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RISS 인기검색어
- 검색키워드
- 저자 : Abdullah Saglam (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Gunay Gurleyik,Fugen Aker,Ali Aktekin,Abdullah Saglam 한국유방암학회 2011 Journal of breast cancer Vol.14 No.2
Purpose: The negative sentinel lymph node (SLN) biopsy avoids conventional axillary dissection in patients with breast cancer with clinically negative axilla. Despite negative SLN, there is a risk of leaving involved non-SLN behind in the axilla. We investigated the predictive power of tumor characteristics for non-SLN metastasis. Methods: Lymphatic mapping with blue dye method for SLN biopsy and level 1-2 axillary dissections were performed to establish axillary status in 59 patients with T1 and T2 breast cancer and clinically negative axilla. Tumor’s characteristics were histopathologically established to assess their association with non-SLN metastasis. Results: The axilla was malignant in 23 (39%) patients. The SLN alone was metastatic in 10, both SLN and non-SLN in 9, and non-SLN alone in 4 (7%) patients. The false negative rate for SLN biopsy was 10% in our series. The rate of positive non-SLN was found as 0% in T1a-b, 19% in T1c, and 40% in T2 tumors (p=0.035). Lymphovascular invasion was positive in 14 (61%) patients with axillary metastasis (p<0.001), and in 10 (77%) patients with non-SLN involvement (p<0.001). Conclusion: We concluded that there was a small risk of involved non-SLN despite negative SLN. Tumor size (near or greater than 2 cm) was significantly associated with non-SLN metastasis. Peritumoral lymphovascular invasion was a positive predictor of the metastatic involvement in non-SLNs.
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Gunay Gurleyik,Ali Aktekin,Fugen Aker,Hikmet Karagulle,Abdullah Saglam 한국유방암학회 2012 Journal of breast cancer Vol.15 No.1
Purpose: Idiopathic granulomatous lobular mastitis (IGLM) is a rare chronic inflammatory disease of the breast with obscure etiology that mimics invasive carcinoma both clinically and radiologically. The treatment of IGLM remains controversial. The aim of proper management is to use a combination of medical and surgical treatment of this benign condition to achieve a good cosmetic result and low recurrence rate. Methods: A retrospective analysis of 19 patients with IGLM is performed based on the findings of clinical, radiological, and pathological examinations. The results of two treatments are presented: medical treatment with oral corticosteroids, and consecutive surgical excision after a follow-up period of 20 months (range, 6-75 months). Results: The majority of patients treated in this paper were young (mean,34 years) parous women with a history of hormonal medication use. The main clinical finding is large, irregular, and painful mass. Hypoechoic lobulated, irregular tubular or oval shaped masses had been imaged by ultrasound. Mammographic findings were an ill-defined mass, enlarged axillary lymph nodes, asymmetric density, and architectural distortion. Diagnoses of IGLM had been established by cytological or histological examination. Symptoms subside and inflammatory changes regressed with medical treatment. The remaining lesions were excised by consecutive breast conserving surgery. The disease recurred in one patient during the follow-up period. Conclusion: IGLM is an inflammatory breast disease found in young women who present with a large painful irregular mass, which mimics carcinoma, as a physical change. Breast imaging modalities are not helpful to differentiate IGLM from invasive cancer. The correct diagnosis is established by cytological or histological examination. Medical treatment with corticosteroids provides significant regression of the inflammatory disease, allowing more conservative surgery. Consecutive surgical excision of the remaining lesions with good cosmetic results provides definitive treatment and reduces the risk of recurrence.
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Serkan Mutlu,Adem Parlak,Umit Aydogan,Aydogan Aydogdu,Bugra Soykut,Cemal Akay,Kenan Saglam,Abdullah Taslipinar 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.8
The purpose of this present study is to investigatethe levels of oxidative stress parameters in patientswith subclinical hypothyroidism (SH) and the effects oflevothyroxine (LT4) replacement therapy on these parametersand lipid profile. At the beginning of the study bloodsamples were collected from the patients in order to analyseoxidative stress parameters, lipid profile and biochemicalmarkers. After replacement therapy with LT4, inthe third month, same tests were performed again. At thebaseline superoxide dismutase (SOD) levels were found tobe higher in SH patients, compared to the euthyroid group. After LT4 therapy, statistically significant decreases inSOD and catalase levels and increase in HDL-C levelswere noticed. LT4 treatment was found to have positiveeffects on oxidative stress indicators and HDL-C levels.
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