Family Origin Names and Haplotypes of Y - DNA in Korean Population

Kim, Jong Soon,Kim, Yung Jin,Ahn, Gwang Sook,Lee, Ju Won,You, Sun Ah 한국유전학회 1996 Genes & Genomics Vol.18 No.4

The use of restriction fragment length polymorphisms (RFLPs) has been proposed for the construction of a human genetic linkage map and also become a powerful tool in human population genetics. Human Y-chromosome which is haploid and paternally inherited is valuable for investigating male-mediated gene flow and for complement maternally based studies of mtDNA. We have studied 166 samples from 4 kinds of family origin names such as Kyungju Kim, Kimhae Kim, Chunju Lee and Milyang Park based on the 49aTaq 1 polymorphisms, and a total of 25 haplotypes were observed. The B, F, and I bands is observed in all haplotypes and haplotype showing A3, B, D2, D3, F, and I bands is common haplotype except for Chunju Lee. The result obtained are summarized as follows.

Biochemical Composition of Muscle from Tanaka's Eelpout Lycodes tanakae, Magistrate Armhook Squid Berryteuthis magister, and Ocean Sunfish Mola mola, Caught in the East Sea, Korea

Lee, Doo-Seog,Cho, Hyeon-Ah,Yoon, Na-Young,Kim, Yeon-Kye,Lim, Chi-Won,Shim, Kil-Bo The Korean Society of Fisheries and Aquatic Scienc 2012 Fisheries and Aquatic Sciences Vol.15 No.2

The biochemical composition of muscle from three deep-sea animals, Tanaka's eelpout Lycodes tanakae magistrate armhook squid Berryteuthis magister, and ocean sunfish Mola mola caught in the East sea in South Korea was determined. The moisture (81.4-93.8 g/100 g), crude protein (5.0-15.6 g/100 g), crude lipid (0.1-1.5 g/100 g), and ash (1.0-1.1 g/100 g) contents of the two fishes were analyzed. The proximate composition of magistrate armhook squid was: moisture 84.0 g/100 g, crude protein 12.4 g/100 g, crude lipid 0.7 g/100 g, and ash 1.5 g/100 g. There was little difference in the proximate compositions of the three animals. The total amino acid contents of Tanaka's eelpout, magistrate armhook squid, and ocean sunfish were 14.64, 10.75, 3.10-9.95 g/100 g, respectively. High levels of glutamic acid, aspartic acid, lysine, leucine, and arginine were found, while low levels of histidine, glycine, and cysteine were detected in the animals. A survey of the free amino acid contents of the animals revealed large amounts of alanine and glycine. Significant differences were found in the fatty acid composition among the three species. Specially, different saturated fatty acids (17.14-40.49%) such as C16:0, and C18:0, monounsaturated fatty acids (19.19-46.88%) such as C16:1, and C18:1, and polyunsaturated fatty acids (35.41-57.08%) such as EPA, and DHA was identified. Our results suggest that each of these deep sea animals possesses nutritional value and should be considered as a foodstuff.

Picrasma quassiodes (D. Don) Benn. attenuates lipopolysaccharide (LPS)-induced acute lung injury

Lee, Jae-Won,Park, Ji-Won,Shin, Na-Rae,Park, So-Yeon,Kwon, Ok-Kyoung,Park, Hyun Ah,Lim, Yourim,Ryu, Hyung Won,Yuk, Heung Joo,Kim, Jung Hee,Oh, Sei-Ryang,Ahn, Kyung-Seop Spandidos Publications 2016 International journal of molecular medicine Vol.38 No.3

