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α1,3-Gal Knock out Pigs Increases N-Glycolylneuraminic Acids
Jong-Yi Park,Mi-Ryung Park,Hong-Thuy Bui,Deug-Nam Kwon,Min-Hui Kang,Mihye Oh,Jae-Woong Han,Ssang-Goo Cho1,Chankyu Park,Hosup Shim,Hye-Min Kim,Man-Jong Kang,Jin-Ki Park,Jeong-Woong Lee,Kyung-Kwang Lee 한국동물번식학회 2012 Reproductive & Developmental Biology(Supplement) Vol.36 No.2s
In this study, we examined whether Hanganutziu-Deicher (H-D) antigens are important as an immunogenic non-a1,3-galactose (Gal) epitope in pigs with a disrupted a1,3- galactosyltransferase gene. The targeting efficiency of the AO blood genotype was achieved (2.2%) in pig fibroblast cells. A total of 1800 somatic cell nuclear transfer (SCNT) embryos were transferred to 10 recipients. One recipient developed to term and naturally delivered two piglets. The a1,3-galactosyltransferase activity in lung, liver, spleen, and testis of heterozygote a1,3-galactosyltransferase gene knockout (GalT-KO) pigs was significantly decreased, whereas brain and heart showed very low decreasing levels of a1,3- galactosyltransferase activity when compared to those of control. Enzyme-linked lectinosorbent assay showed that the heterozygote GalT-KO pig had more sialyla2,6- and sialyla2,3- linked glycan than the control. Furthermore, the heart, liver, and kidney of the heterozygote GalT-KO pig had a higher N-glycolylneuraminic acid (Neu5Gc) content than the control, whereas the lung of the heterozygote GalT-KO pig had Neu5Gc content similar to the control. Collectively, the data strongly indicated that Neu5Gc is a more critical xenoantigen to overcoming the next acute immune rejection in pig to human xenotransplantation.
α1,3‐Gal Knock out Pigs Increases N‐Glycolylneuraminic Acids
Jong‐Yi Park,Mi‐Ryung Park,Hong‐Thuy Bui,Deug‐Nam Kwon,Min‐Hui Kang,Mihye Oh,Jae‐Woong Han,Ssang‐Goo Cho,Chankyu Park,Hosup Shim,Hye‐Min Kim,Man‐Jong Kang,Jin‐Ki Park,Jeong‐Woong Lee,Kyung‐Kwang Lee,J 한국동물번식학회 2012 Reproductive & developmental biology Vol.36 No.2
Park, Hyun Jung,Choi, Wahn Soo,Lee, Won Young,Choi, Youngsok,Park, Chankyu,Kim, Jin Hoi,Hong, Kwon Ho,Song, Hyuk Elsevier 2018 Environmental toxicology and pharmacology Vol.58 No.-
<P><B>Abstract</B></P> <P>The pathogenesis of atopic dermatitis (AD) involves T helper 2 (Th2) cells, and effective therapies remain elusive due to the paucity of animal models. We aimed to develop a mouse model of an immune system aberration caused by allergen. Experiments were conducted in two phases. In experiment 1, BALB/c mice were sensitized with one of four chemical allergens – toluene diisocyanate (TDI), hexamethylene diisocyanate (HDI), trimellitic anhydride (TMA), or 2,4-dinitrochlorobenzene (DNCB) – for 3 weeks. Based on results of experiment 1, immunological features were compared between TMA-sensitized BALB/c mice and NC/Nga mice, after exposure to mite extracts, harmful chemicals and detergents in experiment 2. Sensitization by allergen caused a large number of pathological changes in the skin, and an increase in mast cell number. TMA-sensitized BALB/c mice models showed higher sensitivity to an environmental allergen than NC/Nga mice did. Overall, the initial sensitization with TMA leads to disturbances in Th2-mediated immunity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> To develop a mouse model of an immune system aberration caused by a chemical allergen. </LI> <LI> Th2-skewed immune response in TMA-sensitized mice closely mimics human AD. </LI> <LI> TMA-sensitized mice showed higher sensitivity to an environmental allergen than NC/Nga mice. </LI> </UL> </P>
Expression patterns and role of SDF-1/CXCR4 axis in boar spermatogonial stem cells
Park, Hyun Jung,Lee, Won-Yong,Kim, Jin Hoi,Park, Chankyu,Song, Hyuk Elsevier 2018 Theriogenology Vol.113 No.-
