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Factors Associated with the Timeliness of Electronic Nursing Documentation
Meejung Ahn,최모나,YoungAh Kim 대한의료정보학회 2016 Healthcare Informatics Research Vol.22 No.4
Objectives: To investigate the factors associated with the timeliness of electronic nursing documentation using the entry time on the Electronic Medical Record (EMR) system. Methods: As a retrospective study, data were extracted from January 1 to February 28, 2014 from a hospital EMR system and a nurses’ personnel information system. The timeliness of instances of nursing documentation was categorized into ‘timely’ or ‘untimely’ according to whether the entry time was time-stamped within the working hours during each day, evening, or night shift. Factors associated with the timeliness of the electronic nursing documentation were included in the logistic regression models as nurse- and patient-associated factors. Results: Among 1,700,247 instances of electronic nursing documentation, 79.3% (n = 1,347,711) were completed within the working hours. Years of nursing experience, nursing shift, days of the week, patients’ age, and medical department had a statistically significant associated with the timeliness of nursing records. Nurses with experience of more than 1 year entered nursing records over 2 times more during their working hours than did less experienced nurses. During the evening and night shifts, nurses were 1.49 times and 9.19 times more likely to enter nursing documents in a timely manner, respectively, as compared to those in the day shift. Conclusions: Nursing documentation was typically completed outside of working hours when a nurse had little experience, worked during the day shift or weekdays, and when tasks were unpredictable. This shows that new nurses need support to familiarize them with various tasks and the overall workflow.
Ahn, Meejung,Min, Do Sik,Kang, Jongchul,Jung, Kyungsook,Shin, Taekyun 제주대학교 생명과학기술혁신센터 2002 제주생명과학연구 Vol.5 No.-
Phospholipase D1 (PLD1) expression was studied in the central nervous system (CNS) under the condition of induced experimental autoimmune encephalomyelitis (EAE) in Lewis rats. After inducing EAE, the expression of PLD1 was analyzed by Western blot and immunohistochemistry. Western blot analysis showed that expression of the isozymes PLD1 significantly increased in the spinal cord at the peak stage of EAE, and declined thereafter. Immunohistochemistry showed that PLD1 positive cells increased in number in EAE lesions, which consisted mainly of ED1 positive macro phages and glial fibrillary acidic protein positive astrocytes. In contrast, PLD1 was only weakly expressed in some spinal cord astrocytes in control rats. These results suggest that PLD1 is increased in autoimmune CNS inflammation, and possibly involved in the activation of macrophages and astrocytes in EAE lesions. ⓒ 2001 Elsevier Science Ireland Ltd, All rights reserved.
Ahn, Meejung,Kang, Jongchul,Lee, Yongduk,Riu, Keyzung,Kim, Yong-sik,Jee, Youngheun,Matsumoto, Yoh,Shin, Taekyun 제주대학교 방사능이용연구소 2001 연구보고 Vol.15 No.-
자기면역성 뇌척수염(experimental autoimmune encephalomyelitis, EAE)은 뇌조직항원을 면역한 후 야기되는 염증성 질병으로 사람 다발성결화증의 한 모델로 연구되고 있다. 자기면역성 뇌염의 시작은 뇌조직항원에 반응하는 림프구가 중추신경계에 침윤되면서 마비를 나타내는데 이 과정 중에는 여러 종류의 pro-inflammatory mediator (tumor necrosis factor-alpha (TNF-α)와 inducible nitric oxide synthase (iNOS)등)가 관여하는 것으로 알려지고 있다. 이 연구에서는 염증의 진행 단계에 따라 염증 유도 또는 염증 억제의 상반된 기능을 갖는 것으로 알려진 TNF-α와 iNOS가 심급성 뇌척수염 진행에 어떠한 영향을 미치는지를 조사하였다. 뇌염을 유도하기 위한 항원으로는 랫트 척수 조직 유제를 complete Freund adjuvant와 혼합하여 뒷 발바닥에 주사하였으며 심한 뇌척수염을 유도하기 위하여 pertussis toxin(500ng/ea)을 면역하는 날 복강내로 주사하고 매일 체중과 마비 정도를 확인하였다. 독소를 주사한 실험군에서는 대조군(11일)에 비해 마비의 시작이 빨랐으며(9일), 대조군은 자연 회복하는 반면 독소룰 주사한 실험군에서는 모두 폐사하였다. 척수 조직 내 TNF-α 와 iNOS의 양적인 변화를 조사하기 위하여 Competitive PCR과 Western blot를 이용하였으며, 세포형을 구분하기 위하여 면역염색을 이용하였다. Competitive PCR결과 TNF-α는 PT를 투여한 자기면역성뇌척수염의 심한 마비기(EAE,G3)에서 PT를 투여하지 않은 대조군보다 약 5배가 증가하였으며(p<0.01), Western blot결과 iNOS는 PT를 투여한 군에서 정상조직에 비해 약 6배가 증가하였고, PT를 투여하지 않은 군에 비해서는 약 3개바 증가하였다(p<0.01). 면역염색결과 PT를 투여하지 않은 랫트보다 투여한 랫트의 척수조직에서 iNOS 양성 세포가 약 15배가 증가하였으며(p<0.01), 또한 연속절편에서 이들 세포가 큰포식세포임을 확인하였다. 