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Measurements of B→J/ψ at forward rapidity in p+p collisions at s=510 GeV
Aidala, C.,Ajitanand, N. N.,Akiba, Y.,Akimoto, R.,Alexander, J.,Alfred, M.,Aoki, K.,Apadula, N.,Asano, H.,Atomssa, E. T.,Attila, A.,Awes, T. C.,Ayuso, C.,Azmoun, B.,Babintsev, V.,Bai, M.,Bai, X.,Banni American Physical Society 2017 Physical Review D Vol.95 No.9
<P>We report the first measurement of the fraction of J/psi mesons coming from B-meson decay (F (B -> J/psi)) in p + p collisions at root s = 510 GeV. The measurement is performed using the forward silicon vertex detector and central vertex detector at PHENIX, which provide precise tracking and distance-of-closest-approach determinations, enabling the statistical separation of J=. due to B-meson decays from prompt J/psi. The measured value of F (B -> J/psi) is 8.1% +/- 2.3% (stat) +/- 1.9% (syst) for J/psi with transverse momenta 0 < p(T) < 5 GeV/c and rapidity 1.2 < vertical bar y vertical bar < 2.2. The measured fraction F (B -> J/psi) at PHENIX is compared to values measured by other experiments at higher center of mass energies and to fixed-order-next-toleading- logarithm and color-evaporation-model predictions. The b (b) over bar cross section per unit rapidity [d sigma/dy(pp -> b (b) over bar)] extracted from the obtained F (B -> J/psi) and the PHENIX inclusive J/psi cross section measured at 200 GeV scaled with color-evaporation-model calculations, at the mean B hadron rapidity y = +/- 1.7 in 510 GeV p + p collisions, is 3.63(-1.70)(+1.92) mu b. It is consistent with the fixed-order-next-toleading- logarithm calculations.</P>
PHENIX Collaboration,Afanasiev, S.,Aidala, C.,Ajitanand, N.N.,Akiba, Y.,Alexander, J.,Al-Jamel, A.,Aoki, K.,Aphecetche, L.,Armendariz, R.,Aronson, S.H.,Averbeck, R.,Awes, T.C.,Azmoun, B.,Babintsev, V. North-Holland Pub. Co 2009 Physics letters: B Vol.679 No.4
We present the first measurement of photoproduction of J/ψ and of two-photon production of high-mass e<SUP>+</SUP>e<SUP>-</SUP> pairs in electromagnetic (or ultra-peripheral) nucleus-nucleus interactions, using Au+Au data at s<SUB>NN</SUB>=200 GeV. The events are tagged with forward neutrons emitted following Coulomb excitation of one or both Au<SUP>@</SUP>? nuclei. The event sample consists of 28 events with m<SUB>e<</SUB>SUP><SUB><</SUB>/SUP>+<SUB>e<</SUB>SUP><SUB><</SUB>/SUP>->2 GeV/c<SUP>2</SUP> with zero like-sign background. The measured cross sections at midrapidity of dσ/dy(J/ψ+Xn,y=0)=76+/-33(stat)+/-11(syst) μb and d<SUP>2</SUP>σ/dmdy(e<SUP>+</SUP>e<SUP>-</SUP>+Xn,y=0)=86+/-23(stat)+/-16(syst) μb/(GeV/c<SUP>2</SUP>) for m<SUB>e<</SUB>SUP><SUB><</SUB>/SUP>+<SUB>e<</SUB>SUP><SUB><</SUB>/SUP>-@?[2.0,2.8] GeV/c<SUP>2</SUP> have been compared and found to be consistent with models for photoproduction of J/ψ and QED based calculations of two-photon production of e<SUP>+</SUP>e<SUP>-</SUP> pairs.