<P><B>Abstract</B></P> <P>The signaling of chemokine stromal cell-derived factor (SDF)-1 and its receptor C-X-C motif chemokine receptor 4 (CXCR4) is involved in the cellular proliferation, survival, and migration of various cell types. Although SDF-1/CXCR4 has been implicated in the maintenance of the spermatogonial population during mouse testis development, their expression patterns and functions in boar testis remain unclear. In the present study, the expression pattern of SDF-1 and CXCR4 was determined during pre-pubertal and post-pubertal stage boar testes and <I>in vitro</I> cultured porcine spermatogonial stem cells (pSSCs). The role of these proteins in colony formation in cultured pSSCs was also investigated. Interestingly, SDF-1 expression was observed in PGP 9.5-positve spermatogonia in all developing stages of boar testis; however, CXCR4 expression was only detected in spermatogonia from 5-day-old boar testis. In addition, SDF-1 and CXCR4 expression was observed in cultured pSSCs from 5-day-old boar testes, and inhibition of the CXCR4 receptor signaling pathway by AMD3100 significantly decreased the colony formation of pSSCs. These results suggest that SDF-1 and CXCR4 are useful markers for detecting stage-specific spermatogonia in boar testis. Our results reveal the role of the SDF-1/CXCR4 axis in pSSC <I>in vitro</I> culture.</P> <P><B>Highlights</B></P> <P> <UL> <LI> SDF-1 expression was observed in PGP 9.5-positve spermatogonia in all developing stages of boar testis. </LI> <LI> CXCR4 expression was detected in spermatogonia from 5-day-old boar testis. </LI> <LI> SDF-1 and CXCR4 expression was observed in cultured pSSCs from 5-day-old boar testes. </LI> <LI> Inhibition of the CXCR4 receptor signaling pathway significantly decreased the colony formation of pSSCs. </LI> </UL> </P>
A Wrist-Type Fall Detector with Statistical Classifier for the Elderly Care
( Chankyu Park ),( Jaehong Kim ),( Joo-chan Sohn ),( Ho-jin Choi ) 한국인터넷정보학회 2011 KSII Transactions on Internet and Information Syst Vol.5 No.10
Falls are one of the most concerned accidents for elderly people and often result in serious physical and psychological consequences. Many researchers have studied fall detection techniques in various domain, however none released to a commercial product satisfying user requirements. We present a systematic modeling and evaluating procedure for best classification performance and then do experiments for comparing the performance of six procedures to get a statistical classifier based wrist-type fall detector to prevent dangerous consequences from falls. Even though the wrist may be the most difficult measurement location on the body to discern a fall event, the proposed feature deduction process and fall classification procedures shows positive results by using data sets of fall and general activity as two classes.
Knowledge-Based AOP Framework for Business Rule Aspects in Business Process
Chankyu Park,최호진,이단형,강성원,Hyun-Kyu Cho,Joo-Chan Sohn 한국전자통신연구원 2007 ETRI Journal Vol.29 No.4
In recent years, numerous studies have identified and explored issues related to web-service-oriented business process specifications, such as business process execution language (BPEL). In particular, business rules are an important cross-cutting concern that should be distinguished from business process instances. In this paper, we present a rule-based aspect oriented programming (AOP) framework where business rule aspects contained in business processes can be effectively separated and executed. This is achieved by using a mechanism of the business rule itself at the business rule engine instead of using existing programming languagebased AOP technologies. Through some illustrative examples, this work also introduces a method by which business rule aspects, separated through an external rule engine, can be represented and evaluated. We also demonstrate how they can be dynamically woven and executed by providing an implementation example which uses two open-source-based products, the Mandarax rules engine and Bexee BPEL engine.
Chitosan nanoparticles cause pre- and postimplantation embryo complications in mice.