이상의 결과를 종합해 볼 때, 자기면역성 뇌척수염의 초기 유도과정에서는 TNF-α와 iNOS는 염증의 약화에 관여됨을 알 수 있었다. The involvement of inducible nitric oxide synthase (iNOS) and tumor necrosis factor alpha (TNF-α), which have diverse roles in the progression of autoimmune disease models, was studied in pertussis toxin (PT-induced hyperacute experimental autoimmune encephalomyelitis (EAE) in Lewis rats. The expression of TNF-α mRNA(increased 5 fold, p<0.01) and iNOS protein (3 fold, p<0.01) was much greater in the spinal cords with PT(+) EAE at the peak stage of EAE than in those with PT(-) EAE, as shown by competitive PCR and Western blot analysis, respectively. Immunohistochemistry showed that the majority of EDI-positive macrophages in EAE lesions contained iNOS, and that three were many more iNOS-positive cells in the CNS lesions of PT(+) rats than in those of PT(-) rats. These findings suggest that PT-induced hyperacute EAE is partly mediated by the enhanced expression of iNOS and TNF-α in the early stages of rat EAE.
Ahn, Meejung,Moon, Jihwan,Park, Changnam,Bang, Hyojin,Kim, Gi Ok,Kim, Sun-Ju,Kim, Ki-heung,Shin, Taekyun Kyung Hee Oriental Medicine Research Center, Kyung 2016 Oriental Pharmacy and Experimental Medicine Vol.16 No.1
We evaluated whether crude juice extract of chungpihongsim radish (Raphanus sativus L. cv. Chungpihongsim) (CH radish), with its characteristic red flesh and white skin, ameliorated ethanol-induced gastric injury in rats. Animals were divided into five groups: normal control, a group given CH radish extract (1000 mg/kg) only, two groups orally administered CH radish extract (500 and 1000 mg/kg, respectively, daily for 2 weeks) with ethanol treatment (5 mL/kg) 24 h after final administration of CH radish extract, and a group treated with ethanol alone. Tissues of stomach were collected after sacrifice, and the gastric mucosal injury index using hemorrhagic lesions were measured. Lipid peroxidation was evaluated based on malondialdehyde concentration. The radical-scavenging enzymes superoxide dismutase (SOD) and catalase (CAT) were also measured. Rats treated with CH radish extract (500 or 1000 mg/kg) for 2 weeks experienced no change in body weight. Pretreatment with the extract at both doses significantly ameliorated ethanol-induced hemorrhagic lesions in the gastric mucosa (p< 0.05), decreased malondialdehyde concentration (p< 0.05), and increased the levels of SOD (p< 0.05) and CAT (p< 0.05), compared to ethanol-alone treatment. These findings suggest that pretreatment with CH radish extract reduces ethanol-induced damage in the gastric mucosa, mediated partly by a decrease in lipid peroxidation and an increase in the cytoprotective radical-scavenging enzymes SOD and CAT.
Meejung Ahn,Poornima D. E. Weerasinghe-Mud,Hyobin Kim,Minju Kwon,Jeongtae Kim,Taekyun Shin 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Progranulin (PGRN) which is a secreted neurotrophin mediates cell cycle progression and cell motility that contribute to MHC-mediated antigen processing, pathogen removal, and autoimmunity. To evaluate the involvement of PGRN in experimental autoimmune neuritis (EAN) pathogenesis, as a model of human demyelinating diseases such as Guillain- Barré Syndrome. The expression of PGRN in rat sciatic nerves with EAN was studied. PGRN expression was increased significantly in EAN-affected sciatic nerves compared with normal rat sciatic nerves. The elevated levels of PGRN in the sciatic nerves of rats with EAN at the peak stage and then its expression was decreased significant at the recovery stage. The cellular phenotype of PGRN in EAN lesions consisted mainly of inflammatory cells including macrophages and Schwann cells whereas it was expressed constitutively in axons. Collectively, this study suggests that PGRN secreted by a variety of cells including macrophage, vascular endothelial cells and Schwann cells, plays either pro-inflammatory or tissue regenerative effects, or both depending on PGRN containing cell type, during the course of EAN, an animal model of human demyelinating disease. (Acknowledgement: This work was supported by the National Research Foundation of Korea: Grant number NRF-2017R1A2B4012478)