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Ko, Kwang-Pil,Park, Sue K,Park, Boyoung,Yang, Jae Jeong,Cho, Lisa Y,Kang, Chungwon,Kim, Cheong Sik,Gwack, Jin,Shin, Aesun,Kim, Yeonju,Kim, Jeongseon,Yang, Han-Kwang,Kang, Daehee,Chang, Soung-Hoon,Shin American Association for Cancer Research 2010 Cancer Epidemiology, Biomarkers & Prevention Vol.19 No.5
<P>BACKGROUND: The role of soybean products in gastric cancer risk is not clear in epidemiologic studies due to measurement error from dietary intake questionnaires and due to different degrees of bias according to study design. To examine the association between soybean products and gastric cancer risk, we measured phytoestrogen biological markers in a nested case-control study. METHODS: The study population was composed of 131 cases and 393 matched controls within the Korean Multicenter Cancer Cohort. The concentrations of the four biomarkers in the plasma samples were measured using time-resolved fluoroimmunoassay. Conditional and unconditional logistic regression models were used to compute the odds ratio (OR) and 95% confidence intervals (CI). RESULTS: Median plasma concentrations of genistein (229 nmol/L for controls, 181.8 nmol/L for cases; P=0.07) and daidzein (131.2 nmol/L for controls, 80.5 nmol/L for cases; P=0.04) in cases were lower than in controls, whereas equol concentrations were similar. Compared with the reference group, gastric cancer risk decreased in the highest groups for genistein (OR, 0.54; 95% CI, 0.31-0.93) and daidzein (OR, 0.21; 95% CI, 0.08-0.58). Higher equol concentrations were associated with a decreased risk for gastric cancer (OR, 0.50; 95% CI, 0.27-0.90). The combination of the highest concentrations for each isoflavone category was associated with a 0.09-fold decreased risk for gastric cancer compared with the combination of the lowest concentrations for each category. There was no association between plasma lignan concentrations and gastric cancer. CONCLUSIONS: High serum concentrations of isoflavones were associated with a decreased risk for gastric cancer. IMPACT: These results suggest a beneficial effect of high soybean product intake for gastric cancer risk.</P>
Intake of Soy Products and Other Foods and Gastric Cancer Risk: A Prospective Study
Ko, Kwang-Pil,Park, Sue K.,Yang, Jae Jeong,Ma, Seung Hyun,Gwack, Jin,Shin, Aesun,Kim, YeonJu,Kang, Daehee,Chang, Soung-Hoon,Shin, Hai-Rim,Yoo, Keun-Young Japan Epidemiological Association 2013 Journal of epidemiology Vol.23 No.5
<P><B>Background</B></P><P>Gastric cancer, the most common cancer in the world, is affected by some foods or food groups. We examined the relationship between dietary intake and stomach cancer risk in the Korean Multi-Center Cancer Cohort (KMCC).</P><P><B>Methods</B></P><P>The KMCC included 19 688 Korean men and women who were enrolled from 1993 to 2004. Of those subjects, 9724 completed a brief 14-food frequency questionnaire at baseline. Through record linkage with the Korean Central Cancer Registry and National Death Certificate databases, we documented 166 gastric cancer cases as of December 31, 2008. Cox proportional hazard models were used to estimate relative risks (RRs) and 95% CIs.</P><P><B>Results</B></P><P>Frequent intake of soybean/tofu was significantly associated with reduced risk of gastric cancer, after adjustment for age, sex, cigarette smoking, body mass index, alcohol consumption, and area of residence (<I>P</I> for trend = 0.036). We found a significant inverse association between soybean/tofu intake and gastric cancer risk among women (RR = 0.41, 95% CI: 0.22–0.78). Men with a high soybean/tofu intake had a lower risk of gastric cancer, but the reduction was not statistically significant (RR = 0.77, 95% CI: 0.52–1.13). There was no interaction between soybean/tofu intake and cigarette smoking in relation to gastric cancer risk (<I>P</I> for interaction = 0.268).</P><P><B>Conclusions</B></P><P>Frequent soybean/tofu intake was associated with lower risk of gastric cancer.</P>
Ko, Kwang-Pil,Park, Sue K.,Cho, Lisa Y.,Gwack, Jin,Yang, Jae Jeong,Shin, Aesun,Kim, Cheong Sik,Kim, Yeonju,Kang, Daehee,Chang, Soung-Hoon,Shin, Hai-Rim,Yoo, Keun-Young Oxford University Press 2009 The Journal of nutrition Vol.139 No.5