Park, Mi-Ryung,Gurunathan, Sangiliyandi,Choi, Yun-Jung,Kwon, Deug-Nam,Han, Jae-Woong,Cho, Ssang-Goo,Park, Chankyu,Seo, Han Geuk,Kim, Jin-Hoi Society for the Study of Reproduction [etc.] 2013 BIOLOGY OF REPRODUCTION Vol.88 No.4
<P>Embryo development is a complex and tightly controlled process. Nanoparticle injury can affect normal development and lead to malformation or miscarriage of the embryo. However, the risk that these nanoparticles may pose to reproduction is not clear. In this study, chitosan nanoparticles (CSNP) of near uniform size, in the range of 100 nm, were synthesized and confirmed by a particle size analyzer and transmission electron microscopy. Morulae-stage embryo exposure to CSNP during in vitro culture caused blastocyst complications that had either no cavity or a small cavity. Furthermore, CSNP-treated embryos showed lower expression of not only trophectoderm-associated genes but also pluripotent marker genes. When blastocysts developed in both media with and without CSNP were transferred to recipients, the percentage of blastocysts resulting in viable pups was significantly reduced. These detrimental effects are linked to the reduction of total cell numbers, enhanced apoptosis, and abnormal blastocoels forming at the blastocyst stage, indicating that CSNP treatment might have long-term adverse biological effects in view of pregnancy outcome.</P>
Chankyu Park,William Falls,Jacqueline H. Edgar,Chantal M. Longo-Guess,Susan L. Ackerman 한국실험동물학회 2001 한국실험동물학회 학술발표대회 논문집 Vol.2001 No.-
Positional cloning (map-based cloning) of mutations or genetic variations has been served as an invaluable tool to understand in vivo functions of genes and to identify molecular components underlying phenotypes of interest. Mice homozygous for the cerebellar deficient folia (cdf) mutation are ataxic, with cerebellar hypoplasia and abnormal lobulation of the cerebellum. In the cdf mutant cerebellum approximately 40% of Purkinje cells are ectopically located within the white matter and the inner granule cell layer (IGL). To identify the cdf gene, a high-resolution genetic map for the cdf-gene-encompassing region was constructed using 1997 F2 mice generated from C3H/HeSnJ-cdf/cdf and CAST/Ei intercross. The cdf gene showed complete linkage disequilibrium with three tightly linked markers D6Mit208, D6Mit359, and D6Mit225. A contig using YAC, BAC, and P1 clones was constructed for the cdf critical region to identify the gene. We have identified a deletion in the cdf critical region on Chromosome 6 that removes approximately 150 kb of DNA, including an exon encoding a portion of the actin-binding domain of N-catenin, the protein that links the classical cadherins to the neuronal cytoskeleton. Normal cerebellar and hippocampal morphology was restored in cdf mutant mice expressing an N-catenin cDNA transgene, demonstrating that the catenin/cadherin cell adhesion complexes play an important role in the lamination of the cerebellum and hippocampus. Furthermore, our analysis of mutant mice demonstrates that fear conditioning, a form of associative learning, and prepulse inhibition are disrupted in cdf mutant mice, implicating the involvement of catenin/cadherin complexes in these behavioral processes.
Structure and function of chemotactic transducer proteins
Park, Chankyu,Ha, L.zelbaure The Microbiological Society of Korea 1986 微生物과 産業 Vol.12 No.2
Barcterial chemotaxis is a transient response of an organism in a situation where environmental homogeneity has been disturbed by certain chemical compounds. The phenomenon has been described in motile bacterial species including enteric bacteria, Gram-positives(14), Spirochaetes (6) and even Archaebacteria (8). However, most comprehensive studies have been done with Escherichia coli and Salmonella typhimurium. Two analogies to higher eucaryotic sensory phenomena are provided by the study of bacterial chemotaxis. First, bacterial chemotaxis is similar to the stimulus-response of neuronal, immune and sperm cells. Second, studies of individual components involved in the bacterial sensory pathway can contribute to the understanding of the function of receptors, controling signals and molecular comparators in transmembrane signalling system. The bacterial sensory transducer, a chemoreceptor in a broad sense, is a unique entity for studying sensory function in which sensory reception, signalling and adaptation are integrated (7,18).