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Arian Ehterami,Majid Salehi,Saeed Farzamfar,Hadi Samadian,Ahmad Vaez,Hamed Sahrapeyma,Sadegh Ghorbani 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.2
In the present study, we fabricated vitamin D 3 -loaded alginate hydrogel and assessed its wound healing capability in the animalmodel. The various concentrations of vitamin D3 were added to the pre-dissolved sodium alginate in deionized water andcross-linked by calcium carbonate in combination with D -glucono-δ-lactone. The microstructure, swelling behavior, weightloss, hemo- and cytocompatibility of the fabricated hydrogels were evaluated. In the last stage, the therapeutic effi cacy ofthe prepared hydrogels was evaluated in the full-thickness dermal wound model. The scanning electron microscopy imagesshowed that the prepared hydrogel was highly porous with the porosity of 89.2 ± 12.5% and contained the interconnectedpores. Weight loss assessment showed that the prepared hydrogel is biodegradable with the weight loss percentage of about89% in 14 days. The results showed that the prepared hydrogels were hemo- and cytocompatible. The animal study resultsimplied that alginate hydrogel/3000 IU vitamin D 3 group exhibited the highest wound closure present which was statisticallysignifi cant than the control group ( p < 0.05). Moreover, the histological examinations revealed that hydrogel containing3000 IU vitamin D3 had the best performance and induced the highest re-epithelialization and granular tissue formation. Allin all, this study suggests that alginate hydrogels with 3000 IU vitamin D 3 can be exploited as a potential wound dressingin skin tissue engineering.
Saeed Farzamfar,Majid Salehi,Arian Ehterami,Mahdi Naseri-Nosar,Ahmad Vaez,Amir-Hassan Zarnani,Hamed Sahrapeyma,Mohammad Reza Shokri,Mehdi Aleahmad 대한의용생체공학회 2018 Biomedical Engineering Letters (BMEL) Vol.8 No.4
This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation viadecellularized human amniotic membrane (DAM), for the promotion of skin excisional wound repair. The DAM wasseeded with MenSCs at the density of 3 9 104 cells/cm2 and implanted onto a rat’s 1.50 9 1.50 cm2 full-thicknessexcisional wound defect. The results of wound closure and histopathological examinations demonstrated that the MenSCseededDAM could significantly improve the wound healing compared with DAM-treatment. All in all, our data indicatedthat the MenSCs can be a potential source for cell-based therapies to regenerate skin injuries.
Majid Salehi,Maryam Niyakan,Arian Ehterami,Saeed Haghi-Daredeh,Simin Nazarnezhad,Ghasem Abbaszadeh-Goudarzi,Ahmad Vaez,Seyedeh Fatemeh Hashemi,Nariman Rezaei,Seyed Reza Mousavi 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.1
In this study, cinnamon (cin) was loaded into poly(ε-caprolactone)/gelatin (PCL/Gel) nanofi brous matrices in order to fabricatean appropriate mat to improve wound healing. Mats were fabricated from PCL/COLL [1:1 (w/w)] solution with 1, 5and 25% (w/v) of cinnamon. Prepared mats were characterized with regard to their microstructure, mechanical properties,porosity, surface wettability, water-uptake capacity, water vapor permeability, blood compatibility, microbial penetration andcellular response. The fabricated mats with and without cinnamon were used to treat the full-thickness excisional wounds inWistar rats. The results indicated that the amount of cinnamon had a direct eff ect on porosity, mechanical properties, wateruptake capacity, water contact angle, water vapor transmission rate and cell proliferation. In addition, the results of in vivostudy indicated that after 14 days, the wounds which were treated with PCL/Gel 5%cin had better wound closure (98%)among other groups. Our results suggest that the cinnamon can be used as a suitable material for wound healing.
Majid Salehi,Keyvan Shahporzadeh,Arian Ehterami,Hodays Yeganehfard,Heliya Ziaei,Mohammad Moein Azizi,Saeed Farzamfar,Amirreza Tahersoltani,Arash Goodarzi,Jafar Ai,Akbar Ahmadi 한국섬유공학회 2020 Fibers and polymers Vol.21 No.8
In the current study, selenium particles were loaded into poly(ε-caprolactone)/gelatin nanofibrous matrices in orderto fabricate a potential wound dressing. The mats were produced by electrospinning of poly(ε-caprolactone)/Gelatin (1:1(w/w)) solution supplemented with 1 and 10 % (w/v) of selenium particles. Prepared wound dressings were investigatedregarding their morphology, mechanical properties, surface wettability, water-uptake capacity, water vapor permeability,porosity, blood compatibility, microbial penetration test and cellular response. Dressings containing 1 % and 10 % seleniumand selenium free mats were chosen to treat the full-thickness excisional wounds in Wistar rats. The study revealed that after14 days, the wound closure of the mat containing 1 % selenium was about 95.5±6.38 % while wound closure of the negativecontrol group was about 48.83±4.03 %. Our results showed the capability of nanofibrous containing selenium for successfulwound treatment.
A novel hydrogel containing 4-methylcatechol for skin regeneration: in vitro and in vivo study
Jilla Majidi Ghatar,Arian Ehterami,Simin Nazarnezhad,Maryam Sadat Hassani,Nariman Rezaei Kolarijani,Solmaz Mahami,Majid Salehi 대한의용생체공학회 2023 Biomedical Engineering Letters (BMEL) Vol.13 No.3
Skin damages are usual physical injuries and different studies have been done to improve wound healing. Hydrogel dueto its properties like a moist environment and cooling wound site is a good option for wound treatment. In this study, weevaluated the consequence of using alginate/chitosan hydrogel contained various dosages of 4-Methylcatechol (0, 0.1, 1%(W/W)) on wound healing. After hydrogel fabrication, different tests like SEM, swelling, release, weight loss, and hemoandcytocompatibility were done to characterize fabricated hydrogels. Finally, the rat model was used to assess Alginate/Chitosan hydrogel's therapeutic function containing 0.1 and 1% of 4-Methylcatechol. The pore size of hydrogel was between24.5 ± 9 and 62.1 ± 11.63 μm and about 90% of hydrogel was lost after 14 days in the weight loss test. Blood compatibilityand MTT assay showed that hydrogels were nontoxic and improved cell proliferation. In vivo test showed that Alginate/Chitosan/0.1%4-Methylcatechol improved wound healing and the results were significantly better than the gauze-treatedwound. Our results showed dose depending effect of 4-Methylcatechol on wound healing. This study shows the treatmenteffect of 4-Methylcatechol on wound healing and the possibility of using it for treating skin injuries.