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Anti-proliferative, anti-inflammatory and antioxidant effects of curcumin analogue A2
Zhi-Yun Du,Xingchuan Wei,Mou-Tuan Huang,Xi Zheng,Yue Liu,Allan H. Conney,Kun Zhang 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.10
In the present study, we determined the antiproliferative,anti-inflammatory and antioxidant effects of acurcumin analogue, 2,6-bis(3,4-dihydroxybenzylidene) cyclohexanone(designated as A2). In vitro studies showed that A2had a stronger inhibitory effect on the growth of mousemacrophage RAW 264.7 cells than curcumin. A2 also showeda stronger inhibitory effect than curcumin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases inNF-jB activation and IL-1b expression as well as in aldosereductase activity. A2 was a stronger antioxidant than curcuminas determined by inhibition of lipid peroxidation,inhibition of 1,1-diphenyl-2-picryl-hydrazyl free radical formation,and inhibition of 2,20-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical formation. In vivo studiesindicated that A2 was more potent than curcumin for inhibitingTPA-induced ear edema and TPA-induced increases inIL-1b. In addition, oral administration of A2 at a dose of2,000 mg/kg body weight did not cause acute toxicity inmice. Taken together, the results of our study indicate that thecurcumin analogue A2 has stronger anti-proliferative, antiinflammatoryand antioxidant activities than curcumin.
Wang, Hua-Qian,Li, Dong-Li,Lu, Yu-Jing,Cui, Xiao-Xing,Zhou, Xiao-Fen,Lin, Wei-Ping,Conney, Allan H.,Zhang, Kun,Du, Zhi-Yun,Zheng, Xi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21
Acanthopanax trifoliatus (L) Merr (AT) is commonly used as an herbal medicine and edible plant in some areas of China and other Asian countries. AT is thought to have anticancer effects, but potential mechanisms remain unknown. To assess the anticancer properties of AT, we exposed prostate cancer cells to AT extracts and assessed cell proliferation and signaling pathways. An ethanol extract of AT was suspended in water followed by sequential extraction with petroleum ether, ethyl acetate and n-butanol. PC-3 cells were treated with different concentrations of each extract and cell viability was determined by the MTT and trypan blue exclusion assays. The ethyl acetate extract of the ethanol extract had a stronger inhibitory effect on growth and a stronger stimulatory effect on apoptosis than any of the other extracts. Mechanistic studies demonstrated that the ethyl acetate extract suppressed the transcriptional activity of NF-${\kappa}B$, increased the level of caspase-3, and decreased the levels of phospho-Erk1/2 and phospho-Akt. This is the first report on the anticancer activity of AT in cultured human prostate cancer cells. The results suggest that AT can provide a plant-based medicine for the treatment or prevention of prostate cancer.
Huaqian Wang,Dongli Li,Zhi-Yun Du,Mou-Tuan Huang,Xiaoxing Cui,Yujing Lu,Chenyue Li,Swee Lian Woo,Allan H Conney,Xi Zheng,Kun Zhang 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.3
Stems and leaves of Acanthopanax trifoliatus (L) Merr (AT) are commonly used as an edible vegetable in China. The scientific basis of antioxidant and antiinflammatory activities of AT was investigated. The polyphenol contents and free radical scavenging activities of AT ethanol extracts (EAT) were determined. Chlorogenic acid, isochlorogenic acid A, isochlorogenic acid C, and rutin were identified as major components in EAT. LPS-induced NO production in RAW264.7 cells was decreased significantly (p<0.05) after EAT treatment, compared with controls. In vivo studies indicated that EAT had more activity than chlorogenic acid per mg of dry weight for inhibition of TPA-induced ear edema. TPA-induced increases in cytokine production (TNF-α, IL-6, MMP-9, and TIMP-1) were significantly (p<0.05) reduced by EAT treatment, compared with controls. EAT exerts anti-inflammatory activities probably due, at least in part, to chlorogenic acid.