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      저자 : Ali Atashabparvar (검색결과 1 건)
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        Additional cytogenetic aberrations in chronic myeloid leukemia: a single-center experience in the Middle East

        Akbar Safaei,Ahmad Monabati,Moeinadin Safavi,Ali Atashabparvar,Marzieh Hosseini 대한혈액학회 2018 Blood Research Vol.53 No.1

        BackgroundAdditional cytogenetic aberrations are associated with disease progression in chronicmyeloid leukemia (CML). This study was conducted to determine the type and frequencyof these aberrations and their relationship with hematologic and molecular findings inthe Middle East. MethodsIn this retrospective study, 134 well-established cases of CML were selected from 2010to 2016. Their hematologic phase and type of fusion gene were determined. Finally, theirkaryotypes were analyzed and reported according to ISCN 2013. ResultsPatients had a mean age of 44 years. Twenty-two patients (16.4%) showed additional cytogeneticaberrations. Nine patients (6.7%) harbored a variant Philadelphia chromosome,and most were in the chronic phase. Seventeen patients (12.7%) had major and minorroute abnormalities. There was a significant relationship between additional cytogeneticaberrations and major molecular response (P=0.032). Patient survival in the group withadditional cytogenetic aberrations was significantly lower (49.7±11.1 mo) than that inthe group without additional cytogenetic aberrations (77.3±3.1 mo) (P=0.031). ConclusionThis study revealed the same frequency of additional cytogenetic aberrations in CML asfound in previous studies. Additional chromosomal aberrations led to shorter survivaland lower rates of achievement of a major molecular response.

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