New formulation of vitamin C encapsulation by nanoliposomes: production and evaluation of particle size, stability and control release

Samaneh Amiri,Mahmoud Rezazadeh-Bari,Mohammad Alizadeh-Khaledabad,Saber Amiri 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.2

In the present study, the effects of differentratios of milk phospholipids, cholesterol and phytosterols(Campesterol) powder (50–100%, 0–50%, and 0–50%,respectively) and sonication time (20, 25, 30, 35 and40 min) were investigated to produce a new formulation ofnanoliposomes for encapsulation of vitamin C. The resultsshowed that increasing the time of sonication anddecreasing the ratio of phospholipid to phytosterol significantlydecreased nanoliposomes’ particle size (p\0.05). The maximum encapsulation efficiency was obtained at 35and 40 min of sonication time and 75–25 ratio of phospholipid:phytosterol. Also, reducing the sonication time inthe same ratio of phospholipid/phytosterol caused toincrease the controlled release. The highest stability ofvitamin C during 20 days was obtained in the ratio of75–25 (phospholipids: campesterol). The results showed apositive effect of cholesterol replacement with campesterolon encapsulation efficiency, control release and stability ofvitamin C in nanoliposomes.

Simulation of earthquake records using combination of wavelet analysis and non-stationary Kanai-Tajimi model

Amiri, G. Ghodrati,Bagheri, A. Techno-Press 2009 Structural Engineering and Mechanics, An Int'l Jou Vol.33 No.2

This paper is aimed at combining wavelet multiresolution analysis and nonstationary Kanai-Tajimi model for the simulation of earthquake accelerograms. The proposed approach decomposes earthquake accelerograms using wavelet multiresolution analysis for the simulation of earthquake accelerograms. This study is on the basis of some Iranian earthquake records, namely Naghan 1977, Tabas 1978, Manjil 1990 and Bam 2003. The obtained results indicate that the simulated records preserve the significant properties of the actual accelerograms. In order to investigate the efficiency of the model, the spectral response curves obtained from the simulated accelerograms have been compared with those from the actual records. The results revealed that there is a good agreement between the response spectra of simulated and actual records.

Preparation, Characterization and Cytotoxicity of Silibinin-Containing Nanoniosomes in T47D Human Breast Carcinoma Cells

Amiri, Boshra,Ebrahimi-Far, Meysam,Saffari, Zahra,Akbarzadeh, Azim,Soleimani, Esmaeil,Chiani, Mohsen Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8

Background: Breast cancer is one of the most frequent cancer types within female populations. Silibinin is a chemotherapeutic agent ative against cancer. Niosomes are biodegradable, biocompatible, safe and effective carriers for drug delivery. Objective:To prepare nanoniosomal silibinin and evaluate its cytotoxicity inthe T-47D breast cancer cell line. Materials and Methods: Niosomes were prepared by reverse phase evaporation of a mixture of span 20, silibinin, PEG-2000 and cholesterol in chloroform and methanol solvent (1:2 v/v). The solvent phase was evaporated using a rotary evaporator and the remaining gel phase was hydrated in phosphate buffer saline. Mean size, size distribution and zeta potential of niosomes were measured with a Zetasizer instrument and then nanoparticles underwent scanning electron microscopy. The drug releasing pattern was evaluated by dialysis and the cytotoxicity of nanoniosomes in T-47D cells was assessed by MTT assay. Results: Particle size, size variation and zeta potential of the niosomal nanoparticles were measured as $178.4{\pm}5.4nm$, $0.38{\pm}0.09$ and $-15.3{\pm}1.3mV$, respectively. The amount of encapsulated drug and the level of drug loading were determined $98.6{\pm}2.7%$ and $22.3{\pm}1.8%$, respectively; released drug was estimated about $18.6{\pm}2.5%$ after 37 hours. The cytotoxic effects of nanoniosome were significantly increased when compared with the free drug. Conclusions: This study finding suggests that silibinin nanoniosomes could serve as a new drug formulation for breast cancer therapy.

