Amino-Functionalized Mesoporous Silica Particles for Ocular Delivery of Brimonidine

Kim, Se-Na,Ko, Song Ah,Park, Chun Gwon,Lee, Seung Ho,Huh, Beom Kang,Park, Yoh Han,Kim, Young Kook,Ha, Ahnul,Park, Ki Ho,Choy, Young Bin American Chemical Society 2018 MOLECULAR PHARMACEUTICS Vol.15 No.8

<P>To treat glaucoma, conventional eye drops are often prescribed. However, the eye drops have limited effectiveness as a result of low drug bioavailability due to their rapid clearance from the preocular space. To resolve this, we proposed amino-functionalized mesoporous silica (AMS) particles as delivery carriers of the glaucoma drug, brimonidine. Because of the presence of mesopores, brimonidine (BMD) could be encapsulated in the AMS with a loading amount of 41.73 μg/mg (i.e., drug loading capacity of about 4.17%) to give the BMD-AMS, which could release the drug in a sustained manner over 8 h. BMD-AMS was also shown to be mucoadhesive due to the presence of both hydroxyl and amino groups in the surface, allowing for formation of hydrogen bonds and an ionic complex with the mucin, respectively. Therefore, when topically administered to rabbit eyes in vivo, BMD-AMS could reside in the preocular space for up to 12 h because of its adherence to the mucous layer. To assess in vivo efficacy, we examined the variance in intraocular pressure (IOP) and brimonidine concentration in the aqueous humor (AH) after applying BMD-AMS to the eye, which was compared with that induced by Alphagan P, the marketed brimonidine eye drops. For BMD-AMS, the duration in the decrease in IOP and the area under the drug concentration in the AH-time curve (AUC) were 12 h and 2.68 μg·h/mL, respectively, which were about twice as large as those obtained with Alphagan P; this finding indicated enhanced ocular bioavailability of brimonidine with BMD-AMS.</P> [FIG OMISSION]</BR>

개 비장 질환의 미세세침흡입술을 통한 세포병리학 검사 4례

김현아,윤기영,최호정,정성목,이영원,조성환,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2011 動物醫科學硏究誌 Vol.18 No.1

To evaluate the accuracy and diagnostic significance of cytopathological diagnosis of canine splenic disorders, cytopathological examination throgh fine-needle aspiration(FNA) referred to Veterinary Medical Teaching Hospital of Chungnam National University were retrospectived. Splenic neoplasm, hemolymphatic neoplasm, hyperplasia, extramedullary hematopoiesis and splenitis were diagnosed canine splenic disorders through cytopathological examination. The patient should be identified what coagulation profile are normal before aspiration, because complication such as hemorrhage could happen. The 4 cases were identified symmetric, asymmetric splenomegaly on abdominal ultrasonography and then were performed ultrasound-guided FNA. The 4 cases were diagnosed hemangiosarcoma(2), hyperplasia(1) and extramedullary hematopoiesis(1) by clinical signs, hematological examination, and cytopathological examination. Cytopathological examination through FNA was cost-effective, no gneral anesthesia, no complication, and non-invasive method of diagnosis for canine splenic disorders.

고양이의 만성 췌장염 치료 증례

김현아,윤기영,박정호,이왕희,송근호,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2011 動物醫科學硏究誌 Vol.18 No.1

A 5-year-old Russian blue cat was referred to the Veterinary Medical Teaching Hospital of Chungnam National University with the history of anorexia, lethargy, weight loss(6.5 to 4.8 kg) 2 weeks ago. Abdominal ultrasonography showed the following : increase of echogenicity of liver, irregular shape of gall bladder, hyperechoic region around duodenum. Pancreatitis, cholangitis, hepatic lipidosis was diagnosed by the ultrasonography. Anti- inflammatory therapy, antibiotic therapy was administered. Abdominal ultrasonography is a efficient available diagnostic tool but serum fPL test reveals the highest sensitivity and specifity result for feline pancreatitis. SNAP fPL test is newly released that can check pancreatitis within 10 minutes by same princple of Spec fPL test used in Gastrointestinal Laboratory of Texas A & M Univerrsity.