<P>Picrasma quassiodes (D.Don) Benn. (PQ) is a medicinal herb belonging to the family Simaroubaceae and is used as a traditional herbal remedy for various diseases. In this study, we evaluated the effects of PQ on airway inflammation using a mouse model of lipopolysaccharide (LPS)-induced acute lung injury (ALI) and LPS-stimulated RAW 264.7 cells. ALI was induced in C57BL/6 mice by the intranasal administration of LPS, and PQ was administered orally 3 days prior to exposure to LPS. Treatment with PQ significantly attenuated the infiltration of inflammatory cells in the bronchoalveolar lavage fluid (BALF). PQ also decreased the production of reactive oxygen species (ROS) and pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in BALF. In addition, PQ inhibited airway inflammation by reducing the expression of inducible nitric oxide synthase (iNOS) and by increasing the expression of heme oxygenase-1 (HO-1) in the lungs. Furthermore, we demonstrated that PQ blocked the activation of mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappa B) in the lungs of mice with LPS-induced ALI. In the LPS-stimulated RAW 264.7 cells, PQ inhibited the release of pro-inflammatory cytokines and increased the mRNA expression of monocyte chemoattractant protein-1 (MCP-1). Treatment with PQ decreased the translocation of nuclear factor (NF)-kappa B to the nucleus, and increased the nuclear translocation of nuclear factor erythroid-2-related factor 2 (Nrf2) and the expression of HO-1. PQ also inhibited the activation of p38 in the LPS-stimulated RAW 264.7 cells. Taken together, our findings demonstrate that PQ exerts anti-inflammatory effects against LPS-induced ALI, and that these effects are associated with the modulation of iNOS, HO-1, NF-kappa B and MAPK signaling. Therefore, we suggest that PQ has therapeutic potential for use in the treatment of ALI.</P>

Identification of a New Cytotoxic Biflavanone from Selaginella doederleinii

LEE, Na-Youn,MIN, Hye-Young,LEE, Jun,NAM, Joo-Won,LEE, Yoo-Jin,HAN, Ah-Reum,Adam WIRYAWAN,Wahyu SUPRAPTO,LEE, Sang Kook,SEO, Eun-Kyoung 이화여자대학교 약학연구소 2009 藥學硏究論文集 Vol.- No.19

A new biflavanone, 2,2˝,3,3˝-tetrahydrorobustaflavone 7,4´,7˝-trimethyl ether (1) was isolated from the whole plant of Selaginella doederleinii H_(IERON). (Selaginellaceae) together with the known biflavonoid, robustaflavone 7,4´,7˝-trimethyl ether (2) as the cytotoxic constituents against the three human cancer cell lines, HCT, NCI-H358, and K562. The structure of the new compound 1 was elucidated by spectral analysis including various 1D- and 2D-NMR experiments.

A survey of the use of veterinary anesthetics in Korea

Lee, Jae-Won,Lee, Jeong Ik,Cho, Yoon Ju,Lee, Young-Ah,Kim, Jong-In,Hwang, Bo Ram,Kim, Hyung Joon,Jhun, Hyunjhung,Han, Jin Soo The Korean Society of Veterinary Science 2014 大韓獸醫學會誌 Vol.54 No.2

This study was conducted to investigate actual conditions associated with veterinary anesthetic drug use in Korea, and to obtain responses from Korean veterinarians and researchers pertaining to the use of anesthetic drugs. To accomplish this, a nationwide survey was issued to veterinarians working at animal hospitals and to researchers in the Korean Association for Laboratory Animal Science (KALAS). A self-administered questionnaire-based survey was then conducted in which respondents were asked questions about actual conditions associated with the use of animal anesthetic drugs. The survey revealed that the distribution and management of animal medicines in Korea was quite vulnerable to misuse or abuse due to a variety of factors. Therefore, a relevant regulatory system should be strictly enforced to protect vulnerable individuals from abuse or misuse.

Early detection of subclinical ventricular deterioration in aortic stenosis with cardiovascular magnetic resonance and echocardiography

Lee, Seung-Pyo,Park, Sung-Ji,Kim, Yong-Jin,Chang, Sung-A,Park, Eun-Ah,Kim, Hyung-Kwan,Lee, Whal,Lee, Sang-Chol,Park, Seung Woo,Sohn, Dae-Won,Choe, Yeon-Hyeon BioMed Central 2013 Journal of cardiovascular magnetic resonance Vol.15 No.-