Application of wavelet multiresolution analysis and artificial intelligence for generation of artificial earthquake accelerograms

Amiri, G. Ghodrati,Bagheri, A. Techno-Press 2008 Structural Engineering and Mechanics, An Int'l Jou Vol.28 No.2

This paper suggests the use of wavelet multiresolution analysis (WMRA) and neural network for generation of artificial earthquake accelerograms from target spectrum. This procedure uses the learning capabilities of radial basis function (RBF) neural network to expand the knowledge of the inverse mapping from response spectrum to earthquake accelerogram. In the first step, WMRA is used to decompose earthquake accelerograms to several levels that each level covers a special range of frequencies, and then for every level a RBF neural network is trained to learn to relate the response spectrum to wavelet coefficients. Finally the generated accelerogram using inverse discrete wavelet transform is obtained. An example is presented to demonstrate the effectiveness of the method.

New development of artificial record generation by wavelet theory

Amiri, G. Ghodrati,Ashtari, P.,Rahami, H. Techno-Press 2006 Structural Engineering and Mechanics, An Int'l Jou Vol.22 No.2

Nowadays it is very necessary to generate artificial accelerograms because of lack of adequate earthquake records and vast usage of time-history dynamic analysis to calculate responses of structures. According to the lack of natural records, the best choice is to use proper artificial earthquake records for the specified design zone. These records should be generated in a way that would contain seismic properties of a vast area and therefore could be applied as design records. The main objective of this paper is to present a new method based on wavelet theory to generate more artificial earthquake records, which are compatible with target spectrum. Wavelets are able to decompose time series to several levels that each level covers a specific range of frequencies. If an accelerogram is transformed by Fourier transform to frequency domain, then wavelets are considered as a transform in time-scale domain which frequency has been changed to scale in the recent domain. Since wavelet theory separates each signal, it is able to generate so many artificial records having the same target spectrum.

New method for generation of artificial ground motion by a nonstationary Kanai-Tajimi model and wavelet transform

Amiri, G. Ghodrati,Bagheri, A.,Fadavi, M. Techno-Press 2007 Structural Engineering and Mechanics, An Int'l Jou Vol.26 No.6

Considering the vast usage of time-history dynamic analyses to calculate structural responses and lack of sufficient and suitable earthquake records, generation of artificial accelerograms is very necessary. The main target of this paper is to present a novel method based on nonstationary Kanai-Tajimi model and wavelet transform to generate more artificial earthquake records, which are compatible with target spectrum. In this regard, the generalized nonstationary Kanai-Tajimi model to include the nonstationary evaluation of amplitude and dominant frequency of ground motion and properties of wavelet transform is used to generate ground acceleration time history. Application of the method for El Centro 1940 earthquake and two Iranian earthquakes (Tabas 1978 and Manjil 1990) is presented. It is shown that the model and identification algorithms are able to accurately capture the nonstationary features of these earthquake accelerograms. The statistical characteristics of the spectral response of the generated accelerograms are compared with those for the actual records to demonstrate the effectiveness of the method. Also, for comparison of the presented method with other methods, the response spectra of the synthetic accelerograms compared with the models of Fan and Ahmadi (1990) and Rofooei et al. (2001) and it is shown that the response spectra of the synthetic accelerograms with the method of this paper are close to those of actual earthquakes.

Modeling the Relationship between Land Cover and River Water Quality in the Yamaguchi Prefecture of Japan

Amiri, Bahman Jabbarian,Nakane, Kaneyuki The Ecological Society of Korea 2006 Journal of Ecology and Environment Vol.29 No.4

This study investigated the relationship between land cover and the water quality variables in the rivers, which are located in the Yamaguchi prefecture of West Japan. The study area included 12 catchments covering $5,809\;Km^2$. pH, dissolved oxygen, suspended solid, E. coli, total nitrogen and total phosphorus were considered as river water quality variables. Satellite data was applied to generate land cover map. For linking alterations in land cover (at whole catchment and buffer zone levels) and the river water quality variables, multiple regression modeling was applied. The results indicated that non-spatial attribute (%) of land cover types (at whole catchment level) consistently explained high amounts of variation in biological oxygen demand (72%), suspended solid (72%) and total nitrogen (87%). At buffer zone-scale, multiple regression models that were developed to represent the linkage between the alterations of land cover and the river water quality variables could also explain high level of total variations in suspended solid (86%) and total nitrogen (91%).

