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Immunomodulatory properties of stem cells and bioactive molecules for tissue engineering
Molina, Eric R.,Smith, Brandon T.,Shah, Sarita R.,Shin, Heungsoo,Mikos, Antonios G. Elsevier 2015 Journal of controlled release Vol.219 No.-
<P><B>Abstract</B></P> <P>The immune system plays a crucial role in the success of tissue engineering strategies. Failure to consider the interactions between implantable scaffolds, usually containing cells and/or bioactive molecules, and the immune system can result in rejection of the implant and devastating clinical consequences. However, recent research into mesenchymal stem cells, which are commonly used in many tissue engineering applications, indicates that they may play a beneficial role modulating the immune system. Likewise, direct delivery of bioactive molecules involved in the inflammatory process can promote the success of tissue engineering constructs. In this article, we will review the various mechanisms in which modulation of the immune system is achieved through delivered bioactive molecules and cells and contextualize this information for future strategies in tissue engineering.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lee, Esther J.,Huh, Beom Kang,Kim, Se Na,Lee, Jae Yeon,Park, Chun Gwon,Mikos, Antonios G.,Choy, Young Bin Elsevier 2017 Progress in materials science Vol.89 No.-
<P><B>Abstract</B></P> <P>The plentiful assortment of natural and synthetic materials can be leveraged to accommodate diverse wound types, as well as different stages of the healing process. An ideal material is envisioned to promote tissue repair with minimal inconvenience for patients. Traditional materials employed in the clinical setting often invoke secondary complications, such as infection, pain, foreign body reaction, and chronic inflammation. This review surveys the repertoire of surgical sutures, wound dressings, surgical glues, orthopedic fixation devices and bone fillers with drug eluting capabilities. It highlights the various techniques developed to effectively incorporate drugs into the selected material or blend of materials for both soft and hard tissue repair. The mechanical and chemical attributes of the resultant materials are also discussed, along with their biological outcomes <I>in vitro</I> and/or <I>in vivo</I>. Perspectives and challenges regarding future research endeavors are also delineated for next-generation wound repair materials.</P>
Materials from Mussel-Inspired Chemistry for Cell and Tissue Engineering Applications
Madhurakkat Perikamana, Sajeesh Kumar,Lee, Jinkyu,Lee, Yu Bin,Shin, Young Min,Lee, Esther J.,Mikos, Antonios G.,Shin, Heungsoo American Chemical Society 2015 Biomacromolecules Vol.16 No.9
<P>Current advances in biomaterial fabrication techniques have broadened their application in different realms of biomedical engineering, spanning from drug delivery to tissue engineering. The success of biomaterials depends highly on the ability to modulate cell and tissue responses, including cell adhesion, as well as induction of repair and immune processes. Thus, most recent approaches in the field have concentrated on functionalizing biomaterials with different biomolecules intended to evoke cell- and tissue-specific reactions. Marine mussels produce mussel adhesive proteins (MAPs), which help them strongly attach to different surfaces, even under wet conditions in the ocean. Inspired by mussel adhesiveness, scientists discovered that dopamine undergoes self-polymerization at alkaline conditions. This reaction provides a universal coating for metals, polymers, and ceramics, regardless of their chemical and physical properties. Furthermore, this polymerized layer is enriched with catechol groups that enable immobilization of primary amine or thiol-based biomolecules via a simple dipping process. Herein, this review explores the versatile surface modification techniques that have recently been exploited in tissue engineering and summarizes polydopamine polymerization mechanisms, coating process parameters, and effects on substrate properties. A brief discussion of polydopamine-based reactions in the context of engineering various tissue types, including bone, blood vessels, cartilage, nerves, and muscle, is also provided.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2015/bomaf6.2015.16.issue-9/acs.biomac.5b00852/production/images/medium/bm-2015-00852b_0006.gif'></P>