Chinese Hamster Ovary $K_1$ 세포의 자매염색분체교환에 미치는 카드뮴의 영향에 관한 연구

황인경,김돈균,Hwang, In-Kyung,Kim, Don-Kyoun 대한예방의학회 1990 Journal of Preventive Medicine and Public Health Vol.23 No.2

In order to examine the mutagenicity of cadmium dichloride the author studied the induction of sister chromatid exchanges in chinese hamster ovary $K_1$ cells which treated with cadmium dichloride at various concentrations. The results obtained were as follows : 1. In cells treated with $10^{-4}M$ cadmium dichloride, a small number of cells were viable but no mitosis was bound. 2. The frequencies of sister chromatid exchanges in cells treated with $10^{-5}M\;and\;10^{-6}M$ cadmium dichloride as $10.7{\pm}1.9\;and\;8.3{\pm}2.1$, respectively, were significantly increased for control ($6.0{\pm}2.3$). (P<0.05). 3. There were dose-dependent relationship between the concentration of cadmium dichloride and frequency of sister chromatid exchanges in cells treated with cadmium dichloride at concentration ranging from $10^{-5}\;to\;10^{-7}M$.

셰익스피어 주요 회극에 나타난 기독교적인 화해

황인경 ( In Kyung Hwang ) 한국기독교어문학회 2010 기독교와 어문학 Vol.7 No.1

To solve the problem of the divisions and fractions in the society, Shakespeare might think that it should be necessary to contain biblical allusion in his comedies. To harmonize and compromise one another, he might give his readers a deep impression, as All scripture is God breathed and is useful for teaching, rebuking, correcting and trifling in righteousness. (2 Timothy 3:17) Those days when Shakespeare lived in Europe, it began to be confronted with the chaos including the religion, the battle lines leading the English Civil War. Pervading the works of Luther and Calvin, Renaissance Humanism was not just only for a human, and not for the egoistics those days, The ideology of it included that the human rights are gifted by God, The humans of their feelings and emotions would be very precious, so that they might want it to be recognized and appreciately earnestly by God, Those whore in favor of it would try to desire and appeal their free-will to God. Each personality should be high and noble, however, it was invaded by Roman Catholic bureaucracy, The Elizabeth Religious settlement was Elizabeth l`s response to the religious divisions created from the reign of Henry VIII to that of Mary I in Scotland, This response, described as The Revolution of 1559, was set out in two Acts of the parliament of England. The Act of Supremacy of 1559 re-established the Church of England`s independence from Rome, with Parliament conferring on Elizabeth the title Supreme Governor of the church of England, while the Act of Uniformity of 1559 set out from the English church would now take, including the establishment of the Book of Common Prayer. When Mary died in 1558, Elizabeth succeeded to the throne. One of the most important concerns during Elizabeth`s early reign was the question of which form the state religion would take. Communion with the Roman Catholic Church had been restored under Mary using the instrument of Royal Supremacy, according to the English formal history. Shakespeare had the Elizabethan compromise; as our summarizing Elizabethan period, consensus to come on these and other theological issues that consumed the 16th century equivalent of the blogs of Elizabethan day there would have been no church of England and no Anglican Communion to be arguing about these many centuries later. Thirteen and fifteen year olds are not` adopting a lifestyle, they`re trying to figure out who they are, who God created them to be and what on earth to do with this confusing bunch of sexual feelings that they`re trying to get a handle on. Although there were religious war against Scotland, England would adopt King James Version translated by James I as one bible. In Shakespeare`s, it was necessary to harmonize and reconcile the conflicts in England. He would persuade them to reunion the divided Kingdoms by his major comedies with his lampoon. His conversations in them might have an indirect expression to teach it to those who would cause the contradictions and divisions to deprive the King`s throne unfairly in As you like it, the hidden religious stmggles with lover`s marriage in A Midsummer Nighfc Dream and getting sue about the logical law, without love, made by the egoistic humans in The Merchant of Venice. He would like to show the characters created by him, respectively need role models for healthy relationships between absolute being and human beings to appeal to his readers, in the name of our Lord Jesus Christ, that all of you agree with one another so that there may be no divisions among you and that you may be perfectly united in mind and thought, with secrete or euphemism to have a unification from their confliction those days.

