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Ahmad Shabanizadeh,Shiva Roshankhah,Amir Abdolmaleki,Mohammad Reza Salahshoor 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.3
Solanum melongena green calyx (SMGC) with antioxidant features seems to have many therapeutic features. Diabetes mellitus (DM) is a blood sugar disorder that increases oxidative stress levels in various types of cells leading to testopathy. In this study we aimed to investigate the protective functions of hydro-alcoholic extract of SMGC on DM‐induced testicular damages. Mature male rats were randomly divided into five groups (n = 8); 1: control, 2: diabetic, 3: diabetic + 100 mg/kg of SMGC, 4: diabetic + 300 mg/kg of SMGC, and 5: diabetic + 500 mg/kg of SMGC. Intraperitoneal injection of streptozotocin (STZ, a single dose of 60 mg/kg) was used for DM induction. Testicular alterations were evaluated quantitatively based on stereological techniques and followed by antioxidant enzymes determination (catalase, superoxide dismutase, and glutathione peroxidase), and serum testosterone level. Malondialdehyde and Bcl‐2 protein expression were also assessed biochemically. DM caused significant harmful changes in testicular structure, inhibition of antioxidant enzymes activity, decreased testosterone levels, and increased lipid peroxidation (LP). The expression of Bcl‐2 protein was down-regulated in DM testis along with boosted apoptosis rate. Eight weeks of SMGC treatment (particularly in high doses) recovered structural variations significantly, restored the power of the antioxidant defense system, and modified the testosterone levels. These findings revealed that the SMGC is considered as an effective antioxidant agent to decrease the adverse effects of DM on male reproductive system.
Darehdori, Ahmad Shabanizadeh,Dastjerdi, Mehdi Nikbakht,Dahim, Hajar,Slahshoor, Mohammadreza,Babazadeh, Zahra,Taghavi, Mohammad Mohsen,Taghipour, Zahra,Gaafarineveh, Hamidreza Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
Objective: Promoter methylation, which can be regulated by MTHFR activity, is associated with silencing of genes. In this study we evaluated the methylation status (type) of the BRCA2 promoter in ovarian cancer patients carrying different genotypes of the MTHFR gene (A or C polymorphisms at position 1298). Methods: The methylation type of the BRCA2 promoter was evaluated using bisulfate-modified DNA in methylation-specific PCR and the MTHFRa1278c polymorphism was assessed by PCR-RFLP. Results: Analysis of the BRCA2 promoter methylation type of cases showed that 7 out of 60 cases (11.7%) were methylated while the remaining 53 (88.3%) were unmethylated. In methylated cases, one out of the 7 cases had a CC genotype and the remaining 6 methylated cases had an AC genotype. The AA genotype was absent. In unmethylated cases, 34, 18, and one out of these had AC, AA and CC genotype, respectively. Conclusion: There was no significant relationship between the methylation types of the BRCA2 promoter in different genotypes of MTHFRa1298c polymorphism in ovarian cancer; p=0.255. There was no significant relation between the methylation types of the BRCA2 promoter in different genotypes of the MTHFRa1298c polymorphism in ovarian cancer.