Ki-67 Expression Gives Additional Prognostic Information on St. Gallen 2007 and Adjuvant! Online Risk Categories in Early Breast Cancer

Jung, So-Youn,Han, Wonshik,Lee, Jong Won,Ko, Eunyoung,Kim, Eunkyu,Yu, Jong-Han,Moon, Hyeong-Gon,Park, In Ae,Oh, Do-Youn,Im, Seock-Ah,Kim, Tae-You,Hwang, Ki-Tae,Kim, Sung-Won,Noh, Dong-Young Springer - Society of Surgical Oncology 2009 Annals of Surgical Oncology Vol.16 No.5

동안신경 상분지만을 침범한 토로사-헌트 증후군 1예

성기범,이태경,박선아,안무영 대한평형의학회 2003 Research in Vestibular Science Vol.2 No.2

악안면 유형에 따른 측모 연조직 양상에 대한 연구

태기출,김상철,국윤아,권영택 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.5

본 연구의 목적은 악안면유형에 따라 측모 연조직 양상에 차이가 있는지를 알아보고자 17세 이상의 연령을 가진 다양한 수직적 양상을 보이는 Ⅱ급 및 Ⅲ급 남, 녀 79명을 선택하여 각 계측치를 계측하고 통계처리하여 다음과 같은 결과를 얻었다. 1. Nasolabial angle, interlabial angle, lower lip angle, mentolabial angle, symphyseal angle이 골격성 Ⅱ급군과 Ⅲ급군간에 유의한 차이를 보였고, nasofrontal angle, upper lip angle, mentolabial angle, symphyseal angle이 high angle군과 low angle군간에 유의한 차이를 보였다. 2. 악골의 시상적관계를 나타내는 ANB값이 연조직의 nasolabial angle, symphyseal angle, interlabial angle과 정상관 관계를 보였고, lower lip angle과는 역상관 관계를 보였다. 3. 악골의 수직적관계를 나타내는 SN-GoMe값은 연조직의 mentolabial angle, symphyseal angle, nasofrontal angle, upper lip angle과 정상관 관계를 보였다. 4. 골격성 Ⅲ급군에 비해 Ⅱ급군에서 SN-GoMe값에 따른 측모연조직 양상의 차이가 현저하였다. The purpose of this study was to investigate the variations of the soft tissue profile contour in relation to the skeletal patterns and to confirm the correlation of soft tissue angles to the sagittal or vertical skeletal elements. Lateral cephalograms of 79 cases which were older than 17 years in age, were traced and statistically analyzed The obtained results were as follows: 1. Nasolabial, interlabial, lower lip, mentolabial, and symphyseal angles showed the significant differences between skeletal ClassⅡ and skeletal. Class Ⅲ group, but nasofrontal, upper lip, mentolabial, and symphyseal angles showed the significant differences between high angle and low angle group. 2. ANB value showed the significant positive correlation to nasolabial, symphyseal, and interlabial angles and the significant negative relation to lower lip angle. 3. SN-GoMe value showed the significant positive correlation to mentolabial, symphyseal, nasofrontal, and upper lip angles. 4. Soft tissue profile contour in SK. ClassⅡ group showed greater accordance to SN-GoMe value than those in SK. class Ⅲ group.