<P>In this study, our aim was to investigate the association of inflammation-related genetic polymorphisms and gastric cancer risk and to examine whether the combined effect of soybean product intake modified cancer risk. Eighty-four incident gastric cancer cases and 336 matched controls were selected from the Korean Multi-Center Cancer Cohort. We selected 14 single nucleotide polymorphisms (SNP) from 5 genes [interleukin (IL)-1beta, IL-2, IL-4, IL-8, and IL-10] and used unconditional logistic regression model to calculate the odds ratios (OR) and 95% CI adjusting for H. pylori seropositivity, smoking, age, sex, enrollment year, and residential area. The risk for gastric cancer in relation to genetic polymorphisms and haplotypes were assessed according to soybean product intake levels. Although no single SNP effect was found, the combined effect between IL-10 gene variants of -592 GG/GA, -819 TC/CC, or -1082 AG/GG and low intake of soybean products had an increased risk for gastric cancer compared with the group with no risk gene variants and a high intake of soybean products (OR [95% CI] = 2.82 [1.04-7.62], 2.75 [1.02-7.44], and 4.34 [1.51-12.5], respectively). Among the low-soybean product intake group, IL-10 CCG haplotype had an increased risk of gastric cancer (OR = 3.38 [1.40-8.13]) relative to the ATA haplotype. Our results suggest that the association between IL-10 genetic polymorphisms and gastric cancer risk was modified by soybean product intake.</P>
Ecological study for refrigerator use, salt, vegetable, and fruit intakes, and gastric cancer.
Park, Boyoung,Shin, Aesun,Park, Sue K,Ko, Kwang-Pil,Ma, Seung Hyun,Lee, Eun-Ha,Gwack, Jin,Jung, En-Joo,Cho, Lisa Y,Yang, Jae Jeong,Yoo, Keun-Young Rapid Communications of Oxford Ltd ; Kluwer Academ 2011 Cancer causes & control Vol.22 No.11
<P>We used an ecological approach to determine the correlation between vegetable, fruit and salt intakes, refrigerator use, and gastric cancer mortality in Korean population. Information on fruit and vegetable intakes per capita from the National Health and Nutrition Survey, death certificate data from the National Statistical office, refrigerator per household data from Korean Statistical Information Service, and salt/sodium intake data from a cross-sectional survey were utilized. Correlation coefficients were calculated between vegetable and fruit intakes, refrigerator per household, and gastric cancer mortality and between salt and sodium intakes, and gastric cancer mortality and incidence in the four areas. With 5, 10, and 15?years lag time, refrigerator usage and fruit intake were negatively associated with gastric cancer mortality (p?<?0.01), but vegetable intake was not associated with gastric cancer mortality. When estimates of salt/sodium intake evaluated by 24-h urine collection in four areas of Korea were compared to the gastric cancer mortality and incidence in these regions, positive correlation was shown between salt/sodium intake, and gastric cancer incidence and mortality. Negative associations between refrigerator use, fruit intake, and gastric cancer mortality and positive associations between salt/sodium intake and gastric cancer mortality and incidence were suggested.</P>
The Korea Cohort Consortium: The Future of Pooling Cohort Studies
Sang-Jun Lee,Kwang-Pil Ko,Jung Eun Lee,Inah Kim,Sun Ha Jee,Aesun Shin,Sun-Seog Kweon,Min-Ho Shin,Sangmin Park,Seungho Ryu,Sun Young Yang,Seung Ho Choi,Jeongseon Kim,Sang-Wook Yi,Daehee Kang,Keun-Young 대한예방의학회 2022 예방의학회지 Vol.55 No.5
Objectives: We introduced the cohort studies included in the Korean Cohort Consortium (KCC), focusing on large-scale cohort studies established in Korea with a prolonged follow-up period. Moreover, we also provided projections of the follow-up and estimates of the sample size that would be necessary for big-data analyses based on pooling established cohort studies, including population-based genomic studies. Methods: We mainly focused on the characteristics of individual cohort studies from the KCC. We developed “PROFAN”, a Shiny application for projecting the follow-up period to achieve a certain number of cases when pooling established cohort studies. As examples, we projected the follow-up periods for 5000 cases of gastric cancer, 2500 cases of prostate and breast cancer, and 500 cases of non-Hodgkin lymphoma. The sample sizes for sequencing-based analyses based on a 1:1 case-control study were also calculated. Results: The KCC consisted of 8 individual cohort studies, of which 3 were community-based and 5 were health screening-based cohorts. The population-based cohort studies were mainly organized by Korean government agencies and research institutes. The projected follow-up period was at least 10 years to achieve 5000 cases based on a cohort of 0.5 million participants. The mean of the minimum to maximum sample sizes for performing sequencing analyses was 5917-72 102. Conclusions: We propose an approach to establish a large-scale consortium based on the standardization and harmonization of existing cohort studies to obtain adequate statistical power with a sufficient sample size to analyze high-risk groups or rare cancer subtypes.
