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- 저자 : A. Hurtado‑Macias (검색결과 2 건)
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Ramírez-Patiño Ramiro,Figuera Luis Eduardo,Puebla-Pérez Ana María,Delgado-Saucedo Jorge Ivan,Legazpi-Macias María Magdalena,Mariaud-Schmidt Rocio Patricia,Ramos-Silva Adriana,Gutiérrez-Hurtado Itzae A 대한의학회 2013 Journal of Korean medical science Vol.28 No.11
The endothelial nitric oxide synthase (eNOS) gene plays an important role in several biological functions. Polymorphisms of the eNOS gene have been associated with cancer. It has been suggested that the VNTR 4 a/b polymorphism may affect the expression of eNOS and contributes to tumor promotion in the mammary gland. We examined the role of the eNOS4 a/b polymorphism by comparing the genotypes of 281 healthy Mexican women with the genotypes of 429 Mexican women with breast cancer (BC). The observed genotype frequencies for control and BC patients were 0.6% and 0.7% for a/a (polymorphic); 87% and 77% for a/a (wild type); and 12% and 22% for a/b respectively. We found that the odds ratio (OR) was 1.9, with a 95% confidence interval (95%CI) of 1.29-2.95, P=0.001 for genotypes a/a-a/b, b/c. The association was also evident when comparing the distribution of the a/a-a/b genotypes in patients with high levels of glutamate-oxaloacetate transaminase (SGOT) (OR, 1.93; 95% CI, 1.14-3.28; P=0.015); undergoing menopause with high levels of SGOT (OR, 2.0; 95% CI, 1.1-3.84); and with high levels of glutamic-pyruvic transaminase (SGPT) (OR, 3.5; 95% CI, 1.56-8.22). The genotypes a/a-a/b are associated with BC susceptibility in the analyzed samples from the Mexican population.
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E. Contreras,D. Grisales,W. Tillmann,A. Hurtado‑Macias,M. A. Gómez‑Botero 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.8
Due to its high hardness, chemical and thermal resistance, TiB2has become a great candidate to be used as a protective coating. However, high residual stresses after the deposition and brittleness have become the main obstacles for implementation atindustrial levels. In the present work, the incorporation of graphite was studied as an alternative to improve the performanceof the TiB2coatings and study the influence in the microstructure, Nano mechanical and tribological properties. Ti–B–Ccoatings were deposited with different carbon contents of 10, 20, 28 and 38 at%. XRD results showed that the carbon atomsenter within the crystal lattice of the TiB2forming a solid solution, and consequently, deforming crystal and modifying itslattice parameter of 3.2237–3.3414 Å. HRTEM images and selected area electron diffraction patterns analysis display thelow crystallite or degree of amorphosity due to the carbon concentration (C1.9 mol). Compressive residual stresses decreasein the coatings containing the higher amounts of carbon. The formation of a TiB2-C solid solution contributed to the incrementof nanohardness (H = 25 GPa) and improvement of the resistance to plastic deformation (H3/E2) of coatings. Regardingthe tribological behaviour of the coatings, higher friction coefficient than those obtained on the uncoated substrate wereobserved. However, a reduction of the wear rate was also evident. The presence of a high amount of debris and severe wearof the counterpart material indicates a highly aggressive tribological contact. Roll-like debris with a shape of needles wasfound within the tribological tracks perpendicular to the sliding direction.
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