브라켓 부착시 실런트 레진이 법랑질 탈회에 미치는 영향

윤영아,이기헌,황현식,홍석진 전남대학교 치의학연구소 2002 구강과학 Vol.14 No.1

The purpose of this study was to evaluate the effects of a sealant resin on enamel demineralization in orthodontic bracket bonding. The forty eight extracted sound bovine teeth was subdivided into four groups and treated with Phase Ⅱ^(r) on the surface. Group 1 was not treated, Group 2 was acid etched with 37% phosphoric acid for 30 seconds, Group 3 was sealant applied after acid etching and Group 4 was resin paste applied after acid etching and sealant application. Each group was demineralized in artificial caries solution. Demineralized enamel depth was measured using by confocal laser scanning microscopy. The results were as follows. 1. The mean demineralized enamel depth was Group 1 (47.4㎛), Group 2 (61.8㎛), Group 3 (13.9㎛), Group 4 (8.2㎛). 2. The demineralized enamel depth was increased in Group 2 than Group 1 (p<0.05). 3. The demineralized enamel depth was reduced in Group 3 than Group1 and Group 2 with statistically significant differences (p<0.05). 4. Group 4 was very little demineralized. The results of the present study indicate that sealant application is useful for reducting enamel demineralization in orthodontic bracket bonding.

TRANSPALATAL LINGUAL ARCH에 의한 골내 응력 분포에 관한 광탄성적 연구

고기영,태기출,국윤아,김상철 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.5

본 연구는 TMA wire로 제작된 transpalatal lingual arch에 의한 골내 응력 분포를 파악하기 위하여 양측성 및 편측성 확장을 가하여 이때 발생하는 치아주위조직 응력 분포 양상을 광탄성 응력해석법으로 관찰하여 다음과 같은 결과를 얻었다. 1. 양측성 확장시 수평 변형만 적용했을 때 탄선끝이 각진 경우 둥근 탄선끝을 적용한 경우보다 응력이 치근단으로 집중되며 회전중심을 의미하는 흑색선이 변화하는 양태를 보였고 수직변형량이 증가되면서 전체적인 응력차수의 증가와 흑색선의 하방 이동 양상을 보였다. 2. 편측성 확장을 위해 수평 변형과 함께 확장측에만 수직 변형을 적용하였을 때 확장력이 확장측으로 편중되는 응력분포를 관찰할 수 있었다. 수직 변형량의 증가시 확장측 구치는 정출하는 응력을 보였고 수평변형량의 증가시 고정측치아도 경사지려는 응력분포가 관찰하였다. 3. 편측 구치의 회전을 개선하기 위해 철사끝을 비대칭적으로 toe-in한 경우 변형량이 적은 구치의 치근단 원심측에 응력분포를 관찰할 수 있었다. 4. 악궁 확장시 철사의 길이를 줄일수록 무늬차수가 증가하는 응력 분포를 보였다. The purpose of this study was to investigate the stress distribution and intensity derived from the transpalatal lingual arch in the investing bone composed of photoelastic material(PL-3). The transpalatal lingual arch wire was deflected in the horizontal and vertical direction to give the various conditions. The two-dimensional photoelastic stress analysis was performed, and the stress distrebution was recored by photography. The results were as follows: 1. In bilateral expansion, as horizontal deflection was singly applied, the stress was more concentrated on the root apex in square free end than round. In square free end, as vertical deflection was increased gradually, the black line meaning center of rotation moved inferiorly together with the increment of whole fringes. 2. In application of vertical deflection on anchorage side for unilateral expansion, the stress distribution that expansive force leaned to expansion side was observed. As vertical deflection increased, the extruding stress was observed on molar of expansion side. And as horizontal deflection increased, the tipping stress on the molar of anchorage side was observed. 3. In unilateral rotation with the asymmetric toe-in, the fringe appeared on the distal aspect of root apex.

