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- 저자 : Ali Fadaei (검색결과 2 건)
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A Novel Real-time Fuzzy Adaptive Auto-Tuning Scheme for Cascade PID Controllers
Ali Fadaei,Karim Salahshoor 제어·로봇·시스템학회 2011 International Journal of Control, Automation, and Vol.9 No.5
This paper presents a novel fuzzy auto-tuning methodology to continuously adapt PID control actions without interrupting the normal process operation. New auto-tuning rules are introduced to schedule a gradual and guided activation of each individual P, I and D control mode in three adjustable functional control zones. An auto-scaling procedure has been incorporated to generalize the auto-tuning scheme to efficiently respond to any set-point change outside a pre-defined operating span. In contrast to existing auto-tuning algorithms, the proposed scheme is not an on-demand auto-tuning methodology and hence does not require alertness of an experienced engineer to initiate and supervise its initial operation in a separate commissioning identification pre-test. This interesting feature provides a new perspective on PID auto-tuning approaches. Performance of the proposed auto-tuning scheme is practically evaluated in a real pilot plant within a networked control system (NCS) configuration, realized by industrial Ethernet and Foundation Fieldbus technologies. An extensive series of test scenarios has been conducted to explore efficiency of the proposed auto-tuning methodology to cope with fixed and varying operating set-points under uncertain and variable network transmission time delays and external disturbance.
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Ali Dehshahri,Samira Hossaini Alhashemi,Akram Jamshidzadeh,Zahra Sabahi,Soliman Mohammadi Samani,Hossein Sadeghpour,Erfaneh Mohazabieh,Mahin Fadaei 한국고분자학회 2013 Macromolecular Research Vol.21 No.12
Interleukin-12 (IL-12) has been proposed for cancer immunotherapy due to its versatile antitumor and antiangiogenesis effects. Although cancer immunotherapy through systemic administration of IL-12 has shown antitumor effects in tumor-bearing mice, broad application of recombinant IL-12 protein has been limited by its cytotoxicity. Therefore, the use of various polycationic polymers such as polyethylenimine (PEI), polyamidoamine (PAMAM) and chitosan has been considered as an effective strategy to transfer plasmid encoding IL-12 gene into cells. In this investigation, polyplexes (polymer/pDNA complexes) were prepared using PEI, PAMAM and chitosan at different N/P ratios and their ability in transferring plasmid encoding IL-12 gene was evaluated. Furthermore,these polyplexes were characterized and compared with regarding their cytotoxicity, DNA condensation ability, particle size, zeta potential, buffering capacity and pDNA protection against enzyme degradation. The results revealed that the polyplexes formulated with 25 kDa PEI and chitosan had the highest transfection efficiencies. The highest level of IL-12 gene expression was achieved by the nanoparticles prepared by 25 kDa PEI where they could increase the level of gene expression up to 12 times compared to that of naked plasmid encoding IL-12 gene. These results suggest that 25 kDa PEI and chitosan are the best candidates for adding targeting ligands into their structures in order to create a liver targeting gene delivery system.
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