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소염진통제 약물에 대한 In vitro 피부자극 시험연구
이종권,김대병,이은희,이선희,류승렬,최기환,김윤정,김부영,Lee, Jong-Kwon,Kim, Dai-Byung,Lee, Eun-Hee,Lee, Sun-Hee,Ryu, Seung-Rel,Choi, Ki-Hwan,Kim, Yoon-Jeong,Kim, Pu-Young 한국독성학회 1998 Toxicological Research Vol.14 No.3
In vitro skin iritation of anti-inflammatory drugs was investigated in terms of the cytotoxicity method to human skin fibroblast cells. Five anti-inflammatory drugs (Diclofenac, Naproxen, Meclofenamic acid, Ibuprofen and Fnoprofen) which are commercially available as oral preparations or injections were tested. The cytotoxicity of 5 chemicals was evaluated by using MTT[tetrazolium salt 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay. NRU (neutral red uptake) assay and Alamar Blue assay after fibroblast cells had been exposed to the chemicals for 24 hours or 489 hours. The $IC_{50}$ values of the chemicals showed the comparative strength of cytotoxicity as following order of Meclofenamic acid>Diclofenac>Fenoprofen>Ibuprofen>Naproxen. The values of $IC_{50}$ determined by Alamar Blue assay were lower than those of MTT and NRU assay. These data suggest Alamar Blue assay can be useful method for assessing in vitro skin irritation potential of anti-inflammatory drugs.
공공도서관의 서비스 질 평가에 관한 실증적 연구-서비스 질 요인이 고객만족 및 고객행태에 미치는 영향-
이종권 한국문헌정보학회 2002 한국문헌정보학회지 Vol.36 No.2
The purpose of this study is to construct a model for measuring and assessing service quality in public libraries based on the theory of service quality in marketing area. Firstly the degree of importance of service factors is measured and ranked according to the value of each factor. This importance ranking indicates the order of service improvement. Secondly the correlation model between service factors and customer’s satisfaction and behaviour is established and verified in statistical method. The result shows that the order of service quality factors which have influence on the customer’s satisfaction and behaviour is the order of service quality factors required preferential improvement. 본 연구의 목적은 마케팅분야의 서비스 질 이론을 활용하여 공공도서관의 서비스 질을 측정하고 평가할 수 있는 모형을 구축하는 데 있다. 이를 위해 본 연구는 우선 고객이 기대하는 서비스 질의 중요 요인을 측정, 분석하여 중요도에 따른 우선 개선 요인의 순위를 도출하였다. 또한 서비스 질 요인과 고객만족의 상관관계 및 서비스 질 요인과 고객행태의 상관관계 모형을 구축하고 이를 통계적 방법으로 검증하여 고객만족과 고객행태에 영향을 미치는 서비스 질 요인들의 우선 순위를 도출하였다.
Balb/c 마우스에서 Local Lymph Node Assay(LLNA)를 01용한 피부 감작성 시험 대체시험법 연구
이종권,황인창,박재현,김형수,정승태,엄준호,오혜영 한국독성학회 2002 Toxicological Research Vol.18 No.2
Allergic contact dermatitis (skin sensitization) may be caused by a wide variety of chemicals. A murine local lymph node assay (LLNA) has been developed as an alternative to guinea pig models for assessing the contact sensitization potential of chemical. This study was carried out to evaluate the skin sensitization potential for chemicals in Balb/c mice by LLNA. Contact allergen, dinitrochlorobenzene (DNCB), respiratory allergen, toluene diisocyanate (TDI) and a weak allergen, $\alpha$-hexlycinnamaldehyde (HCA) were wed as positive chemicals and irritant, sodium lauryl sulfate(SLS) also wed as a reference chemical in this study. The weights of lymph node in the mice treated with DNCB, TDI, and HCA were increased compared to vehicle control. There was a significant increase in lymph node weight of mice treated with high concentration of SLS compared to vehicle control. The stimulation index (SI) of Lymph node cell in the mice treated with DNCB, TDI, and HCA revealed over three-fold increase compared to vehicle control by $3^H$-thymidine uptake. All allergens correctly identified in this LLNA study wing Balb/c mice. These results suggest that LLNA wing Balb/c mice could be a useful method for screening the allergenic potential of chemicals. The expression of IL-2 mRNA was slightly increased in draining auricular lymph node cell of the mice treated with TDI and HCA by RT-PCR. However the IL-2 levels in DNCB and SLS of treated animals were not significantly changed.
이종권 한국논리학회 2006 論理硏究 Vol.9 No.1
Nozick explains Newcomb's problem lies in the fact that two rational principles, which he called Dominace Principle and Principle of Maximizing Expected Utility, yield incompatible results when applied to the Newcomb situation. Schlesinger and Yi attempted to argue for the Dominance Principle. Their arguments are grounded on the analogy between the original Newcomb situation and the Newcomb- like situations they designed. In this paper, it is shown that such analogy either does not hold or is not sufficient enough to provide a solution to the Newcomb's problem. It provides my own argument for the Dominance Principle in the Newcomb situation. 노직은 뉴컴의 문제를 뉴컴이 묘사한 상황에서 합리적인 행위를 선택함에 있어 지배의 원리와 기대 효용 극대화의 원리의 적용의 결과가 충돌한다는 것으로 설명하고 있다. 슐레징거와 이병욱은 지배의 원리에 의한 선택이 합당함을 논증하고 있다. 그들의 논증은 원래의 뉴컴 상황과 변형된 뉴컴 상황의 유비에 근거하고 있다. 이 글에서는 그러한 유비가 성립하지 않거나 성립할 경우 뉴컴 문제를 해결하는 데 흡족하지 않음을 보이려 하고 있다. 그리고 뉴컴 상황에서 지배의 원리를 사용해야 하는 독자적인 이유를 제시하고 있다.
이종권,윤화경 한국산학기술학회 2004 한국산학기술학회논문지 Vol.5 No.4
100%천연향을 이용하여 제작, 개발된 해충기피제의 기피력을 테스트하였다. 해충기피제를 착용한 그룹과 착용하지 않은 그룹으로 구분하여 실험실에서 사육한 모기와 서해안에 위치한 몽산포 해수욕장, 동해안에 위치한 낙산 및 설악 해수욕장과 천안에 있는 태조산에서 해충에 대한 기피력을 측정하였으며, 각 그룹별로 5명씩 5회에 걸쳐 각 회당 1시간동안에 흡혈 개체로부터 물린 갯수를 확인하여 이들의 평균값을 계산하였다. 그 결과, 실험실에서는 91%, 몽산포 해수욕장에서는 78%, 낙산 및 설악 해수욕장에서는 93%, 태조산에서는 90%의 기피력을 보여주었으며. 이는 상당히 탁월한 기피효과를 나타내었다. The pulp fabric impregnanted 100% natural insect repellent was evaluated in an environmental chamber (laboratory, mongsanpoo beach, taejo Mt, naksan and seolak beach) for their repellent efficacy against insects. The results showed significant average repellency of 91 %, 78%, 90%, and 93% of laboratory, mongsanpoo beach, taejo Mt, naksan and seolak beach, respectively, during the 1hour of exposure period.