<P><B>Background</B></P><P>Severe aortic stenosis (AS) patients with late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) or left ventricular (LV) systolic dysfunction are known to have worse outcome. We aimed to investigate whether LGE on CMR would be useful in early detection of subclinical LV structural and functional derangements in AS patients.</P><P><B>Methods</B></P><P>118 patients with moderate to severe AS were prospectively enrolled. Echocardiography and CMR images were taken and the patients were divided into groups according to the presence/absence of LGE and of LV systolic dysfunction (LV ejection fraction (EF) <50%). The stiffness of LV was calculated based on Doppler and CMR measurements.</P><P><B>Results</B></P><P>Patients were grouped into either group 1, no LGE and normal LVEF, group 2, LGE but normal LVEF and group 3, LGE with depressed LVEF. There was a significant trend towards increasing LV volumes, worsening of LV diastolic function (E/e’, diastolic elastance), systolic function (end-systolic elastance) and LV hypertrophy between the three groups, which coincided with worsening functional capacity (all p-value < 0.001 for trend). Also, significant differences in the above parameters were noted between group 1 and 2 (E/e’, 14.6 ± 4.3 (mean ± standard deviation) in group 1 vs. 18.2 ± 9.4 in group 2; end-systolic elastance, 3.24 ± 2.31 in group 1 vs. 2.38 ± 1.16 in group 2, all p-value < 0.05). The amount of myocardial fibrosis on CMR correlated with parameters of diastolic (diastolic elastance, Spearman’s ρ = 0.256, p-value = 0.005) and systolic function (end-systolic elastance, Spearman’s ρ = -0.359, p-value < 0.001).</P><P><B>Conclusions</B></P><P>These findings demonstrate the usefulness of CMR for early detection of subclinical LV structural and functional deterioration in AS patients.</P>

Study of Cu-X alloy seed layer on ITO for copper-plated silicon heterojunction solar cells

Lee, Sang Hee,Lee, Doo Won,Kim, Han Jun,Lee, Ah Reum,Lee, Soo Hong,Lim, Kyoung-jin,Shin, Won-suk Elsevier 2018 Materials science in semiconductor processing Vol.87 No.-

<P><B>Abstract</B></P> <P>For the reduction of optical loss and contact material cost in silicon heterojunction (SHJ) solar cells, copper plating has been considered as a suitable metallization technique. Usually, a metal seed layer is deposited on an indium tin oxide (ITO) prior to copper plating for adhesive contact between copper and ITO. As a requirement of suitable seed layer material, contact resistivity (ρ<SUB>c</SUB>) between the seed and the ITO is also important, as well as the adhesion, because high series resistance results in fill factor loss. In this study, we applied alloy seed layers which were deposited by co-evaporating copper with other metals (Cu-X). Contact resistivity values of the samples were extracted by using transfer length method (TLM). Also, tape tests were carried out to simply confirm the adhesion of contacts with different seed layers. Among the Cu-X alloy seed materials, the Cu-Ni alloy film resulted in good adhesion to the ITO as well as low average contact resistivity under 1 mΩ cm<SUP>2</SUP>.</P>

Korean parents' perceptions of the challenges and needs on school re-entry during or after childhood and adolescent cancer: a multi-institutional survey by Korean Society of Pediatric Hematology and Oncology

Lee, Jun Ah,Lee, Jae Min,Park, Hyeon Jin,Park, Meerim,Park, Byung Kiu,Ju, Hee Young,Kim, Ji Yoon,Park, Sang Kyu,Lee, Young Ho,Shim, Ye Jee,Kim, Heung Sik,Park, Kyung Duk,Lim, Yeon-Jung,Chueh, Hee Won The Korean Pediatric Society 2020 Clinical and Experimental Pediatrics (CEP) Vol.63 No.4

