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Software architecture and algorithm for reliable RPC for geo-distributed mobile computing systems
Khan, Asmat Ullah,Bagchi, Susmit North-Holland 2018 Future generations computer systems Vol.86 No.-
<P><B>Abstract</B></P> <P>Remote Procedure Call (RPC) is a computing as well as communication model for distributed processes to execute client routines on remote servers in the distributed systems. Due to the evolution of geo-distributed mobile cloud computing systems, mobile devices are exposed to frequent disconnection due to limited battery lifetime, processing capacity and network bandwidth while roaming globally. The existing standard RPC and mobile RPC frameworks are not completely suitable for applications in geo-distributed mobile cloud computing. This paper proposes a novel software architecture and associated algorithms for realizing reliable RPC under global mobility of clients. The stateful server chaining and multiple authentication primitives are employed in the proposed design to achieve security as well as location transparency. The software architecture is implemented on heterogeneous testbed and evaluated with promising results. The heterogeneity of mobile cloud platform is considered in the design by employing specific XDR format enhancing portability. A detailed comparative analysis of the proposed design is included in the paper.</P> <P><B>Highlights</B></P> <P> <UL> <LI> GMCC-RPC: Reliable mobile RPC for geo-distributed systems. </LI> <LI> Software architecture for mobile and reliable RPC for geo-distributed systems. </LI> <LI> Mobile and Reliable RPC using server chains in geo-distributed systems. </LI> </UL> </P>
Can a Sector-Wide Approach Underpin and Advance Universal Health Coverage?
Anar Ulikpan,Peter Hill,Asmat Ullah Malik,George Shakarishvili,Indermohan Narula 한국사회복지학회 2012 Asian Social Work and Policy Review Vol.6 No.1
Fragmented management approach makes the provision of comprehensive health care for achievinguniversal health coverage very unlikely. This article aims to explore the potential contributionof a systemic approach—the sector-wide approach (SWAp)—to achieving universal health coverage(UHC), using the Mongolian context as an example. The paper describes UHC and factors thathinder its achievement in developing countries, based on the Mongolian experience. The analysisfocuses on the root factors hindering the achievement of UHC and examines how these affect systemand local capacity critical for achieving UHC. Two principally different approaches, a sectorwide(holistic) approach and a standalone project (fragmented) approach are compared in terms oftheir contribution to the main indicators of achieving UHC. The current stage of the Mongolianhealth SWAp is identified and early rewards of a SWAp are presented. The paper proposes aSWAp as a potential approach to tackle these root factors to help in achieving UHC, because it isa promising instrument that promotes a systems-strengthening and capacity-building approachto enable effective coordination of standalone projects in alignment with the national priorities.
A Comprehensive Study of SARS-CoV-2: From 2019-nCoV to COVID-19 Outbreak
( Abdul Waris ),( Muhammad Ali ),( Atta Ullah Khan ),( Asmat Ali ),( Abdul Baset ) 한국미생물 · 생명공학회 2020 한국미생물·생명공학회지 Vol.48 No.3
The coronavirus disease 2019 (COVID-19) is a highly contagious pneumonia that has spread throughout the world. It is caused by a novel, single stranded RNA virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Genetic analysis revealed that, phylogenetically, the SARS-CoV-2 is related to severe acute respiratory syndrome-like viruses seen in bats. Because of this, bats are considered as a possible primary reservoir. The World Health Organization has declared the COVID-19 outbreak as a pandemic. As of May 27, 2020, more than 5,406,282 confirmed cases, and 343,562 confirmed deaths have been reported worldwide. Currently, there are no approved vaccines or antiviral drugs available against COVID-19. Newly developed vaccines are in the first stage of clinical trials, and it may take a few months to a few years for their commercialization. At present, remdesivir and chloroquine are the promising drugs for treating COVID-19 patients. In this review, we summarize the diversity, genetic variations, primary reservoirs, epidemiology, clinical manifestations, pathogenesis, diagnosis, treatment strategies, and future prospects with respect to controlling the spread of COVID-19.
Jingjing Wang,Qi Su,Qing Wu,Kun Chen,Asmat Ullah,Mohsin Ahmad Ghauri,Yanmin Zhang 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.11
Hepatocellular carcinoma (HCC) is one of themost common tumor types globally. Despite the progressmade in surgical procedures and therapeutic options, HCCremains a considerable cause of cancer-related mortality. In this study, we investigated the antitumor eff ects of sanguinarine(Sang) on HCC and its potential mechanisms. Our fi ndings showed that Sang impairs the acidic environmentof lysosomes by inhibiting cathepsin D maturation. Inaddition, Sang inhibited the formation of autolysosomes inRFP-GFP-LC3 transfected cells, subsequently suppressinglate mitophagy. Sang also induced reactive oxygen species(ROS)-dependent autophagy and apoptosis in HCC cells,which was signifi cantly attenuated following treatment witha ROS scavenger. Further investigation using autophagyinhibitors revealed that sanguinarine-induced mitochondrialdysfunction and mitophagy led to mitochondrial apoptosisin HCC cells. Immunohistochemical staining of sanguinarine-treated xenograft samples revealed that it initiated andblocked autophagy. In summary, our fi ndings suggest thatin HCC cells, Sang impairs lysosomal function and inducesROS-dependent mitophagy and apoptosis.