and SIRT6 are indicators of poor prognosis for breast carcinomas and that CSNK2A1-mediated phosphorylation of SIRT6 might be involved in the progression of breast carcinoma.</P>

Electronic Band Structure and Photocatalytic Activity of M-Doped TiO2(M=Co and Fe)

M. G. Ha,H. G. Kim,B. H. Shon,E. D. Jeong,박혁규,J. H. Jung,이재성,M. S. Won,S. W. Bae 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.III

Cobalt- or iron-doped TiO2 nanocrystals were fabricated by the hydrothermal synthesis method. The electronic structure and optical properties of the materials were studied by using XRD, UVDRS, and the FP-LAPW (Full-Potential Linearized Augmented Plane Wave) method. The bandgap energy of Co- and Fe-doped TiO2 obtained by FP-LAPW and UV-DRS was ca. 2.6 and 2.5 eV, respectively. These doped materials absorbed visible light and exhibited photocatalytic activity for oxidative decomposition of CH3Cl to CO2 under visible light irradiation ( > 420 nm). However, only Fe-doped TiO2 showed the activity for CH3Cl degradation to CO2, probably due to its higher oxidation potential, as the FP-LAPW calculation indicated.

A multivariate receptor modeling study of air-borne particulate PAHs: Regional contributions in a roadside environment

Kim, B.M.,Lee, S.B.,Kim, J.Y.,Kim, S.,Seo, J.,Bae, G.N.,Lee, J.Y. Pergamon Press 2016 CHEMOSPHERE - Vol.144 No.-

Understanding the geographic source contributions by particulate polycyclic aromatic hydrocarbons (PAHs) is important for the Korean peninsula due to its downwind location from source areas. Regional influence of particulate PAHs was previously identified using diagnostic ratios applied to mobile source dominated roadside sampling data (Kim et al., 2012b). However, no study has yet been conducted to quantify the regional source contributions. We applied a multivariate receptor modeling tool to identify and quantify the regional source contributions to particulate PAHs in Seoul. Sampling of roadside particulate PAHs was conducted in Seoul, Korea for four years between May 2005 and April 2009, and data analysis was performed with a new multivariate receptor model, Solver for Mixture Problem (SMP). The SMP model identified two sources, local mobile source and transported regional source, and quantified their source contributions. Analysis of the particulate PAHs data reveals three types of episodic periods: a high regional source contribution period with one case, a high mobile source contribution period with three cases, and a normal contribution period with eight cases. Four-year average particulate PAHs source contributions from the two sources are 4.6 ng m<SUP>-3</SUP> and 10.7 ng m<SUP>-3</SUP> for regional and mobile sources, respectively and equivalent to 30% and 70% of the total estimated contribution from each of these sources.

Quality characteristics of common wheat fresh noodle with insoluble dietary fiber from kimchi by-product

Kim, B.R.,Kim, S.,Bae, G.S.,Chang, M.B.,Moon, B. ACADEMIC PRESS - JOURNALS DEPARTMENT 2017 FOOD SCIENCE AND TECHNOLOGY -ZURICH- Vol.85 No.PA

<P>This study aimed to investigate the quality of fresh noodles prepared using insoluble dietary fiber-enriched fractions (IEF) recovered from kimchi by-products (KBP) and common wheat flour, instead of semolina. Four samples (NICO, NIC2, NIC4, and NIC6) were prepared using common wheat flour mixed with different ratios of IEF (0 g/100 g; 2 g/100 g; 4 g/100 g; 6 g/100 g, respectively); Semolina pasta (SMP) was prepared as control. With increasing IEF ratios, cooking loss and swelling indexes increased significantly (p < 0.05). SEM images showed continuous and clear air pockets that were observed in NIC2 and SMP, whereas a loose protein network and big air pockets were observed in NIC4 and NIC6. After addition of IEF, L*, a*, and b* of samples decreased in all samples. Hardness of all samples in TPA was not statistically different regardless of the addition of IEF to common wheat flour. NIC2 showed the highest overall acceptability in sensory evaluation, while hardness, texture, color, taste, and flavor decreased in higher than 2 g/100 g (p < 0.05) IEF. Based on these results, fresh noodle using 2 g/100 g IEF from KBP and common wheat flour showed a great possibility to replace semolina pasta. (C) 2017 Elsevier Ltd. All rights reserved.</P>

Distribution and direct radiative forcing of black carbon aerosols over Korean Peninsula

Kim, M.Y.,Lee, S.B.,Bae, G.N.,Park, S.S.,Han, K.M.,Park, R.S.,Song, C.H.,Park, S.H. Pergamon Press ; Elsevier [distribution] 2012 Atmospheric environment Vol.58 No.-