ForwardJ/ψproduction in U + U collisions at<sub>sNN</sub>=193GeV
Adare, A.,Aidala, C.,Ajitanand, N. N.,Akiba, Y.,Akimoto, R.,Alexander, J.,Alfred, M.,Aoki, K.,Apadula, N.,Asano, H.,Atomssa, E. T.,Awes, T. C.,Azmoun, B.,Babintsev, V.,Bai, M.,Bai, X.,Bandara, N. S.,B American Physical Society 2016 Physical Review C Vol.93 No.3
<P>The invariant yields, dN/dy, for J/psi production at forward rapidity (1.2 < vertical bar y vertical bar < 2.2) in U + U collisions at root S-NN = 193 GeV have been measured as a function of collision centrality. The invariant yields and nuclear-modification factor R-AA are presented and compared with those from Au + Au collisions in the same rapidity range. Additionally, the direct ratio of the invariant yields from U + U and Au + Au collisions within the same centrality class is presented, and used to investigate the role of c (c) over bar coalescence. Two different parametrizations of the deformed Woods-Saxon distribution were used in Glauber calculations to determine the values of the number of nucleon-nucleon collisions in each centrality class, N-coll, and these were found to give significantly different Ncoll values. Results using N-coll values from both deformed Woods-Saxon distributions are presented. The measured ratios show that the J/psi suppression, relative to binary collision scaling, is similar in U + U and Au + Au for peripheral and midcentral collisions, but that J/psi show less suppression for the most central U + U collisions. The results are consistent with a picture in which, for central collisions, increase in the J/psi yield due to c (c) over bar coalescence becomes more important than the decrease in yield due to increased energy density. For midcentral collisions, the conclusions about the balance between c (c) over bar coalescence and suppression depend on which deformed Woods-Saxon distribution is used to determine N-coll.</P>
Jörg U. Schmohl,Martin Felices,Felix Oh,Alexander J. Lenvik,Aaron M. Lebeau,Jayanth Panyam,Jeffrey S. Miller,Daniel A. Vallera 대한암학회 2017 Cancer Research and Treatment Vol.49 No.4
Purpose The selective elimination of cancer stem cells (CSCs) in tumor patients is a crucial goal because CSCs cause drug refractory relapse. To improve the current conventional bispecific immune-engager platform, a 16133 bispecific natural killer (NK) cell engager (BiKE), consisting of scFvs binding FcRIII (CD16) on NK cells and CD133 on carcinoma cells, was first synthesized and a modified interleukin (IL)-15 crosslinker capable of stimulating NK effector cells was introduced. Materials and Methods DNA shuffling and ligation techniques were used to assemble and synthesize the 1615133 trispecific NK cell engager (TriKE). The construct was tested for its specificity using flow cytometry, cytotoxic determinations using chromium release assays, and lytic degranulation. IL-15–mediated expansion was measured using flow-based proliferation assays. The level of interferon (IFN)- release was measured because of its importance in the anti-cancer response. Results 1615133 TriKE induced NK cell–mediated cytotoxicity and NK expansion far greater than that achieved with BiKE devoid of IL-15. The drug binding and induction of cytotoxic degranulation was CD133+ specific and the anti-cancer activity was improved by integrating the IL-15 cross linker. The NK cell–related cytokine release measured by IFN- detection was higher than that of BiKE. NK cytokine release studies showed that although the IFN- levels were elevated, they did not approach the levels achieved with IL-12/IL-18, indicating that release was not at the supraphysiologic level. Conclusion 1615133 TriKE enhances the NK cell anti-cancer activity and provides a self-sustaining mechanism via IL-15 signaling. By improving the NK cell performance, the new TriKE represents a highly active drug against drug refractory relapse mediated by CSCs.
Christoph-Alexander J. von Klot,Axel S. Merseburger,Alena Böker,Sebastian Schmuck,Tobias L. Ross,Frank M. Bengel,Markus A. Kuczyk,Christoph Henkenberens,Hans Christiansen,Hans-Jürgen Wester,Wiebke Sol 대한핵의학회 2017 핵의학 분자영상 Vol.51 No.4
Purpose 68Ga-labeled prostate-specific membrane antigen (PSMA) ligand positron emission tomography/computed tomography (PET/CT) has shown promising results in patients with biochemical recurrence after primary therapy for prostate cancer. In this study, we evaluated the usefulness of PSMA I&T (imaging and therapy) PET/CT prior to radical prostatectomy. Methods The study population consisted of 21 patients with prostate cancer who underwent 68Ga-PSMA I&T PET/CT before either open or laparoscopic radical prostatectomy. Intraprostatic tumor extent, extracapsular extension (ECE) and seminal vesicle invasion (SVI) were assessed on the PET/CT scans. Tracer uptake was quantified in terms of standardized uptake values (SUVs). Imaging findings were correlated with final whole-gland histopathology. Results Of the 21 patients, two had T stage 2b disease, nine stage 2c, six stage 3a and four stage 3b. The median Gleason score was 7. The SUVmean of the primary tumors was 9.5 ± 8.8. SUVmean was higher in tumors with ECE than in organconfined tumors (13.8 ± 11.0 vs. 5.6 ± 3.2, p = 0.029). Peak tracer uptake was significantly positively correlated with Gleason score (rs = 0.49, p = 0.025). Sensitivity, specificity, positive predictive value and negative predictive value were, respectively, 94.7%, 75.0%, 97.3% and 60.0% for tumor infiltration of an individual prostate lobe, 75.0%, 100.0%, 100.0% and 97.4% for SVI, and 90.0%, 90.9%, 90.0% and 90.9% for ECE, using an angulated contour of the prostate as the criterion. Tumor volume derived from 68Ga-PSMA I&T PET/CT was significantly correlated with preoperative prostate-specific antigen value (rp = 0.75, p < 0.001) and tumor volume on histopathology (rp = 0.45, p = 0.039). Conclusions 68Ga-PSMA I&T PET/CT prior to radical prostatectomy can contribute to presurgical local staging of prostate cancer. In this pilot study, 68Ga-PSMA I&T PET/CT showed promising results for prediction of lobe infiltration, ECE and SVI.
Graphene as interface modifier in ITO and ITO-Cr electrodes
Leticia A. Silva,Jéssica M.M. Luzardo,Sanair M. Oliveira,Rafael V. Curti,Alexander M. Silva,Rogerio Valaski,Rodrigo B. Capaz,Joyce R. Araujo 한국물리학회 2020 Current Applied Physics Vol.20 No.7
We explore graphene as interface modifier for electrodes in optoelectronic organic devices by measuring the electrical properties of ITO/graphene and ITO/Cr/graphene. For this purpose, exfoliated graphene (EG) was electrochemically synthesized and deposited by spray-pyrolysis. The built-in voltage (Vbi) values were 450 mV for the ITO/CuPc/Al reference, 750 mV for ITO/Cr/graphene/CuPc/Al and 1000 mV for ITO/graphene/CuPc/Al device structures. From these results, we estimate the work functions as 3.20 eV, 3.45 eV and 4.75 eV for ITO/ EG, ITO/Cr/EG and ITO. To understand how the work function changes, we carried out first-principles calculations based on density-functional theory (DFT) where Cr work function (~4.2 eV) is not modified by the deposition of pristine graphene; however there is a substantial increase (from 4.2 eV to 5.2 eV), upon deposition of graphene oxide (GO), resulting from a complete transfer of O atoms from the GO sheet to the Cr surface forming a thin layer of chromium oxide.
Phospholipid dynamics in ex vivo lung cancer and normal lung explants
Lesko Julia,Triebl Alexander,Stacher-Priehse Elvira,Fink-Neuböck Nicole,Lindenmann Jörg,Smolle-Jüttner Freyja-Maria,Köfeler Harald C.,Hrzenjak Andelko,Olschewski Horst,Leithner Katharina 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
In cancer cells, metabolic pathways are reprogrammed to promote cell proliferation and growth. While the rewiring of central biosynthetic pathways is being extensively studied, the dynamics of phospholipids in cancer cells are still poorly understood. In our study, we sought to evaluate de novo biosynthesis of glycerophospholipids (GPLs) in ex vivo lung cancer explants and corresponding normal lung tissue from six patients by utilizing a stable isotopic labeling approach. Incorporation of fully 13 C-labeled glucose into the backbone of phosphatidylethanolamine (PE), phosphatidylcholine (PC), and phosphatidylinositol (PI) was analyzed by liquid chromatography/mass spectrometry. Lung cancer tissue showed significantly elevated isotopic enrichment within the glycerol backbone of PE, normalized to its incorporation into PI, compared to that in normal lung tissue; however, the size of the PE pool normalized to the size of the PI pool was smaller in tumor tissue. These findings indicate enhanced PE turnover in lung cancer tissue. Elevated biosynthesis of PE in lung cancer tissue was supported by enhanced expression of the PE biosynthesis genes ETNK2 and EPT1 and decreased expression of the PC and PI biosynthesis genes CHPT1 and CDS2 , respectively, in different subtypes of lung cancer in publicly available datasets. Our study demonstrates that incorporation of glucose-derived carbons into the glycerol backbone of GPLs can be monitored to study phospholipid dynamics in tumor explants and shows that PE turnover is elevated in lung cancer tissue compared to normal lung tissue.
Mechanical Eye Model for Evaluating Intraocular Pressure Measurements
Kutaiba Saleh,Volkmar Unger,Alexander Dietzel,Detlef Heydenreich,Rico Großjohann,Clemens Jürgens,Frank Tost,Jens Haueisen 대한의용생체공학회 2014 Biomedical Engineering Letters (BMEL) Vol.4 No.4
Purpose For the development of new intraocular pressure(IOP) measurement devices, as well as for comparison withexisting devices it is important to consider the variousbiomechanical properties of the eye in test setups. Therefore,a controllable physical phantom with flexibility in theadjustment of biomechanical parameters and geometries isbeing proposed and analyzed. Methods Different configurations of a mechanical eyemodel are simulated together with the applanation process,based on the finite element method (FEM). Forming toolsare designed to produce artificial corneas with variablethicknesses and stiffness’s using injection molding. Anapparatus is assembled for controlling and evaluating thephantom eye in connection with a piezoelectric IOP testsensor. Measurements are also performed using thecommercially available non-contact tonometer NCT-800. Results Simulation results for surface pressure and stressdistribution at the cornea together with the pressure in thecentral part of the applanation body show that the pressurereaches a maximum when the local stress is centrallyconcentrated and decreases to a stable level afterwards. Morerigid corneas result in higher maximum values for thepressure. The measurements with the piezoelectric IOP testsensor are in good agreement with the simulation results. The NCT-800 measurements show a significant influence of the biomechanical properties of the cornea on measured IOPs. Conclusion Our phantom is suitable for describing the effectof biomechanical characteristics of the human eye ontonometric measurements and will facilitate the evaluation ofnew tonometry systems.