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      • SCIESCOPUSKCI등재

        Perilla frutescens var. japonica and rosmarinic acid improve amyloid-β<SUB>25-35</SUB> induced impairment of cognition and memory function

        Ah Young Lee,Bo Ra Hwang,Myoung Hee Lee,Sanghyun Lee,Eun Ju Cho 대한지역사회영양학회 2016 Nutrition Research and Practice Vol.10 No.3

        BACKGROUND/OBJECTIVES: The accumulation of amyloid-β (Aβ) in the brain is a hallmark of Alzheimer’s disease (AD) and plays a key role in cognitive dysfunction. Perilla frutescens var. japonica extract (PFE) and its major compound, rosmarinic acid (RA), have shown antioxidant and anti-inflammatory activities. We investigated whether administration of PFE and RA contributes to cognitive improvement in an Aβ25-35-injected mouse model. MATERIALS/METHODS: Male ICR mice were intracerebroventricularly injected with aggregated Aβ25-35 to induce AD. Aβ25-35-injected mice were fed PFE (50 mg/kg/day) or RA (0.25 mg/kg/day) for 14 days and examined for learning and memory ability through the T-maze, object recognition, and Morris water maze test. RESULTS: Our present study demonstrated that PFE and RA administration significantly enhanced cognition function and object discrimination, which were impaired by Aβ25-35, in the T-maze and object recognition tests, respectively. In addition, oral administration of PFE and RA decreased the time to reach the platform and increased the number of crossings over the removed platform when compared with the Aβ25-35-induced control group in the Morris water maze test. Furthermore, PFE and RA significantly decreased the levels of nitric oxide (NO) and malondialdehyde (MDA) in the brain, kidney, and liver. In particular, PFE markedly attenuated oxidative stress by inhibiting production of NO and MDA in the Aβ25-35-injected mouse brain. CONCLUSIONS: These results suggest that PFE and its active compound RA have beneficial effects on cognitive improvement and may help prevent AD induced by Aβ.

      • SCIESCOPUSKCI등재

        [Acquired amegakaryocytic thrombocytopenia after thymectomy in a case of pure red cell aplasia associated with thymoma.]

        Cho, Ah Ra,Cha, Young Joo,Kim, Hye Ryoun,Park, Eun Kyung,Cha, Eun Jong 대한진단검사의학회 2010 Annals of Laboratory Medicine Vol.30 No.3

        <P>The association of thymoma with pure red cell aplasia has been well documented, but amegakaryocytic thrombocytopenia is not a recognized paraneoplastic syndrome complicating thymoma. We report a case of thymoma-complicated pure red cell aplasia and amegakaryocytic thrombocytopenia in a 73-yr-old woman. Pure red cell aplasia was diagnosed seven months after the detection of thymoma. One year after the diagnosis of pure red cell aplasia and seven months after thymectomy, bone marrow aspiration and biopsy showed an absence of megakaryocytes, marked erythroid hypoplasia with normal myeloid series. A diagnosis of amegakaryocytic thrombocytopenia and pure red cell aplasia was made. Oral steroid maintenance therapy resulted in recovery of platelet count. She has still transfusion-dependant anemia but platelet and neutrophil counts had been maintained in normal range for more than five months, until the last follow-up. We think that autoreactive T cells may induce a clinical autoimmune response even after eradication of thymoma, and aplastic anemia as a late complication following thymectomy was described in previous cases. This patient also has to be under a close observation because of the possibility to evolve into aplastic anemia.</P>

      • KCI등재

        Identification of a p-Cresol Degradation Pathway by a GFP-Based Transposon in Pseudomonas and Its Dominant Expression in Colonies

        ( Ah Ra Cho ),( Eun Jin Lim ),( Yaligara Veeranagouda ),( Kyoung Lee ) 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.11

        In this study, the chromosome-encoded pcuRCAXB genes that are required for p-cresol degradation have been identified by using a newly constructed green fluorescent protein (GFP)-based promoter probe transposon in the long-chain alkylphenol degrader Pseudomonas alkylphenolia. The deduced amino acid sequences of the genes showed the highest identities at the levels of 65-93% compared with those in the databases. The transposon was identified to be inserted in the pcuA gene, with the promoterless gfp gene being under the control of the pcu catabolic gene promoter. The expression of GFP was positively induced by p-cresol and was about 10 times higher by cells grown on agar than those in liquid culture. In addition, phydroxybenzoic acid was detected during p-cresol degradation. These results indicate that P. alkylphenolia additionally possesses a protocatechuate ortho-cleavage route for pcresol degradation that is dominantly expressed in colonies.

      • Case Reports : Vaginal delivery in a spontaneously conceived singleton pregnancy complicated with hyperreactio Luteinalis: A case report

        ( Ah Ra Cho ),( Tae Bok Song ),( Hyun Jung Kim ),( Yoon Ha Kim ),( Jong Woon Kim ) 대한산부인과학회 2011 Journal of Womens Medicine Vol.4 No.2

        Hyperreactio luteinalis (HL) is characterized by bilaterally marked cystic enlargement of the ovaries containing multiple benign theca lutein cysts. HL is rarely observed during a spontaneously conceived normal singleton pregnancy. We present a case of a 29-year-old woman who was initially detected with markedly enlarged multicystic ovaries in the 9 weeks of a spontaneously conceived pregnancy. Ultrasonographic follow-up of the ovaries were done in order to avoid unnecessary exploratory laparotomy during pregnancy. At 40 weeks of gestation, a healthy female infant weighing 2,910 g was delivered vaginally. Since normal spontaneous remission occurs after delivery or during pregnancy in many cases, conservative management is appropriate rather than performing unnecessary intervention. We hereby report a rare case of HL managed non-surgically resulting in successful vaginal delivery.

      • KCI등재

        Bilateral Anterior Opercular Syndrome With Partial Kluver–Bucy Syndrome in a Stroke Patient: A Case Report

        Ah-Ra Cho,Young-Ho Lim,Sae-Hoon Chung,Eun-Hi Choi,Jong Youb Lim 대한재활의학회 2016 Annals of Rehabilitation Medicine Vol.40 No.3

        Bilateral anterior opercular syndrome and partial Kluver–Bucy syndrome are associated with bilateral middle cerebral artery lesions. The combination of these two syndromes has only been reported in a child with limbic encephalitis. In this case, a 44-year-old woman with bilateral middle cerebral artery infarction, which occurred 2 years prior, could walk independently. However, she showed automatic-voluntary dissociation and anarthria with preserved writing skills. She also presented hypersexuality, hypermetamorphosis, and memory disturbances. Here, we report a case of an adult stroke patient who suffered from bilateral anterior opercular syndrome accompanied by partial Kluver–Bucy syndrome.

      • KCI등재

        한국 중앙 일간지의 독자투고 특성 연구

        조아라(Ah Ra Cho),이건호(Gunho Lee) 한국언론정보학회 2011 한국언론정보학보 Vol.55 No.3

        본 연구는 한국의 주요 일간지가 오피니언 면을 만든 1990년대 후반부터 약 10년을 분석 기간으로 삼아, 조선일보ㆍ동아일보ㆍ한겨레 등 3개 중앙 일간지 독자투고의 내용, 투고자 특성, 피드백 기능 유무에 따른 독자투고의 특성을 분석했다. 그 결과, 우리나라 독자투고가 단순히 개인적인 불만이나 피해를 토로하는 공간에서 다양한 이슈에 대한 독자들의 의견이 표현되는 공간으로 변화하고 있음이 확인됐다. 비록 독자투고에서 거론되는 이슈가 아직 사회와 경제 등 전통적인 내용을 많이 다루기는 하지만 미디어ㆍ문화ㆍ스포츠 등의 영역으로까지 그 범위가 확대되고 있었다. 더불어 이 기간동안 투고자 중 전문가 및 사회단체 소속 독자들이 늘어나고, 특정 기사에 대한 반응을 명기함으로써 피드백 기능을 확실히 한 내용의 투고들이 증가하고 있었다. 이와 같은 변화는 여론 형성을 위한 공간으로써 독자투고의 질적 측면이 향상되고 있다는 해석을 가능하게 했다. 하지만 투고자의 거주 지역이 수도권에 크게 편중된 것으로 나타나, 독자투고란 운영방침 변화 등 다양한 지역 의견을 확보하기 위한 매체의 노력이 필요할 것으로 보인다. This study analyzed the contents of letters-to-the-editor and the characteristics of the letters’ writers, featured in three major newspapers, Chosun Ilbo, Dong-a Ilbo and Hankyoreh, in Korea from 1997 to 2009. Additionally, based on whether the letters contained the feedback function or not, it scrutinized the attributes of the letters-to-the-editor. The results indicated that the role of letters-to-the-editor has changed from a space for showing merely personal dissatisfactions or complaints into a space for expressing the reader’s opinions about various issues. The study also showed that the proportion of writers who have specialized jobs and are members of civic groups steadily increased. It seems to tell that the quality of the letters was improved accordingly, because they could give in-depth opinions about the matters in which the society were interested. The feedback function of the letters was also gradually more activated for those years, and it could be thought as another evidence supporting the quality improvement of the letters, which were supposed to form the healthful public opinion. However, the writers’ residential districts are heavily concentrated on the region surrounding Seoul, the capital of Korea. The study suggested that the newspapers should develop tools to overcome such defects.

      • KCI등재

        창원지역 초등학교 학생과 어머니의 김치에 대한 의식 및 섭취실태 조사

        조아라 ( Ah Ra Cho ),강옥주 ( Ok Ju Kang ),정효숙 ( Hyo Sook Cheong ) 대한영양사협회 2011 대한영양사협회 학술지 Vol.17 No.3

        This study aimed to examine consumers` interest, preference, and consumption frequency of Kimchi in elementary school students in the fifth grade and their mothers living in Changwon city. In a comparison of eating habits, students exhibited better eating habits than their mothers (P<0.01). Though the mothers` levels, were higher than those of the students in the category of ``eat foods with a bit of salt usually``, the students` levels were higher in the rest of the eating habit categories. The categories of ``like Kimchi``, ``spicy taste``, and ``appropriately spicy taste`` got high levels. Among several kinds of Kimchi, both students and mothers preferred ``cabbage Kimchi`` the most. Among various Kimchi foods, preferences for ``Kimchi pancake``, ``fried rice with Kimchi``, and ``tuna Kimchi soup``, were highest in that order. The preferences differed between students and mothers in each category; mothers` preferences were significantly higher than those of students. However, in the rest of categories, except ``boiled kimchi and fish`` and ``Kimchi and stir-fried spicy pork``, students` preferences were higher than mothers` ones. Compared to their preferences, students` consumption frequencies were significantly higher than mothers` ones (P<0.01). There were positive correlations among students` eating habits, awareness of Kimchi, consumption frequency, and preference. For mothers, there were positive correlations not only between eating habits and awareness, but also between awareness and preference.

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