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      • GPU-accelerated Large Scale Analytics using MapReduce Model

        RadhaKishan Yadav,Robin Singh Bhadoria,Amit Suri 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.6

        Analysis and clustering of very large scale data set has been a complex problem. It becomes increasingly difficult to compute the results in a reasonable amount of time as data amount increases and with its feature dimensions. The GPU (graphics processing unit) has been a point of attraction in a last few years for its ability to compute highly-parallel and semi-parallel problems way faster than any traditional sequential processor. This paper explores the capability of GPU with MapReduce Model. This highly scalable model for distributed programming can be scaled upto thousands of machines. This was developed by Google’s developers Jeffrey Dean and Sanjay Ghemawat and has been implemented in many programming languages and frameworks like Apache Hadoop, Hive, and Pig etc. For this paper we’ll mainly focus on Hadoop framework. First two sections present the introduction and background. The working mechanism of this combination has been shown in section 3. Then further we explore frameworks present to implement MapReduce on GPU. In section 5, a comparative experiment was performed on GPU and CPU, both implementing MapReduce Model. The paper ends conclusion.

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        Curcuma zedoaria (christm.) roscoe inhibits proliferation of MDA‑MB231 cells via caspase‑cascade apoptosis

        Romen Meitei Lourembam,Amit Singh Yadav,Gopal C. Kundu,Pranab Behari Mazumder 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.3

        Curcuma zedoaria is a perennial herb that belongs to Zingiberaceae family, found growing lavishly in Manipur; a north eastern part of India. The traditional usages of the plant is not limited to a particular disease but extended over a large number of diseases. Anti-breast cancer activity of ethyl acetate extract of Curcuma zedoaria was conducted on MDA-MB231 breast cancer cell line with the help of MTT assay technique and the mechanistic pathway was established with the help of western blot technique, confocal microscopy, wound healing migration assay and cell cycle analysis. Cell cytotoxicity test of ethyl acetate extracts showed remarkable result on MDA-MB231 in dose dependent manner (p<0.05). Confocal microscopy studies on MDA-MB231 cells revealed the activation of cleaved caspase 9 in treated cells. Western blot analyses confrm the regulation of cytochrome C and suppression of Bcl-2 in treated cells which suggest ethyl acetate extract of Curcuma zedoaria inhibits the cancer cells through cascase-dependent pathways. In cell cycle analysis, after the treatments of the cells; there was an increase in the percentage of SubG0/G1 cells that decreased S and G2 phase indicating the population undergoing cell death (apoptosis or necrosis) thereby, our data suggest that ethyl acetate extracts were able to induce signifcant apoptosis in MDA-MB-231 cells in dose dependent manner. The wound healing migration assay confrms the anti-metastatic nature of the plant extract. With the help one way ANOVA test, all the experiments were executed and it was found that ethyl acetate extract of Curcuma zedoaria inhibits MDA-MB231 cells with the down-regulation of the expression of Bcl-2 through cascase-dependent pathways therefore Curcuma zedoaria is a potent anti-cancer plant especially in breast cancer.

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