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Kum, Rauf Oguzhan,Ozcan, Muge,Baklaci, Deniz,Kum, Nurcan Yurtsever,Yilmaz, Yavuz Fuat,Gungor, Volkan,Unal, Adnan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
Background: Laryngeal carcinogenesis is a multifactorial process that has not been fully elucidated. Despite extensive research, reliable markers with diagnostic and prognostic value are still lacking. It was recently reported that an elevated preoperative neutrophil-to-lymphocyte ratio (NLR) may correlate with an increased risk of recurrence, tumor aggressiveness and poorer prognosis in various malignancies. The aim of this study was to examine whether NLR could be used as an inflammatory marker to differentiate laryngeal squamous cell carcinoma (LSCC) patients from benign laryngeal lesion (BLL) and precancerous laryngeal lesion (PLL) patients. Materials and Methods: This retrospective study was performed on 209 patients admitted to a tertiary referral center with laryngeal lesions and undergoing biopsies to establish their histopathological diagnosis. We reviewed the patient files for their clinical, histopathological and laboratory data. The patients were divided into three groups according to their histopathological findings, as BLL, PLL and LSCC groups. The patients in the PLL group were also divided into three subgroups as mild, moderate and severe dysplasia/carcinoma in situ (CIS) subgroups. The groups were compared for NLR and the other laboratory data. Results: The mean NLRs of the BLL, PLL and the LSCC groups were $2.12{\pm}0.86$, $2.32{\pm}0.68$ and $3.46{\pm}1.51$, respectively, and the difference was statistically significant (p=0.001). The mean NLRs of the patients with PLL and LSCC were significantly higher than the patients with BLL (p=0.031 and p=0.001, respectively). The mean NLRs were similar among mild dysplasia, moderate dysplasia and severe dysplasia / CIS groups (p>0.05). Conclusions: To our knowledge, this is the first study investigating NLR in BLL, PLL and LSCC. NLR is an inexpensive, reproducible and widely available blood test, and could be a useful inflammatory marker to differentiate LSCC from BLL and PLL.
A Systematic Review of Use Cases based Software Testing Techniques
Asad Masood Qazi,Adnan Rauf,Nasir Mehmood Minhas 보안공학연구지원센터 2016 International Journal of Software Engineering and Vol.10 No.11
Use case based Software testing concerned with testing an entire system’s functionality and its constraints. User’s requirements can be drawn in form of use cases to show the internal and external behaviour of a system. The use case has been used to test software system for different levels as well as through many ways according to nature of software. Rather than proposing a new technique, it is necessary to synthesize the existing techniques of Use case based software testing which is available in the literature. A Systematic Literature Review has been performed to investigate all the current approaches of Use case based software testing techniques. A question-wise analysis has also been presented for the researchers to investigate the effectiveness of these techniques. In results, we have discussed all the existing approaches of Use case based software testing along with its strengths & weaknesses and measure the characteristics of these approaches based on some key parameters. We have concluded the current state of the art of all the existing approaches of Use case based testing. Results are based on both types of analysis; Qualitative as well as Quantitative.