Erythromycin에 의한 Theophylline Clearance의 減少

柳東淑,申鉉澤,金有瑩 한국병원약사회 1990 병원약사회지 Vol.7 No.2

A latent effect of erythromycin on theophylline clearance has been demonstrated. Controlled studies involving normal subjects or patients with pulmonary disease have shown that a week or more course of erythromycin decreases theophylline clearance by 15% to 60% in western population. This case report of 49 year old Korean female shows significant reduction of theophylline clearance as much as 35.4% by concurrent administration of erythromycin.

농촌관광객의 농촌관광 행동의도에 관하여 TPB와 PA이론의 비교연구

유동숙(You, Dongsook),홍경완(Hong, Kyungwan) 대한관광경영학회 2018 觀光硏究 Vol.33 No.2

This study analyzed behavioral intention of rural tourists to predict the relationship between cognition-behavior and emotion-behavior of rural tourists by applying the theory of planned behavior and pleasure-arousal theory to know what attitude rural tourists form toward rural tourism activities and put into action. Analysis results are as follows. First, although attitude factor toward rural tourism which is a personal opinion out of explanatory variables of the theory of planned behavior that this study applied to analyze cognitive attitude of rural tourists did not exert a significant influence, subjective norm, an opinion of surrounding people and perceived behavior control factor which is a personal situation has a significant influence. Second, pleasure-arousal dimension that this study applied to analyze emotional attitude of rural tourists has a significant influence on the behavioral intention. Third, with respect to the explanation power of the two models, the model of the theory of planned behavior which is a cognitive attitude factor explains higher behavioral intention, and subjective norm which is an opinion or thought of surrounding people is reflected strongly for tourists who experienced rural tourism to participate in rural tourism. 본 연구는 농촌관광객이 농촌관광활동에 대한 어떤 태도를 형성하고 행동에 이르는지 계획행동이론과 즐거움-각성이론을 적용하여 농촌관광객의 인지-행동, 감정-행동의 관계를 예측하고자 농촌관광객의 행동의도를 분석하였다. 분석결과는 다음과 같다. 첫째, 농촌관광객의 인지적 태도를 분석하고자 적용한 계획행동이론의 설명변수 중 개인의 견해인 농촌관광에 대한 태도요인은 유의미한 영향을 미치지 않았으나, 주변인의 견해인 주관적 규범, 개인의 상황인 지각된 행동통제요인은 유의미한 영향을 미치는 것으로 나타났다. 둘째, 농촌관광객 의 감정적 태도를 분석하고자 적용한 즐거움-각성차원은 행동의도에 모두 유의미한 영향을 미치는 것으로 나타났다. 셋째, 두 모형의 설명력에서 인지적 태도요인인 계획행동이론의 모형이 더 높은 행동의도를 설명하는 것으로 나타났으며, 농촌관광을 경험한 관광객들은 농촌 관광을 참여하는데 주변인의 의견이나 생각인 주관적 규범이 가장 강하게 반영되는 것으로 나타났다.

대구시민의 농촌관광인식이 감정적 태도와 행동의도에 미치는 영향

유동숙(Dong Sook You),홍경완(Kyung Wan Hong) 한양대학교 관광연구소 2014 觀光硏究論叢 Vol.26 No.1

태도의 단일차원의 견해를 바탕으로 도시민이 농촌관광을 어떻게 인식하는지를 확인하고, 감정과 행동의도에 어떠한 영향을 미치는지 파악하는데 목적이 있다. 농촌관광인식의 요소는 교육적 인식, 경제적 인식, 문화적 인식, 환경적 인식의 4개 요인으로 확인하였으며, 교육적 인식 요인이 감정적 태도와 행동의도에 가장 높은 유의성을 나타내었다. 농촌관광의 감정적 태도는 농촌관광 행동의도에 유의한 영향을 미치는 것으로 나타났으며, 인식이 행동의도에 미치는 유의성보다 감정적 태도가 행동의도에 미치는 유의성이 더 높게 나타났다. 이는 인식보다 감정이 행동으로 연결될 영향성이 더 높다는 것을 나타낸다. 결론적으로 농촌관광 프로그램을 개발하거나 마케팅 전략을 수립할 때, 도시민의 수요와 인식에 기인하여야 한다는 것을 확인할 수 있었다. The objective is to check how urban residents recognize the rural tourism and to understand how they have the effect on the emotion and the behavior intention based on the view of single dimension of attitude. The factor of rural tourism recognition has been identified as 4 factors such as the educational recognition, the economical recognition, the cultural recognition and the environmental recognition, the factor of educational recognition showed the highest significance in the emotional attitude and the behavior intention. The emotional attitude of rural tourism appeared to have the significant effect on the behavior intention of rural tourism, the significance having the effect of emotional attitude on the behavior intention appeared higher than the significance having the effect of recognition on the behavior intention. This shows that the influence of emotion to be connected to the behavior is higher than the recognition. To conclude, when the program of rural tourism is developed or the marketing strategy is established, it could be identified that it should result from the demand and the recognition of urban residents.

