[PE-0011] Identification of quantitative trait loci for salinity tolerance in rice using Cheongcheong, Nagdong mapping population

Saleem Asif(Saleem Asif ),Rahmatullah Jan(Rahmatullah Jan),Kyung-Min Kim(Kyung-Min Kim) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

Quantitative Analyses of Esophageal Cancer Research in Pakistan

Qureshi, Muhammad Asif,Khan, Saeed,Ujjan, Ikram Din,Iqbal, Asif,Khan, Ramsha,Khan, Bilal Ahmed Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7

Background: Health-care research is a neglected discipline in Pakistan and research related to esophageal cancer (ranks 9th in Pakistani males and 5th in females) is no exception in this regard. Particularly, there are no data available to delineate the overall status of esophageal cancer epidemiological studies in Pakistan. This study describes the first ever effort to make a systematic quantification, in an attempt to provide a road-map to all stakeholders for designing appropriate epidemiological, diagnostic and therapeutic strategies. Materials and Methods: International (PubMed, ISI Web of Knowledge) and local (PakMedinet) scientific databases as well as Google search engine were searched using specified keywords to extract relevant publication. Well-defined inclusion criteria were implemented to select publications for final analyses. All data were recorded by at least 3 authors and consensus data were entered into and analyzed for descriptive statistics (such as frequencies, percentages and annual growth rates) using Microsoft Excel and SPSS software. Results: A total of 79 publications fulfilled the inclusion criteria including 20 publications for which full texts were not available. Of the 79 publications, 59 (74.6%) were original/research publications, 5 (6.3%) were case reports, 4 (5.1%) were research communications, 2 (2.5%) were review articles, 1 was (1.2%) correspondence and 8 (10.1%) were undefined categories. Only 13 (<20%) cities of Pakistan contributed towards the 79 publications. On average, only 1.9 relevant publications/year were published from 1976 (year of first publication) to the present. Alarmingly, a decline in the annual growth at -4.1% was recorded in the last six years. Conclusions: Esophageal cancer research is largely unfathomed in Pakistan. Urgent/dramatic steps are required by all concerned to address this common (and under reported) cancer of Pakistan.

FROM DETERRENCE AND COERCIVE DIPLOMACY TO WAR - THE 1971 CRISIS IN SOUTH ASIA

ASIF SIDDIQUI 서울대학교 국제학연구소 1997 Journal of International and Area Studies Vol.4 No.1

  This study will try to demarcate the reasons for India and Pakistan shifting from policies of coercive diplomacy and deterrence respectively to one of war. The research puzzle that this essay examines is: Why did two countries that were trying to avoid a war in the early part of 1971 engage in full-scale military hostilities before the year was over? Indirectly, this essay also sheds light on another puzzle: Why did the Pakistani leadership, which perceived that it was unlikely to defeat India in war, launch an attack from its western wing on December 3, 1971? The position taken in this study is that the cost/benefit analysis for each country shifted in fervor of war because of the strategic interaction between the two over the course of 1971.In sum, this essay adds to the body of literature elucidating reasons coercive diplomacy and deterrence can fail.

Prevalence, Risk Factors and Disease Knowledge of Breast Cancer in Pakistan

Asif, Hafiz Muhammad,Sultana, Sabira,Akhtar, Naveed,Rehman, Jalil Ur.,Rehman, Riaz Ur. Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11

Breast cancer is the most common cancer in females all over the world with approximately one million new cases each year as well as one of second leading causes of death among females. In Pakistan, the most frequently diagnosed cancer among females is also breast cancer, accounting for nearly one in nine female patients. Its incidence in Pakistan is 2.5 times higher than that in neighboring countries like Iran and India. The risk factors associated with breast cancer are age, family history, early menarche, intake of combined estrogen and progestin menopausal hormones, alcohol consumption, physical inactivity, low socioeconomic status and lack of awareness regarding the disease. This mini-review article aims to provide awareness about breast cancer as well as an updated knowledge about the prevalence, risk factors and disease knowledge of breast cancer in Pakistan.

Mid-upper-arm circumference as a screening measure for identifying children with elevated body mass index: a study for Pakistan

Asif, Muhammad,Aslam, Muhammad,Altaf, Saima The Korean Pediatric Society 2018 Clinical and Experimental Pediatrics (CEP) Vol.61 No.1

Purpose: Mid-upper-arm circumference (MUAC) is considered an alternative screening method for obesity. The aims of this investigation were to examine the ability of MUAC to correctly identify children with elevated body mass index (BMI) and to determine the best MUAC cutoff point for identification of children with high BMI. Methods: Anthropometric measurements (height, weight, and MUAC) from a cross-sectional sample of 7,921 Pakistani children aged 5-14 years were analyzed. Pearson correlation coefficients between MUAC and other anthropometric measurements were calculated. Receiver operating characteristic curve analysis was used to determine the optimal MUAC cutoff point for identifying children with high BMI. Results: Among 7,921 children, the mean (${\pm}$standard deviation) age, BMI, and MUAC were 10.00 (${\pm}2.86years$), 16.16 (${\pm}2.66kg/m^2$), and 17.73 (${\pm}2.59cm$), respectively. The MUAC had a strong positive correlation with BMI. The optimal MUAC cutoff points indicating elevated BMI in boys ranged from 16.76 to 22.73, while the corresponding values in girls ranged from 16.38 to 20.57. Conclusion: MUAC may be used as a simple indicator of overweight/obesity in children, with reasonable accuracy in clinical settings.

