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A Situational Assessment of Children Living with HIV and AIDS in Bangalore
Christy Abraham Research Institute of Asian Women Sookmyung Women' 2005 Asian Women Vol.21 No.-
In its efforts to combat the HIV and AIDS epidemic in India, the National AIDS Control Organization (NACO) in line with Government's efforts has developed an integrated work plan on combating the disease. NACO and the State AIDS Control Societies' primary activity targeting children has been prevention of mother-to-child transmission, which involves administering a short course of antiretroviral drugs to mother and newborn that greatly reduces the risk of HIV transmission during pregnancy and child birth. The most vulnerable group of the population, the HIV positive children and children who are now orphans due to the death of one or both of their parents from AIDS, have received little attention both in terms of practical programs and in sector plans. This is much so because the number of AIDS orphans in the country is not known let alone their living conditions and their needs as other children. This paper assesses the situation of 100 children who are living with HIV and AIDS and who are now orphans due to the death of one or both of their parents from AIDS and the concerns and challeges of positive mothers in Bangalore, India. While 63 children live with their families 36 positive children live in one of the Positive Children's Homes in Bangalore. Out of the 64 positive children, 30 children are paternal orphans, three children are maternal orphans, and nine children are double orphans. Thirteen children are living with their positive parents and the double orphans live with their extended families. The information was gathered in individual therapy sessions, group discussions, and family support sessions with positive children and widows. Out of the 36 Positive Children in the institution, 26 are double orphans and 10 children are either maternal orphans or paternal orphans. The paper also gives an insight on how a Family Support Network, MILANA in Bangalore, India, is addressing and coping with the varied issues and problems faced by orphans and their families. The assessment suggests the need to map out the children orphaned by AIDS, so as to get reliable data on the total number of children orphaned by AIDS, and to frame policies for children orphaned by AIDS, taking into consideration not only the educational, health, and nutritional aspects but also the psycho social and economic aspects.
Screening of cell-penetrating antibodies using a cell-free protein synthesis system
( Christy ),( Devi Kasi ),이경호,박유진,박성욱,김용성,김동명 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.0
With its unique open reaction format, cell-free protein synthesis provides a versatile platform for production and screening of heterologus recombinant proteins. In this study, we used the cell-free protein synthesis system for expression screening of cell-penetrating scFv antibodies from a designed mutant library. By streamlining cell-free expression of the library with a cell-based split GFP complementation assay, we could examine the cell-penetration efficiency and stability of individual mutant scFvs in a fast and parallel manner. Cell-free protein synthesis system enables direct access and control over translational conditions, which was proven to be advantageous in high-throughput screening of antibodies.
Cloning-independent engineering of elastin-like polypeptides using unnatural amino acids
( Christy ),오수진,민승의,원종인,윤현동,김동명 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
Based on the central dogma of protein synthesis, traditional methods for protein engineering require that altering protein structure and function must be accompanied by changing the nucleotide sequence of the genes encoding the protein. However, the preparation of a template gene for each individual protein requires a great deal of time and effort, thereby limiting the throughput and scope of studying engineered proteins. In this study, we describe translation-level engineering of proteins using cell-free protein synthesis. Taking advantage of the promiscuity of aminoacyl tRNA synthetases in accepting structurally similar amino acid analogues, unnatural amino acids were introduced into elastin-like polypeptides in place of the corresponding cognate amino acids. Through the incorporation of various analogues and starting from the same gene, the phase transition temperatures of elastin-like polypeptides became tunable. Our results demonstrate the usefulness of cell-free protein synthesis for protein engineering using unnatural amino acids without the need for cloning.
Christy Catherine,오수진,이경호,민승의,원종인,윤형돈,김동명 한국생물공학회 2015 Biotechnology and Bioprocess Engineering Vol.20 No.3
Based on the central dogma of protein synthesis, traditional methods for protein engineering require that altering protein structure and function must be accompanied by changing the nucleotide sequence of the genes encoding the protein. However, the preparation of a template gene for each individual protein requires a great deal of time and effort, thereby limiting the throughput and scope of studying engineered proteins. In this study, we describe translation-level engineering of proteins using cell-free protein synthesis. Taking advantage of the promiscuity of aminoacyl tRNA synthetases in accepting structurally similar amino acid analogues, unnatural amino acids were introduced into elastin-like polypeptides in place of the corresponding cognate amino acids. Through the incorporation of various analogues and starting from the same gene, the phase transition temperatures of elastin-like polypeptides became tunable. Our results demonstrate the usefulness of cell-free protein synthesis for protein engineering using unnatural amino acids without the need for cloning.
Role of solvents on the oxygen reduction and evolution of rechargeable Li-O<sub>2</sub> battery
Christy, Maria,Arul, Anupriya,Zahoor, Awan,Moon, Kwang Uk,Oh, Mi Young,Stephan, A. Manuel,Nahm, Kee Suk Elsevier 2017 Journal of Power Sources Vol.342 No.-
<P><B>Abstract</B></P> <P>The choice of electrolyte solvent is expected to play a key role in influencing the lithium-oxygen battery performance. The electrochemical performances of three electrolytes composed of lithium bis (trifluoromethane sulfonyl) imide (LiTFSI) salt and different solvents namely, ethylene carbonate/propylene carbonate (EC/PC), tetra ethylene glycol dimethyl ether (TEGDME) and dimethyl sulfoxide (DMSO) are investigated by assembling lithium oxygen cells. The electrolyte composition significantly varied the specific capacity of the battery. The choice of electrolyte also influences the overpotential, cycle life, and rechargeability of the battery. Electrochemical impedance spectra, cyclic voltammetry, and chronoamperometry were utilized to determine the reversible reactions associated with the air cathode.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The choice of electrolyte solvent influences the lithium/O<SUB>2</SUB> battery performance. </LI> <LI> Three solvents; TEGDME, ECPC and DMSO exhibit proper reversible reaction. </LI> <LI> TEGDME demonstrate a comparatively suitable electrode – electrolyte combination. </LI> </UL> </P>