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Byoung Ok Ahn,Dong Hwan Kim,Hyeon Cho,Kyung Koo Kang,Beom Soo Park,Kyu Heum Na,Soo Hyung Kang,Won Bae Kim 한국독성학회 1999 Toxicological Research Vol.15 No.2
Toxic effects of recombinant human basic fibroblast growth factor (bFGF) were investigated in Sprague-Dawley rats by repeated subcutaneous administration. Four groups of 10 male and 10 female rats were treated with bFGF at doses of 0 (control), 40, 200, or 1000 ㎍/kg/day for 4 weeks. Additional 5 male and 5 female rats were used in control and high dose group to evaluate the reversibility of any treatment-related adverse effects. During the study, all rats survived until the end of the study. Noteworthy signs of toxicity at 200 ㎍/kg and above were swelling and subcutaneous cyst formation at the injection site. There were no remarkable changes in body weight, food and water consumption, ophthalmoscopy and urinalysis attributed to the bFGF treatment. Hematological examination showed increase in numbers of WBC and platelet, and decrease in RBC counts, hemoglobin concentration and hematocrit values at 200 and 1000 ㎍/kg groups with a dose-relation. In male rats from high dose group, a significant reduction of serum albumin was noted during the treatment and recovery period, which was thought to be due to edematous change of the injection site, at least in part. Absolute and relative liver weights increased in both sexes from high dose group. At necropsy, swelling and cyst formation at the injection site and splenomegaly were observed in high dose group and in some animals of middle dose group in a dose-related manner. Histopathological alterations were confined to the injection site and spleen. Proliferation of the capillaries and fibroblasts, focal hemorrhage and inflammatory cellular infiltration at the injection site, and congestion, megakaryocytic proliferation and the expansion of red pulp in the spleen were seen in bFGF-treated animals, which were more predominant in 1000 ㎍/kg group. At the end of the treatment, serum anti-bFGF IgG titer was elevated in all bFGF-treated rats in a dose-dependentfashion, indicating the test material, recombinant human bFGF (rh-bFGF), is the foreign protein to the rat to induce antibody formation. Most of treatment-related changes described above were thought to be associated with the pharmacological action of bFGF and were attenuated and disappeared after recovery phase. From the results, the target organs of bFGF when given to rats s.c. at doses up to 1000 ㎍/kg/day for 4 weeks were injection sites, blood cells, serum albumin and the spleen. Under the current test condition, the no-effect level of 40 ㎍/kg/day can be reported for both the male and female rats.
AHN, GOOK JUN,YU, JAE YOUNG,CHOI, SEUL MIN,KANG, KYUNG KOO,AHN, BYOUNG OK,KWON, JONG WON,KANG, SUNG KEUN,LEE, BYEONG CHUN,HWANG, WOO SUK Blackwell Science Ltd 2005 International journal of andrology Vol.28 No.5
<P>Summary</P><P>This study was conducted to determine if the long-term administration of the phosphodiesterase type 5 (PDE 5) inhibitor, DA-8159, to diabetic rats can ameliorate the development of erectile dysfunction (ED) and endothelial dysfunction. After inducing diabetes with streptozotocin, DA-8159 was orally administered at a dose of 3 mg/kg or 10 mg/kg for 8 weeks. To examine the effect on erectile response, electrostimulation of the cavernous nerve with the parameters of 3 V, 5 ms, 5 Hz or 10 Hz, was performed to measure the intracavernous pressure (ICP) and mean arterial pressure (MAP). Thoracic aorta relaxation <I>in vitro</I> was evaluated by adding acetycholine (Ach) cumulatively to the bathing medium. In addition, the plasma endothelin-1 (ET-1) levels were measured in order to investigate the effect of DA-8159 on endothelial dysfunction. The area under the curve (AUC) from the ICP/MAP ratio in the 10 Hz stimulation showed a significantly increased AUC after the 10 mg/kg treatment compared with the diabetic group (8891 ± 619 vs. 6316 ± 1016, respectively, <I>p</I> < 0.05). At