Cho, Lisa Y.,Yang, Jae Jeong,Ko, Kwang‐,Pil,Park, Boyoung,Shin, Aesun,Lim, Min Kyung,Oh, Jin‐,Kyoung,Park, Sohee,Kim, Yoon Jun,Shin, Hai‐,Rim,Yoo, Keun‐,Young,Park, Sue K. Wiley Subscription Services, Inc., A Wiley Company 2011 International journal of cancer: Journal internati Vol.128 No.1
<P><B>Abstract</B></P><P>A subadditive effect of hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection is possible because superinfection of one virus tends to inhibit infection of the other virus. However, studies have reported inconsistent findings, and two meta‐analyses of studies from various countries (1998) and China (2005) reported a supraadditive effect for hepatocellular carcinoma (HCC) risk. Thus, we reevaluate HBV/HCV monoinfection and coinfection. Of 411 reports, we included 59 studies that assessed the association between HBV/HCV monoinfection and coinfection for HCC risk. HCC risk because of high/detectable HBV DNA and HBeAg infection was higher than HBsAg infection, whereas anti‐HCV <I>vs</I> anti‐HCV/HCV RNA was not different. Geographically, HCC risk was significantly higher in nonendemic than in HBV or HCV endemic areas. Subadditive effect for HCC risk was presented in recently published studies, cohort studies and studies conducted in HBV/HCV nonendemic areas; an additive effect was presented in studies conducted in HBV endemic areas; a supraadditive effect was presented in previously published studies, case‐control studies and studies conducted in HCV endemic areas. Our results suggest HBV/HCV coinfection for HCC risk is not significantly greater than HBV/HCV monoinfection, and HCC risk due to HBV or HCV is higher in nonendemic than endemic areas. The <I>p‐heterogeneity</I> was significant for most analyses, except HBV(+)/HCV(+) and HBV biomarker analyses. Prevention strategies targeted toward HBV or HCV monoinfected patients are needed. In addition, tailored prevention to reduce infectivity such as HBV markers (HBeAg, HBV DNA) is needed.</P>
Yang, Jae Jeong,Yang, Ji Hyun,Kim, Jungkon,Ma, Seung Hyun,Cho, Lisa Y.,Ko, Kwang‐,Pil,Shin, Aesun,Choi, Bo Youl,Kim, Hyun Ja,Han, Dong Soo,Eun, Chang Soo,Song, Kyu Sang,Kim, Yong Sung,Chang, Sou Wiley Subscription Services, Inc., A Wiley Company 2013 International journal of cancer: Journal internati Vol.132 No.9
<P><B>Abstract</B></P><P>This study was conducted to evaluate the relevance of the soluble form of c‐Met protein, a truncated form of the c‐Met membrane receptor involved in the CagA pathway, as a potential biomarker for gastric cancer. Among 290 gastric cancer case‐control sets selected from the Korean Multicenter Cancer Cohort, the plasma concentrations of soluble c‐Met protein were measured with enzyme‐linked immunosorbent assays. Using analysis of variance and covariance models with age, sex, smoking, <I>Helicobacter pylori</I> infection, and CagA seropositivity, the mean concentrations of soluble c‐Met protein between cases and controls were compared. To evaluate the association between gastric cancer and a c‐Met protein level, odds ratios and 95% confidence intervals were estimated using conditional logistic regression models. Interactions between CagA‐related genes and the soluble c‐Met protein concentration were also investigated. The overall median plasma concentration of soluble c‐Met among cases was significantly lower than those of controls (1.390 <I>vs</I>. 1.610 ng/mL, <I>p</I> < 0.0001). Closer to the onset of gastric cancer, the soluble c‐Met protein level decreased linearly in a time‐dependent manner (<I>p</I> for trend = 0.0002). The combined effects between the CagA‐related genes and the soluble c‐Met protein concentration significantly intensified risks for gastric cancer. Restricted analyses including cases that had been diagnosed within 1 year after entering the cohort had a fair degree of ability (area under the receiver operating characteristic curve of 0.73–0.77) to discriminate gastric cancer cases from normal controls. Our findings demonstrate the potential of the soluble form of c‐Met protein as a novel biomarker for gastric cancer. The beneficial effects of a high soluble c‐Met concentration in human plasma are strongly supported.</P>