방사선취급 병원근무자들의 염색체이상 및 자매염색분체교환 빈도

차애리,김미선,황인경,이수일,조병만,김돈균,Cha, Ae-Ri,Kim, Mi-Sun,Hwang, In-Kyung,Lee, Su-Ill,Cho, Byung-Mann,Kim, Don-Kyoun 대한예방의학회 1998 예방의학회지 Vol.31 No.4

In order to evaluate the cytogenetic hazard among hospital workers potentially exposed to low dose of radiation, the analysis of chromosome aberrations(CA) and sister chromatid exchanges(SCE) in lymphocytes were performed in 79 hospital workers and 79 non-exposed workers. The mean frequency of chromosomal exchange and deletion(respectively, $0.20\times10^{-2}/cell\;and\;0.39\times10^{-2}/cell$) in the exposed group were significantly higher than those$(0.07\times10^{-2}/cell\;and\;0.23\times10^{-2}/cell)$ in control group. The frequency of sister chromatid exchanges was 5.04/cell in the control vs. 6.57/cell in the exposed group. There were also significant differences in the mean frequencies of CA and SCE adjusted for age, sex, smoking, drinking between two groups. There were no evidence of significant increase of CA and SCE according to the department or duration of employment. But the frequency of cells having chromosome aberration was significantly higher in the exposed group than in the control group related to duration of employment. There was no dose-effect relationship between the cumulative doses and the frequency of CA and SCE. But in the case of last 1 yr cumulative dose, there were evidence of significant dose-dependant increase of chromosome type CA and percentage of cells with aberration. The result suggest that there is cytogenetic hazard in risk group like hospital workers handling low dose radiation. And the analysis CA and SCE are useful biological indicators for the exposure of low dose level of radiation.

균형성과표를 이용한 응급의료센터 핵심성과지표 개발

권영달 ( Young Dal Kwon ),황인경 ( In Kyung Hwang ),이재희 ( Jae Hee Lee ),서원식 ( Won Sik Suh ) 한국보건경제정책학회 2010 보건경제와 정책연구 Vol.16 No.3

A research in evaluating performance of emergency medical center with application of Balanced Score Card (BSC) is in the beginning stage. The purpose of this study is to develop Key Performance Indicators (KPI) for emergency medical centers adopting BSC. Through literature review and brown-bag meetings with staffs at K hospital, the study refined 30 KPIs for emergency medical center. The study confirmed the validity of KPIs by analyzing 232 copies of questionnaires collected for the analysis. Based on the analysis, 26 KPIs has been finally chosen, 5 KPIs in financial, 7 KPIs in customers, 8 KPIs in learning & growth, and 6 KPIs in internal business processes perspective. Also, the study showed KPIs with higher weights in each dimension of BSC. Finally, the study tested a statistical significance of hypothesized relationship through an structural equations model by utilizing the statistical package of AMOS 7.0. 13 among 22 hypothesized relationship were accepted. The study proposes an effective performance indicators for professionals at emergency medical centers and it is expected to be likely to have positive influence upon enhancing services of the center.

복합만성질환의 흔한 유형과 의료비에 미치는 영향

김창훈 ( Chang Hoon Kim ),황인경 ( In Kyung Hwang ),유원섭 ( Weon Seob Yoo ) 한국보건행정학회 2014 보건행정학회지 Vol.24 No.3

Background: Current trends in Korea population aging with advances in public health and clinical medicine foretell rises in the prevalence of not only chronic diseases but also patients with multimorbidity. One important aspect in analyzing multimorbidity is to define the list of chronic diseases included when calculating multimorbidity index. The objective of this study is to describing the effect of multimorbidity on healthcare cost in Korea using US Office of the Assistant Secretary of Health (OASH) list. Methods: We analyzed the Korea Health Panel Data representing non-institutionalized Korean adult populations aged 20 and more. We calculated multimorbidity index based on OASH list and estimated the prevalence and healthcare cost for each OASH chronic disease. Results: In 2011, 15.2 million (39.6%) Koreans aged 20 and more were living with chronic condition. The health care cost due to chronic diseases, accounted for 80.2% of the overall healthcare costs and the prevalence of chronic conditions, the prevalence of multimorbidity and healthcare cost increased with ages. In the analysis using OASH list, 40% of the adult population over the age of 20 and 66.7% of the population over the age of 65 was affected with multimorbidity. In most of diseases in OASH list, prevalence of mulitmorbidity was high and healthcare cost increased with multimorbidity. Conclusion: OASH chronic disease list that accounts for 72.4% of prevalence and 86.7% of healthcare cost of persons with chronic conditions in Korea. OASH chronic disease list would be a useful and representative indicator for studying multimorbidity.