Modeling the Relationship between Land Cover and River Water Quality in the Yamaguchi Prefacture of Japan

Amiri, Bahman Jabbarian,Kaneyuki Nakane 한국생태학회 2006 Journal of Ecology and Environment Vol.29 No.4

This study investigated the relationship between land cover and the water quality variables in therivers, which are located in the Yamaguchi prefecture of West Japan. The study area included 12 catchmentscovering 5,809 Km2. pH, dissolved oxygen, suspended solid, E. coli, total nitrogen and total phosphorus wereconsidered as river water quality variables. Satellite data was applied to generate land cover map. For linkingalterations in land cover (at whole catchment and buffer zone levels) and the river water quality variables,(at whole catchment level) consistently explained high amounts of variation in biological oxygen demand (72%),suspended solid (72%) and total nitrogen (87%). At buffer zone-scale, multiple regression models that weredeveloped to represent the linkage between the alterations of land cover and the river water quality variablescould also explain high level of total variations in suspended solid (86%) and total nitrogen (91%).

The Impact of Feudalism and Racialism on The Construction of Self- and Gender Identities in Mohamed S. Mohamed’s Kiu and Nyota ya Rehema

Amiri Swaleh 한국외국어대학교 아프리카연구소 2020 Asian Journal of African Studies Vol.- No.47

This paper analyses and evaluates the impact of feudalism and racialism on the mapping and construction of self- and gender identities in Mohamed S. Mohamed’s two novels: Kiu (1972) and Nyota ya Rehema (1976). The study will use a composite approach comprising New Historicism, Gender Criticism and Stylistics. New Historicism helped to situate and map the works analyzed in relation to particular Zanzibari epochs. Gender Criticism was expended in interrogating how women and men in feudal Zanzibari society related with each other at all levels of social interaction and the impact on their self- and gender identities. Finally, stylistics was used to interrogate and evaluate the dominant structural and stylistic features of the choice texts and their impact on the study topic.The study will be guided by two hypotheses, viz, that in feudal Zanzibari society, racialism and the dominant ideologies (patriarchy, feudalism and racialism), impacted negatively on the self- and gender identities of both female and male members of Zanzibari society. Secondly, this study contends that, the stylistic devices used in each one of the choice texts, were important in delineating the mapping and construction of self- and gender identities..

Inhibitory Effects of Cyrtopodion scabrum Extract on Growth of Human Breast and Colorectal Cancer Cells

Amiri, Ahmad,Namavari, Mehdi,Rashidi, Mojtaba,Fahmidehkar, Mohammad Ali,Seghatoleslam, Atefeh Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

Breast and colorectal cancers rank high in Iran as causes of mortality. Most of the current treatments are expensive and non-specific. The potential anticancer properties of common home gecko, Cyrtopodion scabrum, were investigated in this study. The effects of C. scabrum extract on proliferation, viability and migration of the colorectal cancer (SW-742), breast cancer (MCF-7) and normal (MSC) cell lines were investigated using MTT and in vitro wound healing assay. $IC_{50}$ values calculated for the extract were $559{\pm}28.9{\mu}g/mL$ for MCF-7 and $339{\pm}11.3{\mu}g/mL$ for SW-742. No toxic effects on the normal control cells were observed. MCF-7 and SW-742 cell growth was inhibited by 32.6% and 62%, under optimum conditions, compared to the untreated control cells. The extract also decreased the motility and migration ability of both cancer cell lines, with no significant effects on the normal control cells. Data suggest C. scabrum extract as a useful natural resource for targeting cancer cells specifically.