韓國人의 Phenytoin 藥動學的 變數

柳東淑,申阮均,李明杰,李民和,李尙馥 한국병원약사회 1991 병원약사회지 Vol.8 No.4

Because of its narrow therapeutic range and capacity-limited metabolism, dosage adjustment of phenytoin in epileptic patients is difficult. Currently, Bayesian method which estimates the most probable parameters of Vmax and Km for each patient based on population parameters seemed to be very useful approch for adjusting phenytoin dosage. However, published population parameters of phenytoin are variable depend on authors. Therefore, this study was performed to estimate the values of Km and Vmax in Korean. Data from 20 adult neurologic outpatients in Seoul National University Hospital whose liver & renal function are normal were evaluated retrospectively. Two steady-state concentration data at two different doses were collected from each patient. In the present study, phenytoin pharmacokinetic parameters, Vmax & Km, were calculated from these two dose-concentration data by using Michaelis-Mented equation. Estimated mean value of Vmax and Km were 6.72㎎/㎏/day(SD 1.34:CV 20%) and 4.77㎍/㎖(SD 2.39:CV 50%). respectively. The coefficient of variations for each parameter show significant interindividual variation which is similar to other authors' results.

확장된 계획행동이론을 적용한 농촌관광의 행동의도 연구

유동숙(Dong-Sook You),홍경완(Kyung-Wan Hong) 한국관광연구학회 2017 관광연구저널 Vol.31 No.3

Clinical Pharmacokinetic Consultation Service

柳東淑 한국병원약사회 1990 병원약사회지 Vol.7 No.2

Therapeutic range가 좁고, 체내약물동태의 개체차가 심한 약물들은 상용량이나 경험적인 투약 방법으로는 적절한 유효혈중농도를 유지하기가 어렵다. 따라서 혈중약물농도를 측정하여 용량을 조절하고자 하는 시도가 이루어져 왔으나, 약물동태학적해석이 결여된 단순한 농도측정만으로는 측정농도를 실제 환자의 약물요법에 응용하는 비율이 극히 낮고, 때로는 오히려 환자치료에 해가 될수도 있다는 연구결과가 나왓다.

中国 中东部 农村住宅의 고령자의 거주에 관한 调查研究 - 安徽省 滁州市를 中心으로 -

유이연,이동숙,윤충열 한국농촌건축학회 2014 농촌건축 : 한국농촌건축학회논문집 Vol.16 No.2

Cities of China have been expanding rapidly during the last 10 years and the living environment of urban population developed highly making little difference with the developed nations. However, in the case of rural area, situation is totally different from the urban area. There are some cases where the quality of life in rural areas is retreating compared to the past. Agrarian cultures of the past are remained in the rural area with only older generations and no younger generations. The difference between the rural and the urban and the movement to the cities are increasing in a rapid speed. This led to the recognition of potential danger that lies on the agricultural societies which can demolish the economic development’s sustainability. Therefore, in this study, basic information about the current Chinese elderly’s house circumstances and to build new houses suited for the older generations will be provided. This can not only enhance the quality of the elder citizen’s life, but also can be a meaningful research for the ideal construction of future Chinese agriculture.

부부갈등과 분노의 관계에서 탈중심화의 조절효과 : APIM 모델 적용

장동숙,유금란 한국여성심리학회 2018 한국심리학회지 여성 Vol.23 No.2

The purpose of the study was to examine the role of decentering as a moderator in the relationship between marital conflict and anger by applying Actor-Partner Interdependence Model (APIM). A total of 291 married couples ranged from age 20s and 60s participated in the study and completed a questionnaire packet including variables related to martial conflict, anger, and decentering. The results indicated that there was a direct effect of the decentering on anger for both wife and husband but no parter effect. In addition, the decentering played as a moderator between marital conflict and anger for both husband and wife. For the partner effect, only wife’s decentering moderated on the relationship between husband’s marital conflict and wife’s anger. The implications and limitations for the study were discussed.

中国中东部农村住宅의 特徵에 관한 调查研究 : 安徽省 滁州市를 中心으로

유이연,이동숙,윤충열 한국농촌건축학회 2013 농촌건축 : 한국농촌건축학회논문집 Vol.15 No.1

韓國人의 Theophylline Clearance

金辰慶,柳東淑,申鉉澤,金洛斗,金辰圭,金建烈,金有瑩 한국병원약사회 1987 병원약사회지 Vol.4 No.1

Theophylline (1, 3-dimethyl xanthine) is commonly used in patients with acute and chronic reversible air way diseases. Because of its narrow therapeutic range and side effects related with toxic theophylline blood level, therapeutic drug monitoring is essential to maintain safe and effective dosing. Especially, the determination of initial dose is extremely important during the acute phase of asthmatic attacks. The maintenance dose of initial infusion can be calculated from each patient's clearance value. Population theophylline clearance value of Americans were reporter by Jusko. Up to now, no clinical data on pharmacokinetic parameters (clearance, volume of distribution, etc) based on Korean population are available. This fact makes it more difficult to keep patients in safe and effective therapeutic ranges of theophylline, when empirically dosed. Therefore, population theophylline clearance values of Koreans are vitally required for the safe dosing for asthma patients. This study was aimed to explore the theophylline clearance of Koreans by comparing with that of Americans reported by Jusko. As a result of this study, we could not deny the null hypothesis that theophylline clearance value of Americans is similar to that of Koreans. It is assumed that the clearance values of theophylline derived from Americans may by useful for dosage individualization of theophylline therapy in Korean asthma patients.