국민건강보험 지역가입자 중 뇌졸중 입원환자의 의료이용 양상 및 지역친화도 추이 (1998-2005)

김지현 ( Ji Hyun Kim ),조병만 ( Byung Mann Cho ),황인경 ( In Kyung Hwang ),손민정 ( Min Jeong Son ),윤태호 ( Tae Ho Yoon ) 한국보건행정학회 2008 보건행정학회지 Vol.18 No.4

Objectives: This study aimed to offer some fundamental evidences for the stroke management policy by investigating the trends of medical care utilization and regionalization in stroke inpatients. Methods: We used the National Health Insurance claims and registry data for stroke inpatients from 1998 to 2005. Among all stroke inpatient claims data, self-employed insured and their dependents were only included in this study. The classification of stroke was based on ICD-10(I60-I69) and its subtype was divided by hemorrhage(I60-I62) and infarction(I63-I64) type. To evaluate regionalization of medical care utilization, relevance index was calculated by regions. The regions were classified 8 large catchment areas and 163 self authorized areas. Results: The overall medical care utilization rate of stroke inpatient has been increased, especially infarction subtype. Among medical care institutions, the utilization of hospital has been the most rapidly increased. Although considered annual rate of interest, total medical cost of stroke inpatients has been increased, Totally, more than 84% of stroke inpatient were admitted to medical care institutions in their own large catchment area during 1998-2005. The relevance indices in their own large catchment area(self efficiency rate) were more than 70% in most areas regardless of stroke subtype except Chungbuk catchment area. Self sufficiency rates of stroke inpatients among 163 areas in 1998 and 2005 were 84.2% and 83.1% in metropolitan, 46.7% and 45.5% in urban, and 19.5% and 22.6% in rural areas, respectively. Conclusion: Stroke management policy for improvement of distribution at the district level, especially in rural areas, may be helpful for reducing regional inequality in stroke.

Zinc와 Arachidonic Acid가 고 Fructose 식이로 유도된 인슐린 저항성에 미치는 영향

최철수(Chul-Soo Choi),김영욱(Young-Wook Kim),이효선(Hyo-Sun Lee),윤태호(Tae-Ho Yoon),조병만(Byung-Mann Cho),이수일(Soo-Il Lee),김성수(Sung-Soo Kim),황인경(In-Kyung Hwang) 한국식품영양과학회 2009 한국식품영양과학회지 Vol.38 No.4

고 fructose 식이를 섭취시켜 제 2형 당뇨를 유발한 쥐에서 ZA의 섭취가 혈당 조절에 미치는 기전을 밝히고자 하였다. 4주 동안의 실험기간 중 Control군(normal chow diet), Fructose군(high-fructose diet)과 Fructose+ZA군(highfructose diet+ZA treatment) 간의 체중, 먹이 및 물의 섭취량에는 유의한 차이를 나타내지 않았다(p<0.05). 기저상태(basal state)에서 혈장 포도당, 인슐린 농도 및 간의 포도당 생성률을 측정한 결과 Control군과 Fructose군 및 Fructose +ZA군 간의 차이를 나타내지 않았다. 인슐린 감수성을 알아보기 위한 hyperinsulinemic euglycemic clamp 실험에서 인슐린 농도와 포도당 농도는 군 간의 차이를 나타내지 않았다. 또한 인슐린 감수성 지표인 포도당 흡수(glucose uptake)에서도 역시 군 간의 차이를 발견하지 못하였다. 그러나 간의 인슐린 감수성 지표인 간의 포도당 생성률(HGO)에서는 Fructose군이 Control군에 비하여 유의적으로 증가되었고(p<0.05), Fructose+ZA군이 대조군의 수준으로 감소되었다. 이것으로 미루어 볼 때 fructose 식이는 간에서 인슐린 감수성을 감소시켰으나 당뇨는 유발되지 않았으며, ZA 섭취가 간의 포도당 생성률을 억제하는 것으로 보아 인슐린 감수성을 증가시키지만, 말초조직의 포도당 이용에는 영향을 미치지 않는 것으로 사료된다. We previously demonstrated that zinc plus arachidonic acid (ZA) treatment lowered blood glucose levels in streptozotocin-induced diabetic rats, genetically diabetic obese (ob/ob) mice, and genetically diabetic, non-obese Goto-Kakizaki rats. However, plasma insulin levels did not increase with ZA treatment, suggesting that ZA lowers blood glucose levels not by stimulating pancreatic insulin secretion. However, it is unclear whether these agents lower blood glucose levels by decreasing hepatic glucose output (HGO) or by increasing glucose utilization in peripheral tissues, or both. In order to determine ZA target organ of insulin action, we divided 18 Sprague-Dawley rats weighing ~130 g into 3 groups (6 rats per group) and treated them for four weeks with: (1) Control diet (regular rat chow), (2) High fructose (60.0%) diet only, and (3) the same fructose diet plus zinc (10 ㎎/ℓ) and arachidonic acid (50 ㎎/ℓ) containing drinking water. After 4 weeks, insulin action was assessed using the hyperinsulinemic euglycemic clamp technique. Food intake and body weights were comparable in all three groups of rats throughout the study period. Plasma glucose and insulin concentrations, glucose uptake, and HGO in the basal state were all the same in these three rat groups. During the clamp study, fructose-treated and fructose+ZA treated rat groups did not exhibit any detectable change on insulin-mediated glucose uptake compared to controls. High fructose feeding impaired insulin mediated suppression of HGO, compared to controls during clamp (4.39 vs. 2.35 ㎎/㎏/min; p<0.05). However, ZA treatment in high fructose-fed rats showed a remarkable increase in hepatic insulin sensitivity compared to high fructose-fed rats, reflected by a complete recovery in suppression of HGO during the clamp (4.39 vs. 2.18 ㎎/㎏/min; p<0.05). This data suggests that ZA increases insulin sensitivity in liver but not glucose utilization of peripheral tissues in high fructose-fed rats.

