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RISS 인기검색어
- 검색키워드
- 저자 : Akash Mehta (검색결과 5 건)
- 무료
- 기관 내 무료
- 유료
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Bhardwaj, Neha,Bhardwaj, Sanjeev,Mehta, Jyotsana,Kim, Ki-Hyun,Deep, Akash Elsevier 2016 Biosensors & bioelectronics Vol.86 No.-
<P><B>Abstract</B></P> <P>The sensitive detection of dipicolinic acid (DPA) is strongly associated with the sensing of bacterial organisms in food and many types of environmental samples. To date, the demand for a sensitive detection method for bacterial toxicity has increased remarkably. Herein, we investigated the DPA detection potential of a water-dispersible terbium-metal organic framework (Tb-MOF) based on the fluorescence quenching mechanism. The Tb-MOF showed a highly sensitive ability to detect DPA at a limit of detection of 0.04nM (linear range of detection: 1nM to 5µM) and also offered enhanced selectivity from other commonly associated organic molecules. The present study provides a basis for the application of Tb-MOF for direct, convenient, highly sensitive, and specific detection of DPA in the actual samples.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Dipicolinic acid (DPA) is an excellent indicator of bacterial infection. </LI> <LI> In this work, metal organic frameworks (MOFs) are explored as potential DPA detectors. </LI> <LI> Fluorescent detection of DPA is achieved by synthesizing the Tb-MOF ‘Tb(BTC)(H<SUB>2</SUB>O)<SUB>6</SUB>’. </LI> </UL> </P>
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Bhardwaj, Neha,Bhardwaj, Sanjeev K.,Mehta, Jyotsana,Kim, Ki-Hyun,Deep, Akash American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.39
<P>To produce a sensitive and specific biosensor for Staphylococcus aureus, bacteriophages have been interfaced with a water-dispersible and environmentally stable metal-organic framework (MOF), NH2-MIL-53(Fe). The conjugation of the MOF with bacteriophages has been achieved through the use of glutaraldehyde as cross-linker. Highly sensitive detection of S. aureus in both synthetic and real samples was realized by the proposed MOF-bacteriophage' biosensor based on the photoluminescence quenching phenomena; limit of detection (31 CFU/mL) and range of detection (40 to 4 X 10(8) CFU/mL). This is the first report exploiting the use of an MOF-bacteriophage complex for the biosensing of S. aureus. The results of our study highlight that-the proposed biosensor is more sensitive than most of the previous methods while exhibiting some advanced features like specificity) regenerability, extended range of linear 'detection, and stability for long-term storage (even at room temperature).</P>
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Bhardwaj, Sanjeev K.,Bhardwaj, Neha,Kaur, Rajnish,Mehta, Jyotsana,Sharma, Amit L.,Kim, Ki-Hyun,Deep, Akash The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.31
<P>Metal-organic frameworks (MOFs) are known to possess many interesting material properties such as high specific surface area, tailorable porosity, adsorption/absorption capabilities, post-synthetic modifications, and chemical/thermal stabilities. Because of these unique features, they have been explored for the development of sensors for a variety of analytes. A large proportion of pre-existing MOF-based sensors are well suited for optical transductions due to a lack of electrical conduction in their pristine forms. Hence, the development of MOF-based electrochemical/electrical sensors requires specialized strategies through which MOFs are modified or hybridized with enhanced conductive moieties (<I>e.g.</I>, <I>via</I> doping or post synthetic modification). In this review article, we provide a comprehensive review of various synthetic and integrating strategies to improve electrical conductivity and long-range charge transport properties in MOFs. To this end, we have compiled details of different techniques that have been used to develop electrically/electrochemically active platforms for MOF-based sensing of various targets.</P>
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Use of GammaPlan convolution algorithm for dose calculation on CT and cone-beam CT images
Prabhakar Ramachandran,Ben Perrett,Orrie Dancewicz,Venkatakrishnan Seshadri,Catherine Jones,Akash Mehta,Matthew Foote 대한방사선종양학회 2021 Radiation Oncology Journal Vol.39 No.2
Purpose: The aim of this study was to assess the suitability of using cone-beam computed tomography images (CBCTs) produced in a Leksell Gamma Knife (LGK) Icon system to generate electron density information for the convolution algorithm in Leksell GammaPlan (LGP) Treatment Planning System (TPS). Materials and Methods: A retrospective set of 30 LGK treatment plans generated for patients with multiple metastases was selected in this study. Both CBCTs and fan-beam CTs were used to provide electron density data for the convolution algorithm. Plan quality metrics such as coverage, selectivity, gradient index, and beam-on time were used to assess the changes introduced by convolution using CBCT (convCBCT) and planning CT (convCT) data compared to the homogeneous TMR10 algorithm. Results: The mean beam-on time for TMR10 and convCBCT was found to be 18.9 ± 5.8 minutes and 21.7 ± 6.6 minutes, respectively. The absolute mean difference between TMR10 and convCBCT for coverage, selectivity, and gradient index were 0.001, 0.02, and 0.0002, respectively. The calculated beam-on times for convCBCT were higher than the time calculated for convCT treatment plans. This is attributed to the considerable variation in Hounsfield values (HU) dependent on the position within the field of view. Conclusion: The artifacts from the CBCT’s limited field-of-view and considerable HU variation need to be taken into account before considering the use of convolution algorithm for dose calculation on CBCT image datasets, and electron data derived from the onboard CBCT should be used with caution.
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Fluorescent nanobiosensors for the targeted detection of foodborne bacteria
Bhardwaj, Neha,Bhardwaj, Sanjeev K.,Nayak, Manoj K.,Mehta, Jyotsana,Kim, Ki-Hyun,Deep, Akash Elsevier 2017 Trends in analytical chemistry Vol.97 No.-
<P>Foodborne diseases caused by bacterial pathogens are severe threats to human health. Conventional culture based microbiologic methods for the analysis of bacterial contamination in food products are laborious, time consuming and require specific skills. Immunologic and polymerase chain reaction (PCR) based molecular methods are also costly, lack specificity, and may yield false results. As outlined in this review, fluorescent nanobiosensors have now become effective alternative tools for rapid and routine detection of foodborne bacteria. We provide an overview of the use of different fluorescent nano materials in the development of nanobiosensors with special emphasis on underlying detection principles, sensitivity, specificity, and their capability of multiplexed analysis. In summary, the diverse nanomaterials used for bacterial detection are critically analyzed with respect to their advantages and limitations for future applications in the diagnosis of foodborne bacteria. (C) 2017 Elsevier B.V. All rights reserved.</P>
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