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증예(症例) : Hemoclip요법으로 치료한 직장 Dieulafoy 병변 1예
이기훈 ( Ki Hoon Lee ),고강훈 ( Kang Hun Koh ),박승용 ( Seung Yong Park ),오호준 ( Ho Jun Oh ),황정환 ( Heong Hwan Hwang ),이태환 ( Tae Hwan Lee ),김상욱 ( Sang Wook Kim ),이승옥 ( Seung Ok Lee ),이수택 ( Soo Teik Lee ) 전북대학교 의과학연구소 2005 全北醫大論文集 Vol.29 No.1
직장의 Dieulafoy 병변은 하부 위장관 출혈의 매우 드문 원인이다. 최근 대장내시경의 발달로 진단과 치료가 용이하여 성공적인 지혈이 가능하게 되었다. 내시경적인 치료 방법에는 전기응고, hemoclip요법, 에피네프린과 경화제 주입, 밴드 결찰술 등이 있으며 상부위장에서의 지혈술과 크게 다르지 않다. 저자들은 68세 남자에서 직장의 Dieulafoy 병변으로 인한 대량 출혈을 내시경으로 진단하고 hemoclip요법으로 성공적으로 치료하여 문헌고찰과 함께 보고하는 바이다. Dieulafoy`s lesion is an uncommon cause of gastrointestinal bleeding that occurs after rupture of an exposed submucosal artery. The majority of lesions are found in the stomach, but less commonly similar lesions have also been identified in the duodenum, jejunum, colon, and in rare cases, the rectum. A 68-year-old man with chronic renal failure who presented with massive hematochezia was subsequently found to have a Dieulafoy lesion in the rectum. The bleeding was successfully managed by endoscopic hemoclipping. We report a case of rectal Dieulafoy lesion in which bleeding was comtrolled by endoscopic hemoclipping.
정치량 ( Chi Ryang Chung ),홍윤경 ( Yun Kyung Hong ),김소영 ( So Young Kim ),최영훈 ( Yung Hun Choi ),나영균 ( Young Gyun Na ),박승용 ( Seung Yong Park ),황정환 ( Heong Hwan Hwang ),문희 ( Hee Moon ),오호준 ( Ho Jun Oh ),이석 ( 전북대학교 의과학연구소 2005 全北醫大論文集 Vol.29 No.2
Background: An alteration in the balance between a T-helper type 2 cell (Th2) response and a T-helper type 1 cell (Th1) response may predispose to the development of bronchial asthma. IL-18 has an ability to promote both Th1 and Th2 responses depending on the surrounding cytokine environment. Reactive oxygen species (ROS) play a crucial role in the pathogenesis of airway inflammation and hyperresponsiveness. Objective: An aim of the present study was to determine the effect of ROS on the regulation of IL-18 expression. Methods: We used a C57BL/6 mouse model of allergic asthma to examine effects of antioxidants on the regulation of IL-18 expression. Our present study with ovalbumin (OVA)- induced murine model of asthma revealed that ROS production in cells from bronchoalveolar lavage (BAL) fluids was increased, and that administration of L-2-oxothiazolidine-4-carboxylic acid (OTC) or α-lipoic acid reduced the increased levels of ROS, the increased expression of IL-18 protein and mRNA, airway inflammation, and bronchial hyperresponsiveness. Our results also showed that antioxidants down-regulated a transcription factor, nuclear factor-kB (NF-kB) activity. Conclusion: These results indicate that antioxidants may inhibit LL-18 expression in asthma by inhibiting activity of NF-kB, and suggest that ROS regulate the LL-18 expression.