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- 저자 : B. Brian Park (검색결과 4 건)
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Functional Subpopulations of Neurons in a Macaque Face Patch Revealed by Single-Unit fMRI Mapping
Park, Soo Hyun,Russ, Brian E.,McMahon, David B.T.,Koyano, Kenji W.,Berman, Rebecca A.,Leopold, David A. Elsevier 2017 Neuron Vol.95 No.4
<P><B>Summary</B></P> <P>Neurons within fMRI-defined face patches of the macaque brain exhibit shared categorical responses to flashed images but diverge in their responses under more natural viewing conditions. Here we investigate functional diversity among neurons in the anterior fundus (AF) face patch, combining whole-brain fMRI with longitudinal single-unit recordings in a local population (<1 mm<SUP>3</SUP>). For each cell, we computed a whole-brain correlation map based on its shared time course with voxels throughout the brain during naturalistic movie viewing. Based on this mapping, neighboring neurons showed markedly different affiliation with distant visually responsive areas and fell coarsely into subpopulations. Of these, only one subpopulation (∼16% of neurons) yielded similar correlation maps to the local fMRI signal. The results employ the readout of large-scale fMRI networks and, by indicating multiple functional domains within a single voxel, present a new view of functional diversity within a local neural population.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We compared responses of macaque face patch cells to fMRI activity across the brain </LI> <LI> Single neurons yielded diverse fMRI correlation maps in response to natural videos </LI> <LI> Maps generated by single units within <1 mm<SUP>3</SUP> in the AF face patch differed greatly </LI> <LI> Clustering neurons based on such maps revealed functional subpopulations within AF </LI> </UL> </P>
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Mixed Traffic of Connected-Automated and Human-Driven Vehicles
B. Brian Park,Zheng Chen 대한교통학회 2019 대한교통학회 학술대회지 Vol.80 No.-
본 발표는 일반차량들과 자율협력주행차량들이 함께 존재하는 상황에서 자율협력주행차량과 일반차량의 상호작용을 평가할 수 있는 통합된 시뮬레이션 모형을 설명하고, 혼재된 차량들의 성능을 향상할 수 있는 제어 방법론들에 대해서 논하고 시뮬레이션을 통해서 기존의 방법들과 비교한 결과를 보여줄 것이다. 통합 시뮬레이션 모형에서 중요한 요소들이 vehicle dynamics 모형, 센서 모델링, 통신 모형 그리고 휴먼운전자라는 것을 설명할 것이다. 또한, 기존의 자율협력주행 차들의 Cooperative Adaptive Cruise Control (CACC)은 일반차량을 만나면 Adaptive Cruise Control (ACC)로 제어를 해야하기 때문에 CACC의 효과를 얻지 못하는데, 본 연구에서 제안한 CACC with unconnected vehicle 제어방법은 기존의 ACC에 비해 훨씬 효율적으로 제어가 가능하며, Connected ACC 기능이 있는 일반차량도 CACC 차량이나 다른 connected 차량과 함께 움직일때 human CACC 제어 방법을 통해서 일반 운전자가 제어하는 챠량에 비해 훨씬 효율적인 제어가 가능하다는 것을 보여줄 것이다.
