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Jos Verbeek,Christina Mischke,Rachel Robinson,Sharea Ijaz,Paul Kuijer,Arthur Kievit,Anneli Ojajärvi,Kaisa Neuvonen 한국산업안전보건공단 산업안전보건연구원 2017 Safety and health at work Vol.8 No.2
Background: Osteoarthritis of the knee is considered to be related to knee straining activities at work. The objective of this review is to assess the exposure dose-response relation between kneeling or squatting, lifting, and climbing stairs at work, and knee osteoarthritis. Methods: We included cohort and caseecontrol studies. For each study that reported enough data, we calculated the odds ratio (OR) per 5,000 hours of cumulative kneeling and per 100,000 kg of cumulative lifting. We pooled these incremental ORs in a random effects meta-analysis. Results: We included 15 studies (2 cohort and 13 caseecontrol studies) of which nine assessed risks in more than two exposure categories.We considered all but one study at high risk of bias. The incremental OR per 5,000 hours of kneeling was 1.26 (95% confidence interval 1.17e1.35, 5 studies, moderate quality evidence) for a log-linear exposure dose-response model. For lifting, there was no exposure doseresponse per 100,000 kg of lifetime lifting (OR 1.00, 95% confidence interval 1.00e1.01). For climbing, an exposure dose-response could not be calculated. Conclusion: There is moderate quality evidence that longer cumulative exposure to kneeling or squatting at work leads to a higher risk of osteoarthritis of the knee. For other exposure, there was no exposure dose-response or there were insufficient data to establish this. More reliable exposure measurements would increase the quality of the evidence.