the 5 Hz frequency, DA-8159 10 mg/kg also induced a significant increase in the AUC compared with the diabetic control. The maximum ICP/MAP ratio (%) of the 10 mg/kg treatment group was significantly higher in both the 10 Hz and 5 Hz frequency groups (<I>p</I> < 0.05). A treatment of 3 mg/kg tended to increase the AUC and peak ICP/MAP but was not statistically significant. The Ach EC<SUB>50</SUB> value of the diabetic group was significantly higher than in the normal control (120.50 ± 22.90 n<SMALL>M</SMALL> vs. 86.80 ± 9.30 n<SMALL>M</SMALL>, respectively), and 10 mg/kg treatment group showed a significantly lower EC<SUB>50</SUB> value (88.38 ± 19.7 n<SMALL>M</SMALL>). The ET-1 level was lower in groups treated with DA-8159, 3 mg/kg and 10 mg/kg treatment induced a statistical difference compared with the diabetic control (1.15 ± 0.34 fmol/mL vs. 2.51 ± 0.55 fmol/mL, respectively, <I>p</I> < 0.05). These results demonstrate that chronic administration of DA-8159 could attenuate the development of the ED in diabetes and its effect is associated with an improvement in the endothelial function.</P>
Byoung Ok Ahn(安炳玉),Seok Dong Kim(金石東),Hee Woon Park(朴喜運),Jang Hwan Park(朴長煥),Kwang Ho Kim(金光鎬) 한국육종학회 1994 한국육종학회지 Vol.26 No.4
Interspecific crosses between three peanut cultivars(Arachis hypogaea) having different plant type, and four wild species, Arachis monticola, Arachis correntina, Arachis applisippla, Arachis rigonii were made by gibberellin(GA₃) treatment and the GA₃ effect on the interspecific crossability and growth of pollen tube in pistil was investigated. Pollen germination on the stigma and penetration of the pollen tubes into the style were increased by GA₃ treatment on the flower base. The GA₃ treatment increased pegging and pod formation up to 47% and 1.6% higher than those of control, respectively. Interspecific-crossability was varied with the combination of cultivar and wild species. Combination of Shipung-type variety Daekwangtangkong×wild species and Spanish-type variety Jinpungtangkong×wild species showed about 2% higher crossability than those of Virginia type variety Namdaetangkong×wild species. Arachis monticola among wild species showed the highest crossability with peanut cultivars, while Arachis correntina did the lowest. This result suggested that interspecific crossbility become higher in the cross between autoplyploids rather than those between allopolyploids.
A Collaborative Study on Korean Standard JE Vaccine for Potency Assay
( Jae Ok Kim ),( Jin Ho Shin ),( Sun Young Baek ),( Kyung Il Min ),( Bok Soon Min ),( Seung Rel Ryu ),( Byoung Guk Kim ),( Do Keun Kim ),( Mi Jin Ahn ),( Mi Kyung Park ),( Hye Won Song ),( Chung Keel 한국미생물생명공학회 2004 Journal of microbiology and biotechnology Vol.14 No.4
Ryu, Byoung-Kweon,Ahn, Byoung-Ok,Oh, Tae-Young,Kim, Soon-Hoe,Kim, Won-Bae,Lee, Eun-Bang The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.5
The hepatoprotective effect of DA-9601, a quality-controlled extract of artemisisa asiatica, on liver damage induced by acetaminophen (APAP) and carbon tetrachloride ($CCI_{4}$) was investigated by means of serum-biochemical, hepatic-biochemical, and histopathological examinations. Doses of Da-9601 (10, 30, or 100 mg/kg) were administered intragastrically to each rat on three consecutive days i.e. 48 h, 24 h and 2 h before a single administration of APAP (640 mg/kg, i.p.) or $CCI_{4}$ (2 ml/kg, p.o.). Four h and 24 h after hepatotoxin treatment, the animals were sacrificed for evaluation of liver damage. Pretreatment of Da-9601 reduced the elevation of serum ALT, AST. LDH and histopathological changes such as centrilobular necrosis, vacuolar degeneration and inflammatory cell infiltration dose-dependently. Da-9601 also prevented APAP- and $CCI_{4}$-induced hepatic glutathione (GSH) depletion and $CCI_{4}$-induced increase of hepatic malondialdehyde (MDA), a parameter of lipid peroxidation, in a chemically induced liver injury by complex mechanisms which involve prevention of lipid peroxidation and preservation of hepatic GSH.
