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- 저자 : B. F. Shu (검색결과 3 건)
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Hu, X -T,Zhang, F -B,Fan, Y -C,Shu, X -S,Wong, A H Y,Zhou, W,Shi, Q -L,Tang, H -M,Fu, L,Guan, X -Y,Rha, S Y,Tao, Q,He, C Macmillan Publishers Limited 2009 Oncogene Vol.28 No.26
Located at the important tumor suppressor locus, 3p22, PLCD1 encodes an enzyme that mediates regulatory signaling of energy metabolism, calcium homeostasis and intracellular movements. We identified PLCD1 as a downregulated gene in aerodigestive carcinomas through expression profiling and epigenetic characterization. We found that PLCD1 was expressed in all normal adult tissues but low or silenced in 84% (16/19) gastric cancer cell lines, well correlated with its CpG island (CGI) methylation status. Methylation was further detected in 62% (61/98) gastric primary tumors, but none of normal gastric mucosa tissues. PLCD1 methylation was significantly correlated with tumor high stage. Detailed methylation analysis of 37 CpG sites at the PLCD1 CGI by bisulfite genomic sequencing confirmed its methylation. PLCD1 silencing could be reversed by pharmacological demethylation with 5-aza-2′-deoxycytidine, indicating a direct epigenetic silencing. Ectopic expression of PLCD1 in silenced gastric tumor cells dramatically inhibited their clonogenicity and migration, possibly through downregulating MMP7 expression and hampering the reorganization of cytoskeleton through cofilin inactivation by phosphorylation. Thus, epigenetic inactivation of PLCD1 is common and tumor-specific in gastric cancer, and PLCD1 acts as a functional tumor suppressor involved in gastric carcinogenesis.Oncogene (2009) 28, 2466–2475; doi:10.1038/onc.2009.92; published online 18 May 2009
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Pan C.B.,Zhao G.C.,Li S.M.,Shu M.F.,Wu J.,Wang J.M.Z.,Yin L.H.,Song W.H.,Zhu X.B,Yang J.,Sun Y.P. 한국물리학회 2022 Current Applied Physics Vol.34 No.-
Among Aurivillius layer-structured materials, CaBi2Nb2O9 is a best potential candidate for ultrahigh-temperature applications because of its highest Curie temperature of about 940 ◦C. In this paper, (1-x)CaBi2Nb2O9- xBaZr0.2Ti0.8O3 composite ceramics were prepared by conventional solid-state sintering method. The dielectric results show that the introduction of BaZr0.2Ti0.8O3 not only increases the permittivity of the material, but also reduces its dielectric loss. The optimum electrical properties were obtained in the x = 0.01 sample with piezoelectric coefficient (d33) of 15.1 pC/N and high ferroelectric remnant polarization (Pr) of 9.9 μC/cm2. Furthermore, the composite samples show good thermal depoling performance, the d33 of the x = 0.01 sample is 13.8 pC/N, which is about 91% of the initial value after depoling at 800 ◦C. Therefore, (1-x)CaBi2Nb2O9- xBaZr0.2Ti0.8O3 is one of the candidates for high temperature piezoelectric materials.
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Numerical investigation on residual stress in photovoltaic laminates after lamination
Q. Z. Zhang,B. F. Shu,M. B. Chen,Q. B. Liang,C. Fan,Z. Q. Feng,P. J. Verlinden 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.2
A series of simulations were carried out to investigate the residual stress induced in the photovoltaic laminate during the cooling processafter lamination with a global model and several submodels. The simulations focus separately on the effects of the cooling rate, thecell layout and anisotropy on the residual stress and deformation of the photovoltaic laminate in a comparative manner with the finiteelement method. The results have shown that significant stress concentration and twist occurs in the interconnection region in the cell. Inaddition, different cooling rates, cell layouts and anisotropy only influence the largest stress rather than the stress distribution and deformation. Therefore, the results of a uniform stationary isotropic model with fewer cells can provide enough insight into the stress distributionin real photovoltaic laminates and the modified largest first principal stress can be used for design and verification.
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