Regional air quality modelling was used to simulate the distribution of BC aerosol over the Korean Peninsula for four mid-season months of 2009. Compared to ground-based and satellite observations, the model underestimated the average BC burden significantly, which might be attributed to inaccuracy in BC emissions inventories partly due to the neglect of the emissions from biomass burning although it is not possible to rule out inaccurate prediction of meteorology. The model-estimated monthly average BC burden was highest in winter because of the largest emission. When the BC burden was divided by the monthly emission factor, the adjusted BC burden was much higher in spring and fall than in winter and summer due to strong influence of Chinese source conveyed by westerly wind prevailing in spring and fall. Both long-range transport and local sources were shown to contribute to atmospheric BC over the Korean Peninsula. Urban areas were influenced more by local sources while the effect of long-range transport was higher in remote areas. Based on the model simulations, the direct radiative forcing (DRF) of BC was estimated to be 0.1-1.8 W m<SUP>-2</SUP> over the Korean Peninsula with the domain-average value of 0.39 W m<SUP>-2</SUP>. Accounting for the model underestimation of absorbing aerosol optical depth by BC by 48% compared to measured monthly averages due to the underestimated emissions inventories, the adjusted average DRF is 0.75 W m<SUP>-2</SUP>2.

Loganin protects against pancreatitis by inhibiting NF-κB activation

Kim, M.J.,Bae, G.S.,Jo, I.J.,Choi, S.B.,Kim, D.G.,Shin, J.Y.,Lee, S.K.,Kim, M.J.,Shin, S.,Song, H.J.,Park, S.J. North-Holland ; Elsevier Science Ltd 2015 european journal of pharmacology Vol.765 No.-

<P>Acute pancreatitis (AP) is an inflammatory disease of the pancreas, which, in its most severe form, is associated with multi-organ failure and death. Loganin, a major iridoid glycoside obtained from Corni fructus, has been shown to have anti-inflammatory and anti-shock effects. However, the effects of loganin on AP have not been determined. Pre-treatment of loganin reduced pancreatic damage and AP-associated lung injury and attenuated the severity of AP, as evidenced by (1) a reduction in several biochemical parameters (pancreatic weight to body weight ratio, myeloperoxidase activity, and level of amylase) and (2) production of pro-inflammatory cytokines such as interleukin (IL)-1 beta and tumor necrosis factor (INF)-alpha. However, post-treatment of loganin failed to improve pancreatic damage and biochemical parameters of AP, but could inhibit the AP-induced elevation of IL-1 beta and TNF-alpha significantly. In addition, cerulein-induced activation of nuclear factor (NF)-kappa B was inhibited in the pancreas by administration of loganin. In conclusion, these results suggest that loganin exhibits an anti-inflammatory effect in cases of AP and its pulmonary complications through inhibition of NF-kappa B activation. (C) 2015 Elsevier B.V. All rights reserved.</P>

Stabilized ordered-mesoporous Co₃O₄ structures using Al pillar for the superior CO hydrogenation activity to hydrocarbons

Ahn, C.I.,Koo, H.M.,Jo, J.M.,Roh, H.S.,Lee, J.B.,Lee, Y.J.,Jang, E.J.,Bae, J.W. Elsevier BV 2016 Applied Catalysis B Vol. No.

<P>The metal oxide pillared ordered-mesoporous Co3O4 was investigated to design a stable and superior catalyst for CO hydrogenation into linear hydrocarbons through Fischer Tropsch Synthesis (FTS) reaction. Enhanced structural stability was observed in ordered-mesoporous Co3O4 even under hydrogen-excess conditions after modification with a metal oxide pillar of Al2O3. The mesoporous Co3O4 was synthesized using a hard template of highly ordered three dimensional mesoporous KIT-6. A small number of metal oxide pillars such as Al2O3, Mn2O4, and SiO2 with 5 wt% were subsequently added to the orderedmesoporous Co3O4 through the incipient wetness impregnation method. The Al2O3-modifed mesoporous Co3O4 catalyst demonstrated superior CO conversion with a stable activity in CO hydrogenation reaction. The enhanced catalytic stability seems to be attributable to the lower mobility of the Al2O3 pillar which formed stronger interactions with the mesoporous Co3O4 inner surfaces. The Al2O3 modification can effectively stabilize ordered-mesoporous structures of Co3O4 by acting as an ordered mesoporous channel reactor and enhancing the transport rate of hydrocarbons formed during FTS reaction. (C) 2015 Elsevier B.V. All rights reserved.</P>