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박재형,Kenya Kusunose,Deborah H. Kwon,Margaret M. Park,James D. Thomas,Richard A. Grimm,Brian P. Griffin,Thomas H. Marwick,Zoran B. Popović 대한심장학회 2016 Korean Circulation Journal Vol.46 No.2
Background and Objectives Right ventricular longitudinal strain (RVLS) is a new parameter of RV function. We evaluated the relationship of RVLS by speckle-tracking echocardiography with functional and invasive parameters in pulmonary arterial hypertension (PAH) patients. Subjects and Methods Thirty four patients with World Health Organization group 1 PAH (29 females, mean age 45±13 years old). RVLS were analyzed with velocity vector imaging. Results Patients with advanced symptoms {New York Heart Association (NYHA) functional class III/IV} had impaired RVLS in global RV (RVLSglobal, -17±5 vs. -12±3%, p<0.01) and RV free wall (RVLSFW, -19±5 vs. -14±4%, p<0.01 to NYHA class I/II). Baseline RVLSglobal and RVLSFW showed significant correlation with 6-minute walking distance (r=-0.54 and r=-0.57, p<0.01 respectively) and logarithmic transformation of brain natriuretic peptide concentration (r=0.65 and r=0.65, p<0.01, respectively). These revealed significant correlations with cardiac index (r=-0.50 and r=-0.47, p<0.01, respectively) and pulmonary vascular resistance (PVR, r=0.45 and r=0.45, p=0.01, respectively). During a median follow-up of 33 months, 25 patients (74%) had follow-up examinations. Mean pulmonary arterial pressure (mPAP, 54±13 to 46±16 mmHg, p=0.03) and PVR (11±5 to 6±2 wood units, p<0.01) were significantly decreased with pulmonary vasodilator treatment. RVLSglobal (-12±5 to -16±5%, p<0.01) and RVLSFW (-14±5 to -18±5%, p<0.01) were significantly improved. The decrease of mPAP was significantly correlated with improvement of RVLSglobal (r=0.45, p<0.01) and RVLSFW (r=0.43, p<0.01). The PVR change demonstrated significant correlation with improvement of RVLSglobal (r=0.40, p<0.01). Conclusion RVLS correlates with functional and invasive hemodynamic parameters in PAH patients. Decrease of mPAP and PVR as a result of treatment was associated with improvement of RVLS.
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박재형,Kenya Kusunose,Deborah H. Kwon,Margaret M. Park,Serpil C. Erzurum,James D. Thomas,Richard A. Grimm,Brian P. Griffin,Thomas H. Marwick,Zoran B. Popović 대한심장학회 2015 Korean Circulation Journal Vol.45 No.5
Background and Objectives: Right ventricular longitudinal strain (RVLS) is a new parameter of RV function. We evaluated the relationship of RVLS by speckle-tracking echocardiography with functional and invasive parameters in pulmonary arterial hypertension (PAH) patients. Subjects and Methods: Thirty four patients with World Health Organization group 1 PAH (29 females, mean age 45±13 years old). RVLS were analyzed with velocity vector imaging. Results: Patients with advanced symptoms {New York Heart Association (NYHA) functional class III/IV} had impaired RVLS in global RV (RVLSglobal, -17±5 vs. -12±3%, p<0.01) and RV free wall (RVLSFW, -19±5 vs. -14±4%, p<0.01 to NYHA class I/II). Baseline RVLSglobal and RVLSFW showed significant correlation with 6-minute walking distance (r=-0.54 and r=-0.57, p<0.01 respectively) and logarithmic transformation of brain natriuretic peptide concentration (r=0.65 and r=0.65, p<0.01, respectively). These revealed significant correlations with cardiac index (r=-0.50 and r=-0.47, p<0.01, respectively) and pulmonary vascular resistance (PVR, r=0.45 and r=0.45, p=0.01, respectively). During a median follow-up of 33 months, 25 patients (74%) had follow-up examinations. Mean pulmonary arterial pressure (mPAP, 54±13 to 46±16 mmHg, p=0.03) and PVR (11±5 to 6±2 wood units, p<0.01) were significantly decreased with pulmonary vasodilator treatment. RVLSglobal (-12±5 to -16±5%, p<0.01) and RVLSFW (-14±5 to -18±5%, p<0.01) were significantly improved. The decrease of mPAP was significantly correlated with improvement of RVLSglobal (r=0.45, p<0.01) and RVLSFW (r=0.43, p<0.01). The PVR change demonstrated significant correlation with improvement of RVLSglobal (r=0.40, p<0.01). Conclusion: RVLS correlates with functional and invasive hemodynamic parameters in PAH patients. Decrease of mPAP and PVR as a result of treatment was associated with improvement of RVLS
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