애엽추출물 항궤양제 DA-9601 의 랫드에 대한 4 주 경구 반복투여 독성연구
김옥진(Ok Jin Kim),강경구(Kyung Koo Kang),김동환(Dong Hwan Kim),백남기(Nam Gi Baik),안병옥(Byoung Ok Ahn),김원배(Won Bae Kim),양중익(Junn Ick Yang) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.4
This study was conducted to investigate the repeated dose toxicity of DA-9601, an antiulcer agent of Artemisia spp. extract, in rats. DA-9601 was administered orally once a day for 4 weeks to 10 males and 10 females per group at doses of 0(vehicle control), 125, 500 or 2000 mg/kg/day. Throughout the study, no treatment-related deaths and clinical signs were observed. In female rats receiving 125 mg/kg of DA-9601, water consumption increased slightly on day 4, 11 and 25. Hematological examination showed a decrease of MCV and an increase of PLT in male rats at the doses of 500 and 2000 mg/kg groups. Blood biochemistry revealed slight decreases of cholesterol, BUN and Na in male rats and decreases of total bilirubin and creatinine and slight increases of globulin and Cl in female rats. The organ weights at the end of 4 weeks showed slight changes in some organs of treated groups. But, all these changes were not considered to be of toxicological importance, because they did not show dose-response relationship and relevance to gross and microscopic findings. Histopathologically, abnormal treatment-related changes were not observed in any organ and target organs were not detected. On the basis of these results, the NOAEL(no-observed-adverse-effect level) of DA-9601 was estimated to be more than 2000 mg/kg/day under the conditions tested.
동물 및 기타 ArcGIS를 이용한 육상 및 해양 생태지도 3D제작
이병관 ( Byoung Kwan Lee ),이창래 ( Chang Rae Lee ),정원옥 ( Won Ok Jeong ),정승진 ( Seung Jin Jeong ),안중관 ( Jung Kwan Ahn ),김병국 ( Byeong Kuk Kim ),이홍헌 ( Heung Heon Lee ),박홍기 ( Hong Ki Park ),정주학 ( Joo Hak Jeong 한국환경생태학회 2013 한국환경생태학회 학술대회지 Vol.2013 No.2
해상국립공원지역의 생태계 기반 관리체계를 만드는데 도움이 되기 위해서 국립공원 연구 1호(국립공원관리공단, 147 ton)를 이용하여 한려해상국립공원과 다도해해상국립공원의 유·무인도서 및 특정도서에 대해서 육상조사, 수중조사와 해저지형을 조사하여 육상 및 해상, 해중을 연계한 종합생태지도를 제작하였다. 해중생태지도 제작을 위해서 육상 및 해상 좌표계를 통일하였으며, 조사 격자 범위에서 생태지도의 주요 생물상 분포를 분석한 다음에 ArcGIS 프로그램을 이용하여 생태지도를 제작하였다. 수치표고모형(DEM, Digital Elevation Model)을 작성하기 위해서 고도와 수심자료를 이용하여 불규칙삼각망(TIN)을 작성하고 육상 등고선과 해양 등수심선에 대해서 각각의 TIN을 만들어DEM을 작성 후, 지형을 분석하였다. 위성 및 항공영상의 배경합성은 육상과 해상의 고도와 수심 자료로 만든 DEM의 항공사진과 해저면 스캔영상을 따로 모자이크하고 합성하였다. 해저지형 분석은 ArcScene을 실행한 후, 따로 만든항공 및 해저 이미지에 DEM을 기저고도(Base Height)로 설정한 다음, 지형 분석에 이용하였다. 제작된 3차원 이미지는 0.25m격자의 해상도를 갖고 있는 항공영상과 해저면의Side Scan Sonar 이미지를 이용하였으며, 육상과 해양을 통합하여 3 차원 구현이 되도록 수행하였다. 촬영된 항공영상과 해저면 영상에 대해서 현장 검증을 수행하기 위해서육상 현장조사과 식생조사, 수중조사와 해양생물 분석 자료를 반영하여 해저와 육상 지형 분포도를 작성하였다. 본조사 결과를 이용하여 작성된 육상 및 해양 생태지도는 서식지와 생태계의 종합적인 관리지도를 작성하는 기초단계로서 기후변화와 생물다양성을 고려한 종합적인 관리지도로 발전시키고 향후, 외적인 환경변화를 추가함으로서 해양자원관리와 생물보전 방안을 마련하는데 활용해야 될 것이다.