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        Comparison Between Sodium Acetate and Sodium Chloride in Parenteral Nutrition for Very Preterm Infants on the Acid-Base Status and Neonatal Outcomes

        Adli Ali,Ee-Yan Ong,Birinder Kaur Sadu Singh,Fook-Choe Cheah 대한소아소화기영양학회 2020 Pediatric gastroenterology, hepatology & nutrition Vol.23 No.4

        Purpose: To compare between sodium acetate (SA) and sodium chloride (SC) in parenteral nutrition (PN) with associated metabolic acidosis and neonatal morbidities in preterm infants. Methods: Preterm infants below 33 weeks gestational age, and with a birth weight under 1,301 g were enrolled and further stratified into two groups: i) <1,000 g, or ii) ≥1,000 g in birth weight. The subjects were randomized to receive PN containing SA or SC within the first day of life. The results of routine blood investigations for the first 6 days of PN were collated, and the neonatal outcomes were recorded upon discharge or demise. Results: Fifty-two infants entered the study, with 26 in each group: 29 infants had extremely low birth weight (ELBW). There were no significant differences in birth weight, gestation, sex, exposure to chorioamnionitis and antenatal steroids, surfactant doses and duration of mechanical ventilation between groups. The SA group had significantly higher mean pH and base excess (BE) from days 4 to 6 than the SC (mean pH, 7.36 vs. 7.34; mean BE −1.6 vs. −3.5 [p<0.01]), with a two-fold increase in the mean BE among ELBW infants. Significantly fewer on SA required additional bicarbonate (n=4 vs. 13, p=0.01). The rate of bronchopulmonary dysplasia (BPD) was approximately four-fold lower in SA than SC (n=3 vs. 11, p<0.01). No significant differences were observed in necrotizing enterocolitis, patent ductus arteriosus, retinopathy of prematurity, cholestatic jaundice, and mortality between groups. Conclusion: The use of SA in PN was associated with reduced metabolic acidosis and fewer BPD.

      • SCOPUSKCI등재

        Comparison Between Sodium Acetate and Sodium Chloride in Parenteral Nutrition for Very Preterm Infants on the Acid-Base Status and Neonatal Outcomes

        Ali, Adli,Ong, Ee-Yan,Singh, Birinder Kaur Sadu,Cheah, Fook-Choe The Korean Society of Pediatric Gastroenterology 2020 Pediatric gastroenterology, hepatology & nutrition Vol.23 No.4

        Purpose: To compare between sodium acetate (SA) and sodium chloride (SC) in parenteral nutrition (PN) with associated metabolic acidosis and neonatal morbidities in preterm infants. Methods: Preterm infants below 33 weeks gestational age, and with a birth weight under 1,301 g were enrolled and further stratified into two groups: i) <1,000 g, or ii) ≥1,000 g in birth weight. The subjects were randomized to receive PN containing SA or SC within the first day of life. The results of routine blood investigations for the first 6 days of PN were collated, and the neonatal outcomes were recorded upon discharge or demise. Results: Fifty-two infants entered the study, with 26 in each group: 29 infants had extremely low birth weight (ELBW). There were no significant differences in birth weight, gestation, sex, exposure to chorioamnionitis and antenatal steroids, surfactant doses and duration of mechanical ventilation between groups. The SA group had significantly higher mean pH and base excess (BE) from days 4 to 6 than the SC (mean pH, 7.36 vs. 7.34; mean BE -1.6 vs. -3.5 [p<0.01]), with a two-fold increase in the mean BE among ELBW infants. Significantly fewer on SA required additional bicarbonate (n=4 vs. 13, p=0.01). The rate of bronchopulmonary dysplasia (BPD) was approximately four-fold lower in SA than SC (n=3 vs. 11, p<0.01). No significant differences were observed in necrotizing enterocolitis, patent ductus arteriosus, retinopathy of prematurity, cholestatic jaundice, and mortality between groups. Conclusion: The use of SA in PN was associated with reduced metabolic acidosis and fewer BPD.

      • KCI등재

        Maintenance Dose of Vitamin D: How Much Is Enough?

        Mir Sadat-Ali,Fawaz M. Al-Anii,Haifa A. Al-Turki,Adeebah Abdulaziz AlBadran,Sa’ad Mohammed AlShammari 대한골대사학회 2018 대한골대사학회지 Vol.25 No.3

        Background: It is still unclear the ideal vitamin D dosage once the deficiency and insufficiency is treated. Once deficiency was corrected we prospectively treated patients with 2,000 IU of vitamin D3 to check whether this dosage is enough to keep them above the 30 ng/mL of 25-hydroxy-vitamin D (25[OH]D). Methods: One hundred and thirty-five Saudi Arabian men and women treatment naïve for the vitamin D deficiency and insufficiency were part of this study. History and clinical examination were done to rule out any metabolic bone disease. Weight and height was taken to calculate the body mass index (BMI). Patients who were vitamin D deficient (≥30 ng/mL), a standard treatment of 50,000 IU of vitamin D3 weekly for 3 months, a blood test for the vitamin D levels at the end of 3 months, maintenance dose of 2,000 IU of vitamin D3 for 3 months and a third blood sample after 3 months. Results: The data for 128 patients was available for analysis. The average age was 44.95±12.97 years with the mean BMI of 29.60±2.59 kg/m2. The baseline 25(OH)D level was 13.16±3.30 ng/mL. The increase in the level of 25(OH)D on 50,000 IU weekly was significant from 13.16±3.3 ng/mL to 36.97±4.67 ng/mL (P<0.001) and then 2,000 IU daily for next 3 months, the level of 25(OH)D dropped top 20.38±5.42 ng/mL (P<0.001). Conclusions: Our study indicates that the maintenance dose of 2,000 IU of vitamin D is not enough for patients to keep the 25(OH)D levels above 30 ng/mL.

      • KCI등재

        Electrospun Porous Polylactic Acid Fibers Containing CdS for Degradation of Methylene Blue

        Chit Seng Ho,Nur Hafizah Zainal Abidin,Muhammad Wahyu Nugraha,Nonni Soraya Sambudi,Fathilah Ali,MOHD Dzul Hakim Wirzal,Laksmi Dewi Kasmiarno,Sarah Amalina Adli 한국섬유공학회 2020 Fibers and polymers Vol.21 No.6

        The immobilization of photocatalyst in polymer fibers has been found to improve photodegradation of dye andrecyclability of material. In this study, porous polylactic acid (PLA) fibers were utilized as photocatalyst support usingelectrospinning technique to synthesis the fibers. The cadmium sulfide (CdS) was embedded in fibers at the amount of1 wt%, 3 wt%, and 5 wt% as photocatalyst agent with absorption in visible light range. The electrospun fibers experiencedincreasing in diameter for 2.6 times (from 175 nm to 450 nm), due to incorporation of CdS. The synthesized CdS has bandgap of 2.35 eV, and its presence in composite fibers can be detected by using energy dispersive X-ray (EDX) and X-raydiffraction (XRD) analyses. The photodegradation was performed under low-powered halogen lamp, with 90 % removal ofmethylene blue (MB) after 10 hours of irradiation using CdS(3 wt%)/PLA fibers. This result shows higher performance incomparison with PLA and CdS which could only remove 57 % and 65 % of MB, respectively. The recyclability of compositewas tested with satisfying performance; with around 60 % of MB removal was maintained after five times of recycleexperiments.

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