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      저자 : A. F. M. Mahmudul Islam (검색결과 1 건)
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        Evaluation of microbiological and physicochemical profile of some herbal preparations manufactured by pharmaceutical and herbal manufacturers in Bangladesh

        A. F. M. Mahmudul Islam,Md. Farhan Khalik,Nizam Uddin,Md. Sazzad Hossain,Md. Monir Hossain,Md. Mahadi Hasan,S. M. Fahad,Pijus Saha 한국약제학회 2015 Journal of Pharmaceutical Investigation Vol.45 No.2

        The aim of this study was to scrutinize thephysicochemical and qualitative microbial examination of 30 different (of various dosage forms) herbal medicinalproducts marketed by pharmaceutical and herbal manufacturersin Bangladesh. The microbial evaluation includedtotal viable aerobic bacteria, Escherichia coli, fungi andStaphylococcus aureus count; physicochemical propertieslike weight variation, hardness, disintegration time, friabilityand density. The IMViC (indole, methyl red, Voges–Proskauer and citrate utilization) tests were frequentlyemployed for identification of E. coli and S. aureus. Totalviable aerobic bacterial counts in the samples analyzed wereranged from 3.8 × 10⁴ to 3.2 × 108 CFU/ml or CFU/g and 36.67 % were within BP standard limit. S. aureus wasdetected in 53.33 % (16) of the samples, ranged from anestimated 3 × 10² to 9.2 × 106 CFU/ml or CFU/g whichwere above the USP standard. E. coli was detected in 40 %(12) of the samples, ranging from 1 × 10² to 4.8 × 10⁴CFU/ml or CFU/g that were above the USP standard. Theranges of the fungi counts were 3.4 × 10³ – 3.1 × 106 CFU/ml or CFU/g and 46.67 %of which were within BP standard. Physicochemical properties of herbal products manufacturedby pharmaceutical manufacturers were found betterthan that of the herbal manufacturers. From the label andpack insert of herbal products, definite release patterninformation weren’t obtained and the majority of herbalproducts showed scattered disintegration time. In order toreduce the potential health related complications, there isnecessity of constant monitoring and control of the standardsof herbal medicine products available in the Bangladeshimarket.

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