브라켓 부착 시 실런트 레진이 법랑질 탈회에 미치는 영향

윤영아,조진형,이기헌 대한치과교정학회 2005 대한치과교정학회지 Vol.35 No.1

본 연구는 교정용 브라켓 부착 시 사용되는 접착제 중 two paste type 의 실런트 레진 적용이 법랑질 탈회에 미치는 영향을 알아보고자 시행되었다. 건전한 표면을 가진 발치된 소의 상악절치 48개를 실험재료로 하여 법랑질 처리 방법에 따라 4개 군으로 분류하고 각 군을 Phase Ⅱ^(?) (Reliance, Itasca, Ⅲ) 를 이용하여 치면처리 하였다. 대조군으로서 아무런 처리를 하지 않은 Group 1, 37% 인산으로 39초간 산부식을 시행한 Group 2, 산부식 후 실런트 A와 B를 동량으로 혼합하여 도포한 Group 3과 산부식 후 실런트를 도포하고 레진 페이스트 A와 B를 동량으로 혼합하여 도포한 Group 4로 분류하여 각 군을 인공탈회용액에서 탈회시킨 다음 공초점 레이저 주사현미경을 이용하여 각각의 탈회된 깊이를 측정한 후 비교한 결과, 탈회된 법랑질의 평균 깊이는 47.4 ㎛ (Group 1), 61.8 ㎛ (Group 2), 13.9 ㎛ (Group 3), 8.2 ㎛ (Group 4) 로 나타났다. 산부식 후 인공탈회용액에 노출되는 군(Group 2)은 산부식 없이 노출되는 군 (Group 1) 에 비해 탈회된 깊이가 더 깊은 것으로 나타났으며 (p <0.55), 실런트 레진을 도포한 군 (Group 3) 은 산부식 없이 노출되는 군 (Group 1) 이나 산부식 후 노출되는 군 (Group 2) 에 비해 탈회된 법랑질 깊이가 유의성 있게 감소하였다 (p <0.55). 접착레진으로 부착된 군 (Group 4) 은 법랑질 탈회가 거의 나타나지 않았다. 이상의 연구결과는 교정지료 시 법랑질 탈회 가능성을 줄이기 위해서 브라켓 부착 시 실런트 레진의 도포가 유용함을 시사하였다. The purpose of this study was to evaluate the effects of a sealant resin on enamel demineralization in orthodontic bracket bonding. The forty eight extracted sound bovine teeth were subdivided into four groups and treated with Phase Ⅱ^(?) (Reliance, Itasca, Ⅲ) on the surface. Group 1 was not treated. Group 2 was acid etched with 37% phosphoric acid for 30 seconds. Group 3 was applied with sealant after acid etching. Group 4 was applied with resin paste after acid etching and sealant application. Each group was demineralized in artificial caries solution. Demineralized enamel depth was measured by confocal laser scanning microscopy. The results were as follows: the mean demineralized enamel depth was 47.4 ㎛ (Group 1), 61.8 ㎛ (Group 2), 13.9 ㎛ (Group 3), 8.2 ㎛ (Group 4) the demineralized enamel depth was increased in Group 2 than in Group 1 (p < 0.05) the demineralized enamel depth was reduced in Group 3 than in Group1 and Group 2 with statistically significant differences (p < 0.05) and demineralization in Group 4 was very little. The results of the present study indicate that sealant application is useful for reducing enamel demineralization in orthodontic bracket bonding.

ZnO:In 가스 감지막의 특성 및 응용

김영범,박종아,김진해,김권태,김정규,마대영,박기철 경상대학교 생산기술연구소 2001 工學硏究院論文集 Vol.1 No.-

The microsensors to detect NH3 gas were fabricated by continous deposition of In film by evaporation and ZnO film by rf magnetron sputtering onto the Si3N4 diaphragm that was prepared by MEMS technology. The sensors were heat-treated to dope In into the ZnO thin film. The electrical characteristics of sensitive films were studied as a function of heat-temperature by 4-point probing method and electrometer. The dependence of the sensitivity, selectivity and time response of sensor on heat-treatment temperature was investigated. The microsensor heat-treated at 400℃ that 3000 A ZnO:In film was chosen as gas sensitive film, showed the highest sensitivity 23% at 350ppm NH3 under 366mW heater power. The time response was 90sec. The sensitivity for CO and NOx was not observed.