Background: For children and adolescents with cancer, going back to school is a key milestone in returning to "normal life." Purpose: To identify the support vital for a successful transition, we evaluated the parents' needs and the challenges they face when their children return to school. Methods: This multi-institutional study was conducted by the Korean Society of Pediatric Hematology and Oncology. The written survey comprised 24 questions and was completed by 210 parents without an interviewer. Results: Most parents (165 of 206) reported that their children experienced difficulties with physical status (n=60), peer relationships (n=30), academic performance (n=27), emotional/behavioral issues (n=11), and relationships with teachers (n=4) on reentering school. Parents wanted to be kept informed about and remain involved in their children's school lives and reported good parent-teacher communication (88 of 209, 42.1%). Parents reported that 83.1% and 44.9% of teachers and peers, respectively, displayed an adequate understanding of their children's condition. Most parents (197 of 208) answered that a special program is necessary to facilitate return to school after cancer therapy that offers emotional support (n=85), facilitates social adaptation (n=61), and provides tutoring to accelerate catch up (n=56), and continued health care by hospital outreach and school personnel (n=50). Conclusion: In addition to scholastic aptitude-oriented programs, emotional and psychosocial support is necessary for a successful return to school. Pediatric oncologists should actively improve oncology practices to better integrate individualized school plans and educate peers and teachers to improve health literacy to aid them in understanding the needs of children with cancer.

Therapeutic Exercise for Correction of Valgus Malaligned Knees: A Case Report

( Ah Ram Kim ),( Sang Hyup Song ),( Sang Won Seo ),( Hyun Sik Jeon ),( Ho Seong Lee ) 한국체육학회 2015 국제스포츠과학 학술대회 Vol.2015 No.1

Purpose: The lower limbs present varying valgus deformities that have a direct impact on the diversification of the load-bearing axis of the valgus limb, on the modification of gait kinematics. The purpose of this study was to determine the effect of therapeutic exercise on range of motion, lower limb alignment and standing anterior radiographs of hip and knee joint in a patient with valgus malaligned knees. Method: The subject of this case report was a 27-year-old male, who presented with knee joint valgus deformity. Therapeutic exercise program consisted patellar mobilization, knee joint distraction, side-lying bent knee hip abduction with external rotation, Side-lying hip abduction, prone hip extension with knee bent and strengthening the quadriceps muscle while squatting in hip adduction for 40min/day, twice a week, for 12-week. Physical characteristics (height, weight, BMI, % body fat, muscle mass), range of motion (hip flexion, extension, abduction, adduction, internal rotation, external rotation, knee flexion, extension), lower limb alignment test (Q-angle, rear foot alignment, leg length) and standing anterior-posterior (AP) radiographs of neck shaft angle and knee joint space of both lower limbs were measured before, after 6- and 12-week therapeutic exercise. Result: Following therapeutic exercise, increases in range of motion of hip flexion, extension, abduction, adduction, internal rotation and external rotation and decreases in Q-angle and leg length discrepancy were observed. Standing AP radiographs have been shown to improve neck shaft angle and knee joint space. Conclusion: These results of this case report suggest that therapeutic exercise improve valgus malalined knees.

Lactic Acid Bacteria Increase Antiallergic Effect of Artemisia princeps Pampanini SS-1

Lee, Seung-Hoon,Shin, Yong-Wook,Bae, Eun-Ah,Lee, Bo-Mi,Min, Sung-Won,Baek, Nam-In,Chung, Hae-Gon,Kim, Nam-Jae,Kim, Dong-Hyun The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.9

Artemisia princeps Pampanini, which is called Ssajuarissuk in Korean (SS-1), was fermented with lactic acid bacteria (LAB) and their passive cutaneous anaphylaxis reaction-inhibitory activity was investigated. Of these fermented agents, SS-1 extract fermented with Bifidobacterium infantis K-525 (F-SS-1) most effectively inhibited the release of ${\beta}$-hexosamindase from RBL-2H3 cells induced IgE. In IgE-induced RBL-2H3 cells, F-SS-1 inhibited proinflammatory cytokines IL-6 and $TNF-{\alpha}$ mRNA expression. Oral administration of SS-1 and F-SS-1 to mice inhibited passive cutaneous anaphylaxis (PCA) reaction induced by IgE and scratching behaviors induced by compound 48/80. The inhibitory activity of F-SS-1 against scratching behaviors was more effective than that of SS-1. These findings suggest that the fermentation of SS-1 with LAB can increase its antiallergic activity.