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내인성 N1- methylnicotinamide 를 이용한 신혈장유량측정
심창구 한국약제학회 1983 Journal of Pharmaceutical Investigation Vol.13 No.1
Renal plasma flow (RPF) was estimated from the extraction ratio (E.R.) and renal plasma clearance of the endogenous N¹-methylnicotinamide(NMN) in the experimental renal failure (ERF) rat, and was compared with that of healthy rats. PRE of ERF-rats was not different from that of the healthy rat significantly and dependened upon E. R, or intrinsic clearance of the kidney. This NMN method seemed to be superior to the conventional p-aminohippuric acid (PAH) method clinically.
상피세포 성장인자의 경피흡수 : 정상피부 , 각질제거피부 및 화상피부에 있어서
심창구,조애리,이정욱,안병락,정주영,고여욱 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.1
In vivo and in vitro skin permeation of recombinant ^(125)I-EGF through normal. stripped and the first degree burn skin were studied. The in vitro skin permeation rate through the first degree burn skin (296 cpm/㎠/hr) and the stripped skin (1131 cpm/㎠/hr) were 3.5 times and 13 times higher, respectively, as compared with the one through normal skin. In vivo absorption study with the first degree burn skin, the peak concentration of EGF in the skin was achieved at 1-3 hr and decreased afterward up to 8 hr with an elimination constant of 1.31 × 10³g/㎖/hr. To investigate the higher elimination rate of EGF in burn skin, binding and metabolism studies were conducted. No significant metabolism of EGF in burn skin (100℃, 5second burning) was observed. With the presence of unlabelled-EGF, ^(125)I-EGF permeation through the burn skin showed higher permeation rate than the one without unlabelled-EGF. The result may indicate that EGF-receptor binding play a role in determining the skin permeation rate.
경구투여된 약물의 혈장중 농도곡선에 나타나는 다중피크 현상의 해석
심창구,이혜원 한국약제학회 1991 Journal of Pharmaceutical Investigation Vol.21 No.4
There are many drugs reproted to show unusual pharmacokinetic behavior by producing a significant secondary peak in the plasma concentration-time curve after oral administration. The drugs are ranitidine. cimetidine, acetaminophen, aspirin, furosemide, bumetanide, piretanide, veralipride, sobrerol, penicillamine and doxycycline etc. Enterohepatic circulation-, two absorption site-, biphasic gastric emptying-, tissue deposition- and multi-fraction absorption theories have been suggested for the mechanisms of this phenomenon. Here, the theories were reviewed and critisized for their validity as a possible mechanism of the multiple peak phenomenon.
음이온 모델 화합물 아마란스의 담즙배설에 미치는 타우로데옥시콜레이트의 영향
심창구,정석재 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.3
Plasma disappearance of amaranth (AM), a model compound of organic anionic drugs, was retarded by intravenous infusion of taurodeoxycholate (TDC), a representative bile acid, in the rat. Biliary excretion accounted for 30-60% of the systemic excretion of AM. AM seemed to be metabolised in the hepatocyte to form a compound that is excreted more rapidly into the bile than AM itself, considering apparent biliary clearance, CL_(bil), is much larger than systemic clearance, CLs. Decrease in CL_(bil) by TDC infusion might be due to elevated plasma level rather than decreased biliary excretion of AM. Decreased distribution or urinary excretion of AM by TDC was supposed to be one of the probable reasons of elevated plasma level. Competitive inhibition between AM and TDC on tissue distribution and urinary excretion might explain the mechanism. The effect of TDC on the CL_(bil) of methylene blue, a cationic dye, was quite different from that of AM, as reported previously by us. More intensive study would be necessary to elucidate the difference of biliary excretion between organic anions and cations.
앰플 및 1회용 주사용기에서의 미립자 혼입에 관한 비교연구
심창구,한용해,권돈선 한국약제학회 1991 Journal of Pharmaceutical Investigation Vol.21 No.3
Particulate is the foreign insoluble material in injectable solution inadvertently present in a given product. Considerable efforts have been made to avoid or minimize particulate contamination by pharmaceutical manufacturers during the production of parenteral products. Particulate contamination of the parenteral products can occur mainly during the opening (cutting) the container immediately before clinical use. In this study, particulate contamination generated during the opening process of ampoules (conventional type, 1-point and color-break ampoules) was compared with that of a prefilled injectable container (prefllled syringe). The particles were examined under a microscope after filtration of the total fluids in the containers. Particles having wide range of size distribution were found from all the ampoules tested. The contamination from the 1-point ampoule and color-break ampoule was much less than from the conventional ampoule. Glass particles generated by cutting the glass-made ampoules seemed a principal source of the particulate contamination. The glass-partiaulte contamination could be improved substantially by replacing the ampoule containers with the prefilled syringe. Prefilled syringe, which can be used without any cutting process, did not generate particulates during the use. Therefore, it was concluded that prefilled syringe is most preferable container for the small volume parenteral (SVP) fluids in terms of particulate contamination.