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- 저자 : Anoop Kumar Gupta (검색결과 2 건)
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Anoop Kumar Gupta,Sanjay Gupta,Rajendra Prasad Chhabra 한국유변학회 2017 Korea-Australia rheology journal Vol.29 No.3
In this work, the buoyancy-induced convection from an isothermal spheroid is studied in a Bingham plastic fluid. Extensive results on the morphology of approximate yield surfaces, temperature profiles, and the local and average Nusselt numbers are reported to elucidate the effects of the pertinent dimensionless parameters: Rayleigh number, 102 ≤ Ra ≤ 10 6; Prandtl number, 20 ≤ Pr ≤ 100; Bingham number, 0 ≤ Bn ≤ 10 3, and aspect ratio, 0.2 ≤ e ≤ 5. Due to the fluid yield stress, fluid-like (yielded) and solid-like (unyielded) regions coexist in the flow domain depending upon the prevailing stress levels vis-a-vis the value of the fluid yield stress. The yielded parts progressively grow in size with the rising Rayleigh number while this tendency is countered by the increasing Bingham and Prandtl numbers. Due to these two competing effects, a limiting value of the Bingham number (Bnmax) is observed beyond which heat transfer occurs solely by conduction due to the solid-like behaviour of the fluid everywhere in the domain. Such limiting values bear a positive dependence on the Rayleigh number (Ra) and aspect ratio (e). In addition to this, oblate shapes (e < 1) foster heat transfer with respect to spheres (e = 1) while prolate shapes (e > 1) impede it. Finally, simple predictive expressions for the maximum Bingham number and the average Nusselt number are developed which can be used to predict a priori the overall heat transfer coefficient in a new application. Also, a criterion is developed in terms of the composite parameter which predicts the onset of convection in such fluids. Similarly, another criterion is developed which delineates the conditions for the onset of settling due to buoyancy effects. The paper is concluded by presenting limited results to delineate the effects of viscous dissipation and the temperature-dependent viscosity on the Nusselt number. Both these effects are seen to be rather small in Bingham plastic fluids.
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Meenakshi Gupta,Ruchika Sharma,Anoop Kumar 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.3
In the current investigation, we have compared the potential of statin drugs (Simvastatin, Rosuvastatin and Fluvastatin) as potential anti-bacterial agent by conducting in silico, in vitro and ex vivo studies. In silico study was conducted to check the interaction of statin drugs towards various targets of bacteria. The percentage growth retardation, bacterial growth kinetics, MIC determination, post antibiotic efect and bioflm formation assay were conducted to check the anti-bacterial efect of statin drugs under in vitro conditions. Finally, MTT assay was used to check the percentage of immune cell viability after Simvastatin treatment. Docking studies have revealed good interaction of Simvastatin, Rosuvastatin and Fluvastatin towards various targets of bacterial strains as that of the internal ligand. Simvastatin has shown good antibacterial activity against S. aureus, B. pumilus, P. aeruginosa and S. enterica as compared to Rosuvastatin and Fluvastatin. In vitro results have shown concentration and time dependent inhibition of bacterial growth by Simvastatin in concentration range of 64–256 μg/ml. Finally, MTT assay have shown non-cytotoxic efect of Simvastatin against adaptive immune system. In conclusion, Simvastatin could be a potential candidate as an anti-bacterial agent against a wide range of bacterial infections. However, further studies are required to check its complete role before starting phase I clinical trial.
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