HER-2 Positive Breast Cancer - a Mini-Review

Asif, Hafiz Muhammad,Sultana, Sabira,Ahmed, Saeed,Akhtar, Naheed,Tariq, Muhammad Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4

Breast cancer is one of among all cancers with increased incidence, high mortality rate, and high economic and social costs. The the most common type of cancer among females worldwide, breast cancer is actually the uncontrolled proliferation of cells which attain malignancy. Recently it has shown that breast cancer contributes 11% among all types of cancer diagnosed globally on an annual basis and it is one of the leading causes of death among women. The human epidermal growth factor receptor 2 (HER-2) is a receptor tyrosine-protein kinase erbB-2 normally involved in the proliferation and division of breast cells. In some abnormal cases the HER2 gene does not work correctly and makes too many copies of itself. HER2-positive (HER2+) breast cancers constitute an aggressive type of breast cancer and tend to grow faster and are more likely to spread. However, therapies that specifically target HER2, such as Herceptin$^{(R)}$ (traztuzumab), are very effective. HER2 targeted therapies, has significantly improved the therapeutic outcome for patients with HER2 positive breast cancer.

Role of heavy metals in human health and particularly in respect to diabetic patients

Asif, Mohammad Cellmed Orthocellular Medicine and Pharmaceutical 2017 셀메드 (CellMed) Vol.7 No.1

Minerals are individual of the components of foods and are not produced in the body but essential for best possible health. Several essential metals are vital for the appropriate performance of various enzymes, transcriptional factors and proteins that are essential in various biochemical paths. Metals like zinc (Zn), magnesium (Mg), and manganese (Mn) are cofactors of hundreds of enzymes. Zn is involved in the synthesis and secretion of insulin from the pancreatic ${\beta}-cells$. Chromium (Cr) increases the insulin receptors activity on target tissues, mainly in muscle cells. Insulin hormone is required to maintain the blood glucose amount in normal range. Continual increase of blood serum glucose level leads to marked chronic hyperglycemia or diabetes mellitus. Deficiency of insulin or its resistance, blood glucose level exceeds the upper limit of the common range of 126 mg/dl. Poor glucose control and diabetes changes the levels of essential trace elements such as Zn, Mg, Mn, Cr, iron etc. by rising urinary excretion and their related decrease in the blood. The aim of this article to discusses the important roles of essential trace elements in particular perspective of type 2 diabetes.

Numerical Study of NOx Abatement Using Ozone Injection Integrated with Wet Absorption

Asif, Muhammad,Kim, Woo-Seung Taylor Francis 2014 Ozone: science & engineering Vol.36 No.5

Structural Behaviour and Fire Design of Duplex and Ferritic Stainless Steel CHS Stub Columns

Asif Mohammed,Katherine A. Cashell 한국강구조학회 2021 International Journal of Steel Structures Vol.21 No.4

This paper investigates the structural behaviour and design of duplex and ferritic stainless steel stub columns with a circular hollow cross-section (CHS) at elevated temperature. A numerical model is developed to supplement the limited test results on stainless steel CHS stub columns in the literature. Following validation, the numerical approach is employed to gain an understanding of the critical behavioural characteristics which have not previously been studied. In addition, the paper considers and extends the continuous strength method (CSM) to include duplex and ferritic stainless steel for CHS stub columns in fire. The CSM employs a base curve linking the cross-section resistance to its deformation capacity and implements an elastic, linear hardening material model. The cross-sectional resistances obtained from the proposed CSM are compared with those from the numerical analysis, as well as with the standardised procedures in the European, American and Australia/New Zealand design standards. It is demonstrated that CSM can lead to more accurate and less scattered strength predictions than current design codes.

Study of clinically used and recently developed antimycobacterial agents

Asif, Mohammad 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.1

Tuberculosis is one of most pervasive, respiratory transmitted diseases and has spread to every corner of the globe. According World Health Organization report, as much as one-third of the world's population is currently infected by tuberculosis. There has been considerable interest in the currently used antimycotubercular compounds to inhibit or prevent mycobacterium species. These mycobacterium species have developed resistant against currently used drugs and produced toxic effect on long duration of therapy. These agents have different structure and almost all compounds having heterocyclic ring having one and more than one heteroatoms. These observations have been guiding for the currently used and newly developed antitubercular agents that possess potent antimicrobial activity and their side effects, activity against multi drug resistance MDR, XDR mycobacterium, and also in patient co-infected with HIV/AIDS.