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- 저자 : Ana Krtolica (검색결과 1 건)
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Sangkyung Choen,Michael S. Kent,Abhijit J. Chaudhari,Simon R. Cherry,Ana Krtolica,Allison L. Zwingenberger 대한핵의학회 2023 핵의학 분자영상 Vol.57 No.1
Purpose We evaluated the kinetics of the hypoxia PET radiotracers, [18F]fluoromisonidazole ([18F]FMISO) and [18F]fluoroazomycin-arabinoside ([18F]FAZA), for tumor hypoxia detection and to assess the correlation of hypoxic kineticparameters with static imaging measures in canine spontaneous tumors. Methods Sixteen dogs with spontaneous tumors underwent a 150-min dynamic PET scan using either [18F]FMISO or [18F]FAZA. The maximum tumor-to-muscle ratio (TMRmax) > 1.4 on the last image frame was used as the standard thresholdto determine tumor hypoxia. The tumor time-activity curves were analyzed using irreversible and reversible two-tissuecompartment models and graphical methods. TMRmaxwas compared with radiotracer trapping rate (k3), influx rate (Ki), anddistribution volume (VT). Results Tumor hypoxia was detected in 7/8 tumors in the [18F]FMISO group and 4/8 tumors in the [18F]FAZA group. Allhypoxic tumors were detected at > 120 min with [18F]FMISO and at > 60 min with [18F]FAZA. [18F]FAZA showed betterfit with the reversible model. TMRmaxwas strongly correlated with the irreversible parameters (k3 and Ki) for [18F]FMISOat > 90 min and with the reversible parameter (VT) for [18F]FAZA at > 120 min. Conclusions Our results showed that [18F]FAZA provided a promising alternative radiotracer to [18F]FMISO with detectingthe presence of tumor hypoxia at an earlier time (60 min), consistent with its favorable faster kinetics. The strong correlationbetween TMRmaxover the 90–150 min and 120–150 min timeframes with [18F]FMISO and [18F]FAZA, respectively, withkinetic parameters associated with tumor hypoxia for each radiotracer, suggests that a static scan measurement (TMRmax) isa good alternative to quantify tumor hypoxia.
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