Teacher’s Paradigm: Teaching listening and speaking with Disney Fairy Tales:Frozen for TEYL

황인경 ( In-kyung Hwang ) 현대영미어문학회 2018 현대영미어문학회 추계학술대회 발표논문집 Vol.2018 No.-

부비동염이후 발생한 경막하 농양 1례

변정희,황인경,박은경,강주완,김동수,장광천,Byun, Jung Hee,Hwang, In Kyung,Park, Eun Kyung,Kang, Ju Wan,Kim, Dong Soo,Jang, Gwang Cheon 대한소아감염학회 2014 Pediatric Infection and Vaccine Vol.21 No.1

부비동염은 흔하고 일반적으로 소아에서는 양성질환인 경우가 많다. 경험적으로 사용하고 있는 항생제로 인해 소아의 부비동염의 두 개강 내 합병증은 드물지만, 발생할 경우 생명에 위협적일 수 있다. 두 개강 내 합병증은 정맥동 혈전, 안와 합병증, 뇌수막염, 뇌수막하 농양 등이 있다. 이러한 합병증은 소아에서 심각한 예후를 보일 수 있다. 따라서 뇌수막하 농양을 초기에 정확하게 진단하여 치료를 시작하는 것이 중요하다. 저자들은, 급성 부비동염 치료 중이던 15세 남아가 3일간의 발열, 두통을 동반한 편마비 증상으로 내원하여 뇌 전산화 단층촬영에서 뇌수막하 농양으로 진단되어 항생제 투여 및 신경학적 수술로 치료된 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. The current paper reports on a case of subdural empyema secondary to frontal sinusitis in an otherwise healthy child. Sinusitis is a common and benign condition in most pediatric cases. Because of the widespread use of antibiotics, intracranial extension of pediatric sinusitis is rarely seen today; however, complications (e.g., cavernous sinus thrombosis, orbital infection, meningitis, and subdural empyema) are potentially life threatening. A 15-year-old right-handed male presented with a 3-day history of fever, headache, and left-sided palsy. Computed tomography revealed right-sided subdural empyema with right frontal sinusitis and maxillary sinusitis. A postoperative inpatient neurological consultation was requested 2 months post-surgery due to motor function deficits. The results suggested that early and accurate diagnosis of subdural empyema leads to prompt treatment and a favorable outcome for the patient.

연구논문 : 야콘의 항산화성 및 야콘 초절임제품의 저장 중 품질특성

문보경 ( Bo Kyung Moon ),강희진 ( Hee Jin Kang ),황인경 ( In Kyung Hwang ),유경미 ( Kyung Mi Yoo ),문미정 ( Mi Jung Moon ) 한국식품조리과학회 2010 한국식품조리과학회지 Vol.26 No.3