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Erman, Fazilet,Aydin, Suleyman,Demir, Yasar,Akcay, Fatih,Bakan, Ebubekir Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.5
Modifications in dietary fatty acid intake might lead to a modification in membrane phospholipid fatty acid composition. The purpose of this study was to investigate relationship between different type of oil consumption and leukocyte membrane phospholipid composition. This study was carried out in subjects utilizing butter (n = 15), margarine (n = 15), fluid oil (n = 15) and mixed types of oils (n = 15) in total 60 subjects. Leukocytes were separated from total blood by dextran sedimentation method. Membrane lipids and proteins were isolated following the cell disruption. Fatty acids of membrane phospholipids were isolated by hydrolysation with phospholipase B under ultrasonic dismembranator. Free fatty acids were identified with gas chromatography at chloroform phase. The results obtained were compared with data obtained by chromatograms of the standards. Results more prominent values of arachidic, dihomo-$\gamma$-linolenic and palmitoleic acids were found in butter-or mixed oil-user groups; eicosadienoic, eicosamonoenoic, dihomo-$\gamma$-linolenic and behenic acids in fluid oil; heptanoic, valeric, eicosadienoic and linolenic acids in margarine groups. The fatty acid composition of mixed oil was similar to butter, while other two oils were so different. From this study, it was concluded that the type of oil consumption might have an influence on phospholipid components of plasma membranes.
Ismail Demiryilmaz,Ebru Sener,Nihal Cetin,Durdu Altuner,Fatih Akcay,Halis Suleyman 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.9
In this study, the biochemical and histopathologicaleffects of thiamine and thiamine pyrophosphate onischemia–reperfusion induced oxidative damage in ratovarian tissue were investigated. Animals were divided intofour groups of six rat each, ovarian ischemia–reperfusion(IR), 25 mg/kg thiamine ? ovarian ischemia–reperfusion(TIR), 25 mg/kg thiamine pyrophosphate ? ovarian ischemia–reperfusion (TPIR) and Sham group (SG). The resultsof the biochemical experiments have shown that the ratovarian tissue with thiamine treatment, the level of MDA,GSH and the 8-hydroxyguanine are almost the same as theIR group; while in the group with thiamine pyrophosphatetreatment, the level of MDA, GSH and the 8-hydroxyguanineare almost the same as the SG. Ovarian tissue of rats inthe IR group were congested and dilated vessels, edema,hemorrhage, necrotic and apoptotic cells. In this group, themigration and the adhesion of the polymorphonuclear leucocytesto the endothelium were observed. Both ovaries inTPIR group, there was no difference according to the SG. Histopathology of ovarian tissues in the TIR group wasalmost the same with the IR group. Our results indicate thatthiamine pyrophosphate significantly prevents the ischemia–reperfusion induced oxidative damage in ovarian tissue,whereas thiamine has no effect. In conclusion, we havefound that thiamine pyrophosphate prevents oxidativedamage due to ischemia–reperfusion injury, whereasthiamine does not have this effect. Furthermore, we haveconfirmed that the results of our biochemical analyses are inconcordance with the histopathological findings.
Effects of Epinephrine and Cortisol on the Analgesic Activity of Metyrosine in Rats
Yavuz Albayrak,Mustafa Bahadir Saglam,Kadir Yildirim,Saliha Karatay,Beyzagul Polat,Turan Uslu,Fatih Akcay,Halis Suleyman 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.9
Some endogenous hormones (epinephrine and cortisol) can change an individual’s pain threshold. Propranolol is a non-selective β adrenergic receptor blocker which antagonises the antiinflammatory effect of non-steroidal anti-inflammatory drugs via the β1 and β2 adrenergic receptors. The roles of epinephrine and cortisol were investigated in the analgesic activity of metyrosine in rats with reduced epinephrine levels induced by metyrosine. Pain threshold measurement was performed using an analgesimeter with different doses and the single or combined usage of metyrosine, prednisolone, metyrapone and propranolol in rats. Epinephrine and corticosterone levels were measured by high-performance liquid chromatography in metyrosine-administered rats. Metyrosine reduces the epinephrine levels without affecting the corticosterone levels, thereby creating an analgesic effect. It was determined that prednisolone did not have an analgesic effect in rats with normal epinephrine levels, but its analgesic activity increased with a parallel decrease in the epinephrine levels. Similarly, the combined use of prednisolone and metyrosine provided a stronger analgesic effect than that rendered by metyrosine alone. The strongest analgesic effect, however, was observed in the group of rats with the lowest epinephrine level in whom the metyrosine + prednisolone combination was administered. The findings of this study may be useful in severe pain cases in which the available analgesics are unable to relieve the individual’s pain.