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신장질환과 동반된 고혈압 환자에서 Cicletanine HCl이 신기능에 미치는 영향에 관한 연구
이강욱,신영태 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2
Cicletanine HCl is the first delivative of the furopyridines, a new class of antihypertensive agents. The properties of cicletanin HCl involve increased prostacycline release, vascular H_1, H_3, receptor antagonism and modulation of intracytosolic free calcium. In order to evaluate the effect of cicletanine HC1 to renal function in hypertensive patients with renal disease, we examined twenty one patients with hypertension and renal disease in Chungnamnam National University Hospital, before and four weeks after administration of cicletanine HCl 100 mg per day . The results were as follows : 1. Mean age of patients was 50 years and man was 1.3 times more than woman. 2. Eight with hypertensive nephropathy, 7 with unknown cause chronic renal failure and 6 patients with diabetic nephropathy were included. 3. Systolic, diastolic and mean blood pressure of all patients decreased significantly, and 62 % of patients showed normalized blood pressure at end point of study 4. Parameters of renal function such as BUN, serum creatinine and creatinine clearence were not changed. 5. Amounts of 24 hour uninary protein excretion in patients goup with massive proteinuria ( >3.0 g/day,n = 13 ) decreased significantly, 4 weeks after cicletanine HCl administration. 6. Serum cholesterol, triglyceride, ALT, AST, uric acid, muscle enzyme and serum electrolytes shch as sodium, potassium, calcium and phosphorus remained unchanged. 7. There was no significant side effect during 4 weeks course of cicletanine HCI administration. With results above, we think that cicletanm HCl can be used safely in hypertensive patients with renal disease.
李康郁 건국대학교 1971 學術誌 Vol.12 No.1
Obervation were made on the semen value of clinicaly healthy korean native and darts bulls for the purpose of determination of mean semen value and its seasonal variations during one year period. The semen sampling were scheduled by random in four different seasons and the sample size were appointed from 150 samples korean native bulls and 213 dairy bulls. The range or mean values of the amount of ejaculation semen, color, smell, concentration, PH, number of sperms, and malformation rate were determined in this and their respective standard deviation of means, and seasonal variations were as follows ; 1.The amount of ejaculation in the korean native bulls showed a range of 3cc to 7.5cc and with a mean of 4.99±0.52cc. Dairy bulls showed a range of 3.9cc to 13cc with a mean of 7.18±0.36cc. Ejaculation amount on semen of korean native bulls is less than those of the dairy bulls. There was no significant difference amount of semen in different seasones, ages and months. 2.The semen concentration value of korean native bulls and dairy bulls showed a range of (-) to (□), were found to .be same value and with a mean of 1.49±0.02(+) and dairy bulls with a mean of 0.91±0.39(+). There was a highly concentration in the korean native bulls, (P <0. 01). There was a seasonal variation and ages difference which was not found to be not significant of the statistics. 3.The Semen of He Korean native bull who high in Concertation. (P) 6.2 to 6.6 that designated to be a same value. The PH value of semen from korean native bulls was less acid than those of dairy bulls with a mean of 6.25±0.02, dairy bulls with a mean of 6.37±0.06 (p<0.01) 4.The number of sperms korean native bulls showed a range of 75.5×104/cmm to 198.7×104/cmm with a mean of 115.8×104/cmm. Dairy bulls showed a range of 42.3×104/cam to 132.5×104/cmm with a mean of 68.96±4.60×104/cnlm. There was highly number of sperms korean native bulls than dairy bulls. 5.The motility of sperms of korean native bulls showed a range of 80% to 95% and with a mean of 94.12±0.19%. Dairy bulls showed a range of 75% to 95% with a mean of 93.12±2.31%. There was a active motillity of sperms in korean native bulls better than dairy bulls. 6.The Semen malformation rate of korean native bulls showed a range of 6.5% to 16.2%, with a mean of 10.54±0.39%. Dairy bulls showed a range of 1.7% to 8.1% with a mean of 4.94±0.42%. there was highly incidence of malformation rate in korean native bulls more than dairy bulls.
이강욱,최영환,신영태,노흥규,서광선 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1
Twenty eight cases of primary IgA nephropathy were diagnosed and studied in the Department of Internal Medicine, Chungnam National University Hospital over a period of 49 months from June 1981 to July 1985. The results were summerized as follows: 1. These cases represented 45.2% of patients with primary glomerular diseases undergoing renal biopsy and immunofluorescent studies during the same period. 2. There were 20 males and 8 females. They were 15 to 54 years old and the average age was 29.1. 3. The main symptoms were loin pain, gross hematuria, myalgia, fatigability and generalized edema in 18, 15, 12, 12, and 4 cases, respectively. Upper respiratory tract infection symptoms were presented in 50% of the cases of all patient just before and during the course of disease. 4. Proteinuria was observed in 27 cases and hematuria was seen in 23 cases, Among hematuria, the gross hematuria was observed in 15 cases. Hypoalbuminemia and hypercholesterolemia was presented in 4 cases with generalized edema. Serum BUN and creatinine were elevated in 3 cases with marked decreased Creatinine Clearence in 3 cases (Ccr<50ml/min). 5. The light microscopic findings showed mainly mesangial proliferative glomerulonephritis and focal and segmental glomerular sclerosis in 11 and 7 cases, respectively. Immunofluorescent microscopic findings disclosed diffuse mesangial deposit of IgA in all cases. IgG, igM, C3 and fibrinogen deposits were observed in mesangium in 5, 4, 20, and 7 cases, respectively.
패널데이터를 활용한 COVID-19 발병 전후의 사회적 고립감 비교
이강욱 한국상담심리교육복지학회 2023 상담심리교육복지 Vol.10 No.3
본 연구는 인구통계학적 특성에 따라 COVID-19 발병 전후 사회적 고립감이 어떻게 변화했는지살펴보고, 사회적 고립감을 완충하기 위한 개입방안 모색에 근거자료를 제공하고자 수행되었다. 이를 위해 한국행정연구원이 발표한 2019년과 2021년 패널데이터를 이용하여 SPSS 21.0 프로그램으로분석하였다. 2019년 데이터는 COVID-19 이전 상황을, 2021년 데이터는 COVID-19 이후 상황을 나타낸다. 연구결과 외로움을 느끼는 정도, 자살하고 싶은 생각이 드는 정도, 아무도 나를 잘 알지 못한다고 느끼는 정도와 같은 사회적 고립감은 COVID-19 발병 이후 전반적으로 증가하였으나 일용근로자의 경우에는 감소한 것으로 나타났다. 또한 성별, 연령, 교육 수준에 따라 분류된 그룹 간에도사회적 고립감의 차이가 관찰되었다. COVID-19 이후 집단 심리방역이 더욱 중요해짐에 따라 인구통계학적 특성 외에 사회적 고립감에 영향을 미칠 수 있는 다양한 요인에 대한 연구가 필요하다.