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- 저자 : Arisan, Elif Damla (검색결과 2 건)
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Ozfiliz, Pelin,Arisan, Elif Damla,Coker-Gurkan, Ajda,Obakan, Pinar,Eralp, Tugce Nur,Dinler-Doganay, Gizem,Palavan-Unsal, Narcin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
Background: Cisplatin, a DNA damaging agent, induces apoptosis through increasing DNA fragmentation. However, identification of intrinsic resistance molecules against Cisplatin is vital to estimate the success of therapy. Bag-1 (Bcl-2-associated anthanogene) is one anti-apoptotic protein involved in drug resistance impacting on therapeutic efficiency. Elevated levels of this protein are related with increase cell proliferation rates, motility and also cancer development. For this reason, we aimed to understand the role of Bag-1 expression in Cisplatin-induced apoptosis in HeLa cervix cancer cells. Cisplatin decreased cell viability in time- and dose-dependent manner in wt and Bag-1L+HeLa cells. Although, $10{\mu}M$ Cisplatin treatment induced cell death within 24h by activating caspases in wt cells, Bag-1L stable transfection protected cells against Cisplatin treatment. To assess the potential protective role of Bag-1, we first checked the expression profile of interacting anti-apoptotic partners of Bag-1. We found that forced Bag-1L expression prevented Cisplatin-induced apoptosis through acting on Mcl-1 expression, which was reduced after Cisplatin treatment in wt HeLa cells. This mechanism was also supported by the regulation of heat shock protein (Hsp) family members, Hsp90 and Hsp40, which were involved in the regulation Bag-1 interactome including several anti-apoptotic Bcl-2 family members and c-Raf.
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Aysegul Peksel,Inci Arisan,Refiye Yanardag 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.2
The purpose of this work is to assess the radical scavenging activity, acetylcholinesterase inhibition,and proline content of an aqueous extract from wild pistachio (Pistacia atlantica Desf.) leaves. The effect of aqueous extract on superoxide radical scavenging, hydroxyl radical scavenging, N,N-dimethyl-1,4-phenylendiammoniumdichloride (DMPD•+) radical scavenging, ABTS•+ radical scavenging, nitric oxide scavenging, and β-carotene bleaching activities was examined. This study found that the aqueous extract possesses considerable amounts of flavonoids (33.52±2.04 μg catechin equivalents/mg of extract). The effect of this extract in scavenging activity of hydroxyl radical and DMPD•+ was significantly better than that of ascorbic acid and butylated hydroxyanisole (BHA). The effect of the extract in superoxide and ABTS•+ was significantly similar than that of tested standard antioxidants. The proline content of the extract was found to be 0.54±0.01 μg proline/mg of extract. Aqueous extract of P. atlantica inhibited acetylcholinesterase activity effectively with IC50 value of 58.05±0.12 μg/mL.
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