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Centrifugal microfluidics for biomedical applications
Gorkin, Robert,Park, Jiwoon,Siegrist, Jonathan,Amasia, Mary,Lee, Beom Seok,Park, Jong-Myeon,Kim, Jintae,Kim, Hanshin,Madou, Marc,Cho, Yoon-Kyoung Royal Society of Chemistry 2010 Lab on a chip Vol.10 No.14
<P>The centrifugal microfluidic platform has been a focus of academic and industrial research efforts for almost 40 years. Primarily targeting biomedical applications, a range of assays have been adapted on the system; however, the platform has found limited commercial success as a research or clinical tool. Nonetheless, new developments in centrifugal microfluidic technologies have the potential to establish wide-spread utilization of the platform. This paper presents an in-depth review of the centrifugal microfluidic platform, while highlighting recent progress in the field and outlining the potential for future applications. An overview of centrifugal microfluidic technologies is presented, including descriptions of advantages of the platform as a microfluidic handling system and the principles behind centrifugal fluidic manipulation. The paper also discusses a history of significant centrifugal microfluidic platform developments with an explanation of the evolution of the platform as it pertains to academia and industry. Lastly, we review the few centrifugal microfluidic-based sample-to-answer analysis systems shown to date and examine the challenges to be tackled before the centrifugal platform can be more broadly accepted as a new diagnostic platform. In particular, fully integrated, easy to operate, inexpensive and accurate microfluidic tools in the area of <I>in vitro</I> nucleic acid diagnostics are discussed.</P> <P>Graphic Abstract</P><P>This paper presents an in-depth review of the centrifugal microfluidic platform for biomedical applications, while highlighting recent progress in the field and outlining the potential for future applications. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b924109d'> </P>
Flow-enhanced electrochemical immunosensors on centrifugal microfluidic platforms.
Kim, Tae-Hyeong,Abi-Samra, Kameel,Sunkara, Vijaya,Park, Dong-Kyu,Amasia, Mary,Kim, Nahui,Kim, Jintae,Kim, Hanshin,Madou, Marc,Cho, Yoon-Kyoung Royal Society of Chemistry 2013 Lab on a chip Vol.13 No.18
<P>We present a novel fully integrated centrifugal microfluidic device with features for target antigen capture from biological samples, via a bead-based enzyme-linked immune-sorbent assay, and flow-enhanced electrochemical detection. The limit of detection (LOD) of our device for the C-reactive protein (CRP) was determined to be 4.9 pg mL(-1), a 17-fold improvement over quantification by optical density. The complete sample-to-answer protocol of our device is fully automated and takes less than 20 min. Overall, the presented microfluidic disc adds to the comparatively small number of fully integrated microfluidic-based platforms that utilize electrochemical detection and exemplifies how electrochemical detection can be enhanced by flow to successfully detect very low levels of biomarkers (e